TAS2R40

TAS2R40
Identifiers
Aliases	TAS2R40 , GPR60, T2R40, T2R58, taste 2 receptor member 40
External IDs	OMIM: 613964 MGI: 2681312 HomoloGene: 47977 GeneCards: TAS2R40
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q34 Start 143,222,037 bp [1] End 143,223,079 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 42,192,262 bp [2] End 42,193,221 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum blood monocyte sural nerve spleen appendix right lung left uterine tube upper lobe of lung upper lobe of left lung n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity bitter taste receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception of bitter taste signal transduction response to stimulus sensory perception of taste G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 259286 387515 Ensembl ENSG00000221937 ENSMUSG00000051917 UniProt P59535 Q7TQB8 RefSeq (mRNA) NM_176882 NM_001001453 RefSeq (protein) NP_795363 NP_001001453 Location (UCSC) Chr 7: 143.22 – 143.22 Mb Chr 6: 42.19 – 42.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Taste receptor type 2 member 40 is a protein that in humans is encoded by the TAS2R40 gene. ^{[5] [6]}

See also

• Taste receptor

References

1. GRCh38: Ensembl release 89: ENSG00000221937 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051917 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (Oct 2002). "The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides". Nat Genet. 32 (3): 397–401. doi:10.1038/ng1014. PMID   12379855. S2CID   20426192.
6. "Entrez Gene: TAS2R40 taste receptor, type 2, member 40".

Further reading

• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi: 10.1074/jbc.R100054200 . PMID   11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID   12139982. S2CID   37807140.
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi: 10.1016/S0092-8674(03)00071-0 . PMID   12581520. S2CID   718601.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi: 10.1093/molbev/msi027 . PMID   15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC   1449719 . PMID   15744053.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.