GABBR2

Last updated

GABBR2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases GABBR2 , GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS, DEE59
External IDs OMIM: 607340; MGI: 2386030; HomoloGene: 55902; GeneCards: GABBR2; OMA:GABBR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005458

NM_001081141

RefSeq (protein)

NP_005449

NP_001074610

Location (UCSC) Chr 9: 98.29 – 98.71 Mb Chr 4: 46.66 – 46.99 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Gamma-aminobutyric acid (GABA) B receptor, 2 (GABAB2) is a G-protein coupled receptor subunit encoded by the GABBR2 gene in humans. [5]

Function

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM] [5]

Interactions

GABBR2 has been shown to interact with GABBR1. [6]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000136928 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039809 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2".
  6. White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (Dec 1998). "Heterodimerization is required for the formation of a functional GABA(B) receptor". Nature . 396 (6712): 679–82. Bibcode:1998Natur.396..679W. doi:10.1038/25354. PMID   9872316. S2CID   4406311.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.