Thyrotropin-releasing hormone receptor

Last updated
TRHR
Identifiers
Aliases TRHR , TRH-R, thyrotropin releasing hormone receptor, CHNG7
External IDs OMIM: 188545 MGI: 98824 HomoloGene: 20707 GeneCards: TRHR
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003301

NM_013696

RefSeq (protein)

NP_003292

NP_038724

Location (UCSC) Chr 8: 109.09 – 109.12 Mb Chr 15: 44.06 – 44.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds thyrotropin-releasing hormone. [5] [6]

Contents

The TRHR is found on the cell membrane of thyrotropes of the anterior pituitary. When the TRHR binds TRH it activates phospholipase C, which causes the formation of inositol triphosphate (IP3) and diacylglycerol (DAG). This leads to an increase in cytoplasmic calcium ion concentrations which stimulates the exocytosis of thyroid-stimulating hormone (TSH) into the blood.

Related Research Articles

Thyrotropin-releasing hormone Hormone

Thyrotropin-releasing hormone (TRH) is a hypophysiotropic hormone produced by neurons in the hypothalamus that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin from the anterior pituitary.

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Thyrotropin receptor Mammalian protein found in Homo sapiens

The thyrotropin receptor is a receptor that responds to thyroid-stimulating hormone and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the Gs protein.

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Parathyroid hormone 1 receptor

Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R), is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).

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Corticotropin-releasing hormone receptor 1 Protein-coding gene in the species Homo sapiens

Corticotropin-releasing hormone receptor 1 (CRHR1) is a protein, also known as CRF1, with the latter (CRF1) now being the IUPHAR-recommended name. In humans, CRF1 is encoded by the CRHR1 gene at region 17q21.31, beside micrototubule-associated protein tau MAPT.

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COUP-TFI

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Thyroid hormone receptor beta Protein-coding gene in the species Homo sapiens

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.

Liver X receptor beta Protein-coding gene in the species Homo sapiens

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene.

Corticotropin-releasing hormone receptor 2 Protein-coding gene in the species Homo sapiens

Corticotropin-releasing hormone receptor 2 (CRHR2) is a protein, also known by the IUPHAR-recommended name CRF2, that is encoded by the CRHR2 gene and occurs on the surfaces of some mammalian cells. CRF2 receptors are type 2 G protein-coupled receptors for corticotropin-releasing hormone (CRH) that are resident in the plasma membranes of hormone-sensitive cells. CRH, a peptide of 41 amino acids synthesized in the hypothalamus, is the principal neuroregulator of the hypothalamic-pituitary-adrenal axis, signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors such as adenylate cyclase. The CRF2 receptor is a multi-pass membrane protein with a transmembrane domain composed of seven helices arranged in a V-shape. CRF2 receptors are activated by two structurally similar peptides, urocortin II, and urocortin III, as well as CRH.

Endothelin A receptor Protein-coding gene in the species Homo sapiens

Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.

IGSF1 Protein-coding gene in the species Homo sapiens

Immunoglobulin superfamily, member 1 is a plasma membrane glycoprotein encoded by the IGSF1 gene, which maps to the X chromosome in humans and other mammalian species.

BRD8

Bromodomain-containing protein 8 is a protein that in humans is encoded by the BRD8 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174417 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038760 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yamada M, Monden T, Konaka S, Mori M (November 1993). "Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8". Somatic Cell and Molecular Genetics. 19 (6): 577–80. doi:10.1007/BF01233384. PMID   8128317. S2CID   44982871.
  6. Gershengorn MC (1993). "Thyrotropin-releasing hormone receptor: Cloning and regulation of its expression". Recent Progress in Hormone Research. Vol. 48. pp. 341–63. doi:10.1016/B978-0-12-571148-7.50016-6. ISBN   9780125711487. PMID   8382829.{{cite book}}: Missing or empty |title= (help)

Further reading