GPR61

GPR61
Identifiers
Aliases	GPR61 , BALGR, GPCR3, G protein-coupled receptor 61
External IDs	OMIM: 606916; MGI: 2441719; HomoloGene: 12910; GeneCards: GPR61; OMA:GPR61 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.3 Start 109,539,872 bp [1] End 109,548,406 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.3 Start 108,055,637 bp [2] End 108,062,198 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex right frontal lobe Brodmann area 9 testicle anterior pituitary right hemisphere of cerebellum cingulate gyrus anterior cingulate cortex hypothalamus nucleus accumbens Top expressed in medial dorsal nucleus medial geniculate nucleus ventromedial nucleus piriform cortex inferior colliculi lateral geniculate nucleus central gray substance of midbrain anterior amygdaloid area paraventricular nucleus of hypothalamus medial vestibular nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding arrestin family protein binding Cellular component integral component of membrane receptor complex membrane plasma membrane endosome endosome membrane Biological process signal transduction G protein-coupled receptor signaling pathway positive regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83873 229714 Ensembl ENSG00000156097 ENSMUSG00000046793 UniProt Q9BZJ8 Q8C010 RefSeq (mRNA) NM_031936 NM_001393907 NM_175470 NM_001305461 RefSeq (protein) NP_114142 NP_001292390 Location (UCSC) Chr 1: 109.54 – 109.55 Mb Chr 3: 108.06 – 108.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene. ^{[5] [6] [7]}

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000156097 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046793 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID   11165367.
6. Cikos S, Gregor P, Koppel J (Nov 2001). "Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain". Biochim Biophys Acta. 1521 (1–3): 66–72. doi:10.1016/s0167-4781(01)00289-5. PMID   11690637.
7. "Entrez Gene: GPR61 G protein-coupled receptor 61".

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Conner AC, Hay DL, Simms J, et al. (2005). "A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors". Mol. Pharmacol. 67 (1): 20–31. doi:10.1124/mol.67.1.20. PMID   15615699. S2CID   22535315.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi: 10.1016/S0014-5793(02)02775-8 . PMID   12044878. S2CID   7116392.

See also

• GPR61+receptor,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.