GPRC5D

GPRC5D
Identifiers
Aliases	GPRC5D , G protein-coupled receptor, class C, group 5, member D, G protein-coupled receptor class C group 5 member D
External IDs	OMIM: 607437; MGI: 1935037; HomoloGene: 10250; GeneCards: GPRC5D; OMA:GPRC5D - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.1 Start 12,940,575 bp [1] End 12,952,170 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 G1 Start 135,082,989 bp [2] End 135,095,281 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle upper lobe of left lung hair follicle mucosa of transverse colon rectum right lung minor salivary glands bone marrow cells mucosa of esophagus islet of Langerhans Top expressed in lip blastocyst embryo hair follicle skin of abdomen embryo skin of back dermis skin of external ear sexually immature organism More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein kinase activator activity Cellular component integral component of membrane plasma membrane membrane receptor complex intracellular membrane-bounded organelle extracellular exosome Biological process G protein-coupled receptor signaling pathway signal transduction activation of protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55507 93746 Ensembl ENSG00000111291 ENSMUSG00000030205 UniProt Q9NZD1 Q9JIL6 RefSeq (mRNA) NM_018654 NM_001205396 NM_053118 RefSeq (protein) NP_061124 NP_001192325 NP_444348 Location (UCSC) Chr 12: 12.94 – 12.95 Mb Chr 6: 135.08 – 135.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene. ^[5] GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells. ^{[6] [7] [8]}

Structure

Structural analysis of the complex between GPRC5D and talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs. ^[9]

GPRC5D complexed with Talquetamab Fab (PDB: 9IMA)

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. ^[5]

See also

• Retinoic acid-inducible orphan G protein-coupled receptor

References

1. GRCh38: Ensembl release 89: ENSG00000111291 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030205 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPRC5D G protein-coupled receptor, family C, group 5, member D".
6. "The RAIG family member, GPRC5D, is associated with hard-keratinized structures". J. Invest. Dermatol.
7. Smith EL, Harrington K, Staehr M, Masakayan R, Jones J, Long TJ, et al. (March 2019). "GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells". Science Translational Medicine. 11 (485). doi:10.1126/scitranslmed.aau7746. PMC   7508042 . PMID   30918115.
8. Verkleij CP, Broekmans ME, van Duin M, Frerichs KA, Kuiper R, de Jonge AV, et al. (April 2021). "Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma". Blood Advances. 5 (8): 2196–2215. doi:10.1182/bloodadvances.2020003805. PMC   8095149 . PMID   33890981.
9. Jeong J, Park J, Young Mo G, Shin J, Cho Y (August 2024). "Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma" . Journal of Molecular Biology. 436 (20): 168748. doi:10.1016/j.jmb.2024.168748. PMID   39181182.

Further reading

• Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (April 2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1518 (3): 237–248. doi:10.1016/s0167-4781(01)00197-x. PMID   11311935.
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.