GPR20

GPR20
Identifiers
Aliases	GPR20 , G protein-coupled receptor 20
External IDs	OMIM: 601908; MGI: 2441803; HomoloGene: 3870; GeneCards: GPR20; OMA:GPR20 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.3 Start 141,356,470 bp [1] End 141,367,286 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D3 Start 73,566,453 bp [2] End 73,579,354 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle right coronary artery popliteal artery tibial arteries left coronary artery gastric mucosa smooth muscle tissue Descending thoracic aorta left uterine tube Top expressed in external carotid artery internal carotid artery inner muscle layer large intestine colon Paneth cell embryo left colon primary oocyte duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane receptor complex plasma membrane integral component of plasma membrane membrane Biological process signal transduction positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2843 239530 Ensembl ENSG00000204882 ENSG00000275181 ENSMUSG00000045281 UniProt Q99678 Q8BYC4 RefSeq (mRNA) NM_005293 NM_173365 RefSeq (protein) NP_005284 NP_775541 Location (UCSC) Chr 8: 141.36 – 141.37 Mb Chr 15: 73.57 – 73.58 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 20 is a protein that in humans is encoded by the GPR20 gene. ^{[5] [6]}

References

1. ENSG00000275181 GRCh38: Ensembl release 89: ENSG00000204882, ENSG00000275181 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045281 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hase M, Yokomizo T, Shimizu T, Nakamura M (May 2008). "Characterization of an orphan G protein-coupled receptor, GPR20, that constitutively activates Gi proteins". J Biol Chem. 283 (19): 12747–55. doi: 10.1074/jbc.M709487200 . PMID   18347022.
6. "Entrez Gene: GPR20 G protein-coupled receptor 20".

Further reading

• O'Dowd BF, Nguyen T, Jung BP, et al. (1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID   9073069.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.