Brain-specific angiogenesis inhibitor 3

ADGRB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DLO
Identifiers
Aliases	ADGRB3 , BAI3, adhesion G protein-coupled receptor B3
External IDs	OMIM: 602684 MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q12-q13 Start 68,635,282 bp [1] End 69,390,571 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 A5 Start 25,106,557 bp [2] End 25,868,788 bp [2]
RNA expression pattern Bgee Top expressed in middle temporal gyrus endothelial cell Brodmann area 23 orbitofrontal cortex superior frontal gyrus Brodmann area 46 postcentral gyrus entorhinal cortex Region I of hippocampus proper prefrontal cortex More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity GO:0001948 protein binding transmembrane signaling receptor activity signal transducer activity GO:0005097, GO:0005099, GO:0005100 GTPase activator activity Cellular component integral component of membrane plasma membrane membrane postsynapse synaptic cleft intracellular anatomical structure integral component of plasma membrane Biological process negative regulation of angiogenesis G protein-coupled receptor signaling pathway GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity cell surface receptor signaling pathway myoblast fusion signal transduction positive regulation of synapse assembly regulation of dendrite morphogenesis motor learning maintenance of synapse structure neuron remodeling adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	577	210933
Ensembl	ENSG00000135298	ENSMUSG00000033569
UniProt	O60242	Q80ZF8
RefSeq (mRNA)	NM_001704	NM_175642
RefSeq (protein)	NP_001695	NP_783573
Location (UCSC)	Chr 6: 68.64 – 69.39 Mb	Chr 1: 25.11 – 25.87 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene. ^{[5] [6]}

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis. ^[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons. ^[7]

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain. ^[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

References

1. GRCh38: Ensembl release 89: ENSG00000135298 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033569 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenetics and Cell Genetics. 79 (1–2): 103–108. doi:10.1159/000134693. PMID   9533023.
6. "Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
7. Lanoue, V; Usardi, A; Sigoillot, S M; Talleur, M; Iyer, K; Mariani, J; Isope, P; Vodjdani, G; Heintz, N; Selimi, F (2013). "The adhesion-GPCR BAI3, a gene linked to psychiatric disorders, regulates dendrite morphogenesis in neurons". Molecular Psychiatry. 18: 943--950.
8. Bolliger MF, Martinelli DC, Südhof TC (February 2011). "The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins". Proceedings of the National Academy of Sciences of the United States of America. 108 (6): 2534–2539. doi:10.1073/pnas.1019577108. PMID   21262840.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID   12168954.
• Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (1): 31–39. doi: 10.1093/dnares/5.1.31 . PMID   9628581.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID   15203201.

External links

• Human ADGRB3 genome location and ADGRB3 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.