TAS2R4

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TAS2R4
Identifiers
Aliases TAS2R4 , T2R4, taste 2 receptor member 4
External IDs OMIM: 604869 MGI: 2681210 HomoloGene: 49480 GeneCards: TAS2R4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016944

NM_020502

RefSeq (protein)

NP_058640

NP_065248

Location (UCSC) Chr 7: 141.78 – 141.78 Mb Chr 6: 40.47 – 40.47 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Taste receptor type 2 member 4 is a protein that in humans is encoded by the TAS2R4 gene. [5] [6] [7]

Contents

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [7] The geographic distribution of TAS2R4 and TAS2R5 missense allele variants which prevent expression of the receptors is aligned with the distributions of tannin sorghum and the destructive agricultural bird pest in Africa, indicating the role of human taste in developing agroecosystems fitting local environments. [8]

Ligands

Ligands listed in BitterDB include quinine, parthenolide, denatonium, some non-sugar sweeteners including sucralose and stevioside, and several oligopeptides. [9]

See also

Related Research Articles

<span class="mw-page-title-main">TAS2R16</span> Protein-coding gene in the species Homo sapiens

TAS2R16 is a human gene that encodes for a receptor that may play a role in the perception of bitterness.

<span class="mw-page-title-main">TAS2R1</span> Member of the 25 known human bitter taste receptors

Taste receptor type 2 member 1 (TAS2R1/T2R1) is a protein that in humans is encoded by the TAS2R1 gene. It belongs to the G protein-coupled receptor (GPCR) family and is related to class A-like GPCRs, they contain 7 transmembrane helix bundles and short N-terminus loop. Furthermore, TAS2R1 is member of the 25 known human bitter taste receptors, which enable the perception of bitter taste in the mouth cavity. Increasing evidence indicates a functional role of TAS2Rs in extra-oral tissues.

<span class="mw-page-title-main">TAS2R3</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.

<span class="mw-page-title-main">TAS2R8</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 8 is a protein that in humans is encoded by the TAS2R8 gene.

<span class="mw-page-title-main">TAS2R9</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.

<span class="mw-page-title-main">TAS2R10</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.

<span class="mw-page-title-main">TAS2R13</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 13 is a protein that in humans is encoded by the TAS2R13 gene.

<span class="mw-page-title-main">TAS2R5</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 5 is a protein that in humans is encoded by the TAS2R5 gene.

<span class="mw-page-title-main">TAS2R7</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 7 is a protein that in humans is encoded by the TAS2R7 gene.

<span class="mw-page-title-main">TAS2R39</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 39 is a protein that in humans is encoded by the TAS2R39 gene.

<span class="mw-page-title-main">TAS2R40</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene.

<span class="mw-page-title-main">TAS2R41</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 41 is a protein that in humans is encoded by the TAS2R41 gene.

<span class="mw-page-title-main">TAS2R43</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 43 is a protein that in humans is encoded by the TAS2R43 gene.

<span class="mw-page-title-main">TAS2R45</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 45 is a protein that in humans is encoded by the TAS2R45 gene.

<span class="mw-page-title-main">TAS2R46</span>

Taste receptor type 2 member 46 is a protein that in humans is encoded by the TAS2R46 gene.

<span class="mw-page-title-main">TAS2R30</span> Protein-coding gene in humans

Taste receptor type 2 member 30 is a protein that in humans is encoded by the TAS2R30 gene.

<span class="mw-page-title-main">TAS2R19</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 19 is a protein that in humans is encoded by the TAS2R19 gene. It seems to be involved in the perception of salt and bitter tastes.

<span class="mw-page-title-main">TAS2R20</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 20 is a protein that in humans is encoded by the TAS2R20 gene.

<span class="mw-page-title-main">TAS2R50</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 50 is a protein that in humans is encoded by the TAS2R50 gene.

<span class="mw-page-title-main">TAS2R60</span> Protein-coding gene in the species Homo sapiens

Taste receptor type 2 member 60 is a protein that in humans is encoded by the TAS2R60 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000127364 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037140 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (March 2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi: 10.1016/S0092-8674(00)80705-9 . PMID   10761934. S2CID   14604586.
  6. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, et al. (March 2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi: 10.1016/S0092-8674(00)80706-0 . PMID   10761935. S2CID   7293493.
  7. 1 2 "Entrez Gene: TAS2R4 taste receptor, type 2, member 4".
  8. Wu Y, Guo T, Mu Q, Wang J, Li X, Wu Y, et al. (December 2019). "Allelochemicals targeted to balance competing selections in African agroecosystems". Nature Plants. 5 (12): 1229–1236. doi:10.1038/s41477-019-0563-0. PMID   31792396. S2CID   208539527.
  9. "hTAS2R4 - Taste receptor type 2 member 4". BitterDB. The Hebrew University of Jerusalem.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.