GPR116

ADGRF5
Identifiers
Aliases	ADGRF5 , KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928; HomoloGene: 9065; GeneCards: ADGRF5; OMA:ADGRF5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p12.3 Start 46,852,522 bp [1] End 46,954,943 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 B3 Start 43,671,342 bp [2] End 43,770,448 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lower lobe of lung visceral pleura right lung upper lobe of lung upper lobe of left lung renal medulla right ventricle metanephric glomerulus vena cava pericardium Top expressed in right lung right lung lobe left lung lobe endothelial cell of lymphatic vessel interventricular septum myocardium of ventricle extraocular muscle digastric muscle soleus muscle brown adipose tissue More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane cell surface plasma membrane apical part of cell cytoplasmic vesicle membrane Biological process surfactant homeostasis negative regulation of macrophage activation G protein-coupled receptor signaling pathway cell surface receptor signaling pathway energy reserve metabolic process regulation of lipid metabolic process fat cell differentiation positive regulation of phospholipid biosynthetic process glucose homeostasis signal transduction glomerular filtration erythrocyte development pharyngeal arch artery morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 221395 224792 Ensembl ENSG00000069122 ENSMUSG00000056492 UniProt Q8IZF2 G5E8Q8 RefSeq (mRNA) NM_001098518 NM_015234 NM_001081178 NM_001357332 RefSeq (protein) NP_001091988 NP_056049 NP_001074647 NP_001344261 NP_001391458 NP_001391459 NP_001391465 NP_001391470 NP_001391475 NP_001391477 Location (UCSC) Chr 6: 46.85 – 46.95 Mb Chr 17: 43.67 – 43.77 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. ^{[5] [6] [7]} GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN   978-1-4419-7912-4.{{cite book}}: |first= has generic name (help)
6. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
7. "Entrez Gene: GPR116 G protein-coupled receptor 116".
8. Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC   3695742 . PMID   23684610.
9. Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. Bibcode:2013PLoSO...869451F. doi: 10.1371/journal.pone.0069451 . PMC   3726689 . PMID   23922714.

Further reading

• Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID   15203201.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.