GPR116

Last updated
ADGRF5
Identifiers
Aliases ADGRF5 , KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs MGI: 2182928 HomoloGene: 9065 GeneCards: ADGRF5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098518
NM_015234

NM_001081178
NM_001357332

RefSeq (protein)

NP_001091988
NP_056049

Location (UCSC) Chr 6: 46.85 – 46.95 Mb Chr 17: 43.67 – 43.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. [5] [6] [7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis. [8] [9]

Related Research Articles

Latrophilin 1 Protein-coding gene in the species Homo sapiens

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR124 Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR126

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR135

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

GPR123

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR128

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene. GPR128 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR112 Protein-coding gene in the species Homo sapiens

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR113

GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.

GPR125 Protein-coding gene in the species Homo sapiens

Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.

GPR114

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. GPR114 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR115 Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.

GPR97

G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR111 Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.

GPR110

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR133 Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.

GPR150 Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 150 is a protein that in humans is encoded by the GPR150 gene.

GPR144 Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR141

Probable G-protein coupled receptor 141 is a protein that in humans is encoded by the GPR141 gene.

GPR120

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.

GPR142

Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069122 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056492 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN   978-1-4419-7912-4.{{cite book}}: |first= has generic name (help)
  6. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
  7. "Entrez Gene: GPR116 G protein-coupled receptor 116".
  8. Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC   3695742 . PMID   23684610.
  9. Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. Bibcode:2013PLoSO...869451F. doi: 10.1371/journal.pone.0069451 . PMC   3726689 . PMID   23922714.

Further reading