Prokineticin receptor 1

PROKR1
Identifiers
Aliases	PROKR1 , GPR73, GPR73a, PKR1, ZAQ, prokineticin receptor 1, PK-R1
External IDs	OMIM: 607122; MGI: 1929676; HomoloGene: 10968; GeneCards: PROKR1; OMA:PROKR1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.3 Start 68,643,579 bp [1] End 68,658,251 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 D1 Start 87,555,573 bp [2] End 87,567,725 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle ganglionic eminence appendix pituitary gland lactiferous gland anterior pituitary muscle layer of sigmoid colon right adrenal gland hypothalamus Top expressed in lumbar spinal ganglion internal carotid artery external carotid artery inner renal medulla blood epithelium of lens ventricular zone efferent ductule human fetus dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity neuropeptide Y receptor activity pancreatic polypeptide receptor activity G protein-coupled receptor activity Cellular component plasma membrane membrane integral component of membrane integral component of plasma membrane Biological process circadian rhythm negative regulation of apoptotic process signal transduction neuropeptide signaling pathway chemical synaptic transmission feeding behavior blood circulation G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10887 58182 Ensembl ENSG00000169618 ENSMUSG00000049409 UniProt Q8TCW9 Q9JKL1 RefSeq (mRNA) NM_138964 NM_021381 NM_001355655 RefSeq (protein) NP_620414 NP_067356 NP_001342584 Location (UCSC) Chr 2: 68.64 – 68.66 Mb Chr 6: 87.56 – 87.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prokineticin receptor 1, also known as PKR₁, is a human protein encoded by the PROKR1 gene. ^[5]

See also

• Prokineticin receptor

References

1. GRCh38: Ensembl release 89: ENSG00000169618 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049409 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PROKR1 prokineticin receptor 1".

Further reading

• Parker R, Liu M, Eyre HJ, et al. (2000). "Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6". Biochim. Biophys. Acta. 1491 (1–3): 369–75. doi:10.1016/s0167-4781(00)00023-3. PMID   10760605.
• Lin DC, Bullock CM, Ehlert FJ, et al. (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi: 10.1074/jbc.M202139200 . PMID   11886876.
• Masuda Y, Takatsu Y, Terao Y, et al. (2002). "Isolation and identification of EG-VEGF/prokineticins as cognate ligands for two orphan G-protein-coupled receptors". Biochem. Biophys. Res. Commun. 293 (1): 396–402. doi:10.1016/S0006-291X(02)00239-5. PMID   12054613.
• Soga T, Matsumoto S, Oda T, et al. (2003). "Molecular cloning and characterization of prokineticin receptors". Biochim. Biophys. Acta. 1579 (2–3): 173–9. doi:10.1016/S0167-4781(02)00546-8. PMID   12427552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Battersby S, Critchley HO, Morgan K, et al. (2004). "Expression and regulation of the prokineticins (endocrine gland-derived vascular endothelial growth factor and Bv8) and their receptors in the human endometrium across the menstrual cycle". J. Clin. Endocrinol. Metab. 89 (5): 2463–9. doi: 10.1210/jc.2003-032012 . PMID   15126578.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Pasquali D, Rossi V, Staibano S, et al. (2006). "The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy". Endocrinology. 147 (9): 4245–51. doi: 10.1210/en.2006-0614 . PMID   16763065.

External links

• "Prokineticin Receptors: PKR₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2009-07-17. Retrieved 2008-12-09.