GPR62

GPR62
Identifiers
Aliases	GPR62 , GPCR8, KPG_005, G protein-coupled receptor 62
External IDs	OMIM: 606917 MGI: 3525078 HomoloGene: 50962 GeneCards: GPR62
Gene location (Human)
Chr.	Chromosome 3 (human)
End	51,957,499 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	106,343,137 bp
RNA expression pattern
	Top expressed in
	inferior ganglion of vagus nerve; ; internal globus pallidus; ; subthalamic nucleus; ; endothelial cell; ; ventral tegmental area; ; corpus callosum; ; substantia nigra; ; external globus pallidus; ; medulla oblongata; ; putamen;
	Top expressed in
	seminiferous tubule; ; substantia nigra; ; anterior horn of spinal cord; ; suprachiasmatic nucleus; ; pontine nuclei; ; lateral geniculate nucleus; ; spermatocyte; ; ventral tegmental area; ; spermatid; ; dorsal tegmental nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity ; signal transducer activity ; protein binding ; identical protein binding ; arrestin family protein binding ;
Cellular component	integral component of membrane ; receptor complex ; membrane ; plasma membrane ; endosome ; endosome membrane ;
Biological process	signal transduction ; G protein-coupled receptor signaling pathway ; positive regulation of cAMP-mediated signaling ; inositol phosphate-mediated signaling ;
	Sources:Amigo / QuickGO
Orthologs
	118442
	436090
	ENSG00000180929
	ENSMUSG00000091735
	Q9BZJ7
	Q80UC6
	NM_080865
	NM_001159652
	NP_543141
	NP_001153124
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 17, 2023

Probable G-protein coupled receptor 62 is a protein that in humans is encoded by the GPR62 gene.^[5]^[6]

G protein–coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]^[6]

Related Research Articles

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.

Probable G-protein coupled receptor 160 is a protein that in humans is encoded by the GPR160 gene.

Probable G-protein coupled receptor 82 is a protein that in humans is encoded by the GPR82 gene.

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.

Probable G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene. It has been identified as a possible receptor for C-peptide.

Mas-related G-protein coupled receptor member D is a protein that in humans is encoded by the MRGPRD gene.

GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.

GPR156, is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily. By sequence homology, this gene was proposed as being a possible GABA_B receptor subunit, however when expressed in cells alone or with other GABA_B subunits, no response to GABA_B ligands could be detected. Therefore, the function of this protein remains to be elucidated. In vitro studies on GPR156 constitutive activity revealed a high level of basal activation and coupling with members of the Gi/Go heterotrimeric G protein family.

Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.

Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 150 is a protein that in humans is encoded by the GPR150 gene.

Probable G-protein coupled receptor 141 is a protein that in humans is encoded by the GPR141 gene.

Probable G-protein coupled receptor 153 is a protein that in humans is encoded by the GPR153 gene.

Probable G-protein coupled receptor 152 is a protein that in humans is encoded by the GPR152 gene.

G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene.

G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene. Recent research ('21) has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone; as well, the recently developed, potent, and GPR139 receptor selective agonist TAK-041 is currently undergoing trials to gauge the efficacy for treating psychiatric conditions such as major depressive disorder and the negative symptoms of schizophrenia.

Probable G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene.

Probable G-protein coupled receptor 61 is a protein that in humans is encoded by the GPR61 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180929 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000091735 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (Feb 2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res Mol Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
1 2 "Entrez Gene: GPR62 G protein-coupled receptor 62".

GPR62

Related Research Articles

References

Further reading