GPR174

Last updated

GPR174
Identifiers
Aliases GPR174 , GPCR17, LYPSR3, FKSG79, G protein-coupled receptor 174
External IDs OMIM: 300903; MGI: 2685222; HomoloGene: 13059; GeneCards: GPR174; OMA:GPR174 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032553

NM_001033251
NM_001177781
NM_001177782
NM_001358747

Contents

RefSeq (protein)

NP_115942

NP_001028423
NP_001171252
NP_001171253
NP_001345676

Location (UCSC) Chr X: 79.14 – 79.18 Mb Chr X: 106.3 – 106.34 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene. [5]

Ligands

Agonists
Antagonists

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000147138 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073008 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GPR174 G protein-coupled receptor 174".
  6. Liu G LX (Dec 2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biology. 21 (12): e3002387. doi: 10.1371/journal.pbio.3002387 . PMC   10721165 . PMID   38048360.
  7. Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, et al. (Sep 2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nature Communications. 14 (1) 5901. doi:10.1038/s41467-023-41654-3. PMC   10516915 . PMID   37737235.
  8. Sayama M, Uwamizu A, Ikubo M, Chen L, Yan G, Otani Y, et al. (July 2021). "Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine". Journal of Medicinal Chemistry. 64 (14): 10059–10101. doi:10.1021/acs.jmedchem.1c00347. PMID   34233115.

Further reading