GPR34

GPR34
Identifiers
Aliases	GPR34 , LYPSR1, G protein-coupled receptor 34
External IDs	OMIM: 300241 MGI: 1346334 HomoloGene: 36174 GeneCards: GPR34
Gene location (Human) Chr. X chromosome (human) [1] Band Xp11.4 Start 41,688,973 bp [1] End 41,697,275 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A1.1 Start 13,498,328 bp [2] End 13,507,097 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon smooth muscle tissue placenta right coronary artery appendix gallbladder rectum monocyte adipose tissue left coronary artery Top expressed in Region I of hippocampus proper superior frontal gyrus spleen ankle hippocampus proper white adipose tissue temporal lobe lip nucleus accumbens globus pallidus More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process G protein-coupled receptor signaling pathway signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2857 23890 Ensembl ENSG00000171659 ENSMUSG00000040229 UniProt Q9UPC5 Q9R1K6 RefSeq (mRNA) NM_001033513 NM_001033514 NM_001097579 NM_005300 NM_011823 RefSeq (protein) NP_001091048 NP_005291 NP_035953 Location (UCSC) Chr X: 41.69 – 41.7 Mb Chr X: 13.5 – 13.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene. ^{[5] [6] [7]}

Function

G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000171659 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040229 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Schöneberg T, Schulz A, Grosse R, Schade R, Henklein P, Schultz G, Gudermann T (July 1999). "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (1–2): 57–70. doi:10.1016/s0167-4781(99)00081-0. PMID   10395919.
6. Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF (February 1999). "Discovery of three novel orphan G-protein-coupled receptors". Genomics. 56 (1): 12–21. doi:10.1006/geno.1998.5655. PMID   10036181.
7. "Entrez Gene: GPR34 G protein-coupled receptor 34".

Further reading

• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID   8889549.
• Jacobi FK, Broghammer M, Pesch K, Zrenner E, Berger W, Meindl A, Pusch CM (July 2000). "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics. 107 (1): 89–91. doi:10.1007/s004390050017. PMID   10982042.
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Engemaier E, Römpler H, Schöneberg T, Schulz A (February 2006). "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics. 87 (2): 254–64. doi:10.1016/j.ygeno.2005.10.001. PMID   16338117.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (December 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID   16341674. S2CID   69278.
• Liebscher I, Müller U, Teupser D, Engemaier E, Engel KM, Ritscher L, Thor D, Sangkuhl K, Ricken A, Wurm A, Piehler D, Schmutzler S, Fuhrmann H, Albert FW, Reichenbach A, Thiery J, Schöneberg T, Schulz A (January 2011). "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". The Journal of Biological Chemistry. 286 (3): 2101–10. doi: 10.1074/jbc.M110.196659 . PMC   3023507 . PMID   21097509.
• Ritscher L, Engemaier E, Stäubert C, Liebscher I, Schmidt P, Hermsdorf T, Römpler H, Schulz A, Schöneberg T (May 2012). "The ligand specificity of the G-protein-coupled receptor GPR34". The Biochemical Journal. 443 (3): 841–50. doi:10.1042/BJ20112090. PMID   22348703.