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Patrick Baeuerle is a German-based molecular biologist, immunologist, professor and a biopharmaceutical entrepreneur. Baeuerle is known for his work on tyrosine sulfation of proteins, transcription factor NF-kappaB, and the development of bispecific T-cell engaging antibodies for therapy of cancer.
In molecular biology, the calcium-binding EGF domain is an EGF-like domain of about forty amino-acid residues found in epidermal growth factor (EGF). This domain is present in a large number of membrane-bound and extracellular, mostly animal, proteins. Many of these proteins require calcium for their biological function and a calcium-binding site has been found at the N-terminus of some EGF-like domains. Calcium-binding may be crucial for numerous protein-protein interactions.
Tyrosine-protein kinase CSK also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This enzyme phosphorylates tyrosine residues located in the C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1.
References
- ↑ Bettelheim, F. R. (1954). "Tyrosine-O-Sulfate in a Peptide from Fibrinogen". Journal of the American Chemical Society. 76 (10): 2838–2839. doi:10.1021/ja01639a073. ISSN 0002-7863.
- ↑ Mehta, AY; Heimburg-Molinaro, J; Cummings, RD; Goth, CK (June 2020). "Emerging patterns of tyrosine sulfation and O-glycosylation cross-talk and co-localization". Current Opinion in Structural Biology. 62: 102–111. doi:10.1016/j.sbi.2019.12.002. PMC 7308222 . PMID 31927217.
- ↑ (PROSITE pattern: PS00003)
- ↑ Monigatti, Flavio; Gasteiger, Elisabeth; Bairoch, Amos; Jung, Eva (2002-05-01). "The Sulfinator: predicting tyrosine sulfation sites in protein sequences". Bioinformatics. 18 (5): 769–770. doi:10.1093/bioinformatics/18.5.769. ISSN 1367-4811. PMID 12050077.
- ↑ "Expasy: The Sulfinator - documentation".
- ↑ Leyte, A.; Schijndel, H. B. van; Niehrs, C.; Huttner, W. B.; Verbeet, M. P.; Mertens, K.; Mourik, J. A. van (1991-01-15). "Sulfation of Tyr1680 of human blood coagulation factor VIII is essential for the interaction of factor VIII with von Willebrand factor". Journal of Biological Chemistry. 266 (2): 740–746. doi: 10.1016/S0021-9258(17)35234-1 . ISSN 0021-9258. PMID 1898735.
- ↑ Sako, Dianne; Comess, Kenneth M.; Barone, Karen M.; Camphausen, Raymond T.; Cumming, Dale A.; Shaw, Gray D. (1995). "A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding". Cell. Elsevier BV. 83 (2): 323–331. doi:10.1016/0092-8674(95)90173-6. ISSN 0092-8674. PMID 7585949.
- ↑ Johnston, Robert J.; et al. (2019-10-23). "VISTA is an acidic pH-selective ligand for PSGL-1". Nature. Springer Science and Business Media LLC. 574 (7779): 565–570. Bibcode:2019Natur.574..565J. doi:10.1038/s41586-019-1674-5. ISSN 0028-0836. PMID 31645726. S2CID 204849372.
- Moore KL (2003). "The biology and enzymology of protein tyrosine O-sulfation". J. Biol. Chem. 278 (27): 24243–6. doi: 10.1074/jbc.R300008200 . PMID 12730193.
- Hoffhines AJ; Damoc, E; Bridges, KG; Leary, JA; Moore, KL (2006). "Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody". J. Biol. Chem. 281 (49): 37877–87. doi: 10.1074/jbc.M609398200 . PMC 1764208 . PMID 17046811.