GPR25

GPR25
Identifiers
Aliases	GPR25 , G protein-coupled receptor 25
External IDs	OMIM: 602174; MGI: 2686146; HomoloGene: 3872; GeneCards: GPR25; OMA:GPR25 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 200,872,981 bp [1] End 200,874,178 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 136,187,535 bp [2] End 136,188,611 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad granulocyte blood appendix right uterine tube body of stomach spleen fundus upper lobe of left lung face Top expressed in prefrontal cortex nucleus accumbens visual cortex subiculum hippocampus proper primary visual cortex temporal lobe piriform cortex cerebellum stria vascularis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity protein binding signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2848 383563 Ensembl ENSG00000170128 ENSMUSG00000052759 UniProt O00155 P0C5I1 RefSeq (mRNA) NM_005298 NM_001101516 RefSeq (protein) NP_005289 NP_001094986 Location (UCSC) Chr 1: 200.87 – 200.87 Mb Chr 1: 136.19 – 136.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 25 is a protein that in humans is encoded by the GPR25 gene. ^{[5] [6]}

Structure

It is a member of the G protein-coupled receptor (GPCR) family and it's well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family. ^[7]

Tissue distribution

GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells. ^[7]

Function

See also: chemokine receptor and CXC chemokine receptor

It has been identified as the receptor for the chemokine-like protein CXCL17. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000170128 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000052759 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jung BP, Nguyen T, Kolakowski LF Jr, Lynch KR, Heng HH, George SR, et al. (Feb 1997). "Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1". Biochemical and Biophysical Research Communications. 230 (1): 69–72. doi:10.1006/bbrc.1996.5828. PMID   9020062.
6. "Entrez Gene: GPR25 G protein-coupled receptor 25".
7. Ocón B, Xiang M, Bi Y, Tan S, Brulois K, Ayesha A, et al. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. Bibcode:2024Natur.635..736O. doi:10.1038/s41586-024-08043-2. PMC   11887596 . PMID   39293486.

Further reading

• Sherva R, Miller MB, Lynch AI, Devereux RB, Rao DC, Oberman A, et al. (Apr 2007). "A whole genome scan for pulse pressure/stroke volume ratio in African Americans: the HyperGEN study". American Journal of Hypertension. 20 (4): 398–402. doi:10.1016/j.amjhyper.2006.10.001. PMC   1997287 . PMID   17386346.