Thyrotropin-releasing hormone receptor

Last updated
TRHR
Identifiers
Aliases TRHR , TRH-R, thyrotropin releasing hormone receptor, CHNG7
External IDs OMIM: 188545 MGI: 98824 HomoloGene: 20707 GeneCards: TRHR
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003301

NM_013696

RefSeq (protein)

NP_003292

NP_038724

Location (UCSC) Chr 8: 109.09 – 109.12 Mb Chr 15: 44.06 – 44.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone. [5] [6]

Contents

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR is activated it associates with a Gαq/11 protein. The TRHR-G protein complex then activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.

Related Research Articles

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<span class="mw-page-title-main">Thyrotropin-releasing hormone</span> Hormone

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174417 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038760 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID   8128317. S2CID   44982871.
  6. Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression". pp. 341–63. doi:10.1016/B978-0-12-571148-7.50016-6. ISBN   9780125711487. PMID   8382829.{{cite book}}: |journal= ignored (help); Missing or empty |title= (help)

Further reading