GPR174

GPR174
Identifiers
Aliases	GPR174 , GPCR17, LYPSR3, FKSG79, G protein-coupled receptor 174
External IDs	OMIM: 300903; MGI: 2685222; HomoloGene: 13059; GeneCards: GPR174; OMA:GPR174 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq21.1 Start 79,144,688 bp [1] End 79,175,318 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X D Start 106,299,484 bp [2] End 106,340,375 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus mucosa of ileum lymph node granulocyte appendix epithelium of nasopharynx epithelium of colon spleen superficial temporal artery blood Top expressed in spleen mesenteric lymph nodes blood thymus lumbar spinal ganglion subcutaneous adipose tissue lumbar subsegment of spinal cord granulocyte white adipose tissue dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity bioactive lipid receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process signal transduction G protein-coupled receptor signaling pathway positive regulation of Rho protein signal transduction T cell homeostasis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84636 213439 Ensembl ENSG00000147138 ENSMUSG00000073008 UniProt Q9BXC1 Q3U507 RefSeq (mRNA) NM_032553 NM_001033251 NM_001177781 NM_001177782 NM_001358747 RefSeq (protein) NP_115942 NP_001028423 NP_001171252 NP_001171253 NP_001345676 Location (UCSC) Chr X: 79.14 – 79.18 Mb Chr X: 106.3 – 106.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene. ^[5]

Ligands

Agonists

• GPR174 has been reported to bind to lysophosphatidylserine (LysoPS), and this appears to be the endogenous agonist. ^{[6] [7]}

Antagonists

• N-acyl derivatives of LysoPS act as antagonists at GPR174. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR174 G protein-coupled receptor 174".
6. Liu G LX (Dec 2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biology. 21 (12) e3002387. doi: 10.1371/journal.pbio.3002387 . PMC   10721165 . PMID   38048360.
7. Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, et al. (Sep 2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nature Communications. 14 (1) 5901. doi:10.1038/s41467-023-41654-3. PMC   10516915 . PMID   37737235.
8. Sayama M, Uwamizu A, Ikubo M, Chen L, Yan G, Otani Y, et al. (July 2021). "Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine". Journal of Medicinal Chemistry. 64 (14): 10059–10101. doi:10.1021/acs.jmedchem.1c00347. PMID   34233115.

Further reading

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (Jun 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.