GPR6

GPR6
Identifiers
Aliases	GPR6 , G protein-coupled receptor 6
External IDs	OMIM: 600553; MGI: 2155249; HomoloGene: 38026; GeneCards: GPR6; OMA:GPR6 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q21 Start 109,978,256 bp [1] End 109,980,720 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B1|10 22.08 cM Start 40,945,973 bp [2] End 40,948,281 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens putamen caudate nucleus middle frontal gyrus endothelial cell middle temporal gyrus Brodmann area 23 external globus pallidus Pituitary Gland entorhinal cortex Top expressed in dorsal striatum olfactory tubercle nucleus accumbens globus pallidus superior frontal gyrus Temporal Lobe Amygdala mammillary body ventromedial nucleus nucleus of stria terminalis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sphingosine-1-phosphate receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway sphingosine-1-phosphate receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2830 140741 Ensembl ENSG00000146360 ENSMUSG00000046922 UniProt P46095 Q6YNI2 RefSeq (mRNA) NM_005284 NM_001286099 NM_199058 RefSeq (protein) NP_001273028 NP_005275 NP_951013 Location (UCSC) Chr 6: 109.98 – 109.98 Mb Chr 10: 40.95 – 40.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene. ^{[5] [6]}

Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate. ^[7]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth. ^[8]

Ligand

Inverse Agonist

• Cannabidiol ^[9]
• Solangepras (solengepras; CVN-424)

Evolution

Paralogues to GPR6 gene

Source: ^[10]

• GPR3
• GPR12
• S1PR5
• S1PR1
• CNR1
• S1PR2
• LPAR2
• CNR2
• MC1R
• S1PR3
• S1PR4
• GPR119
• MC3R
• MC4R
• MC5R
• LPAR1
• LPAR3
• MC2R

See also

• Lysophospholipid receptor

References

1. GRCh38: Ensembl release 89: ENSG00000146360 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046922 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: GPR6 G protein-coupled receptor 6".
6. Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID   8530049.
7. Uhlenbrock K, Gassenhuber H, Kostenis E (November 2002). "Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors". Cellular Signalling. 14 (11): 941–953. doi:10.1016/S0898-6568(02)00041-4. PMID   12220620.
8. Tanaka S, Ishii K, Kasai K, Yoon SO, Saeki Y (April 2007). "Neural expression of G protein-coupled receptors GPR3, GPR6, and GPR12 up-regulates cyclic AMP levels and promotes neurite outgrowth". The Journal of Biological Chemistry. 282 (14): 10506–10515. doi: 10.1074/jbc.M700911200 . PMID   17284443.
9. Laun AS, Shrader SH, Brown KJ, Song ZH (March 2019). "GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol". Acta Pharmacologica Sinica. 40 (3): 300–308. doi:10.1038/s41401-018-0031-9. PMC   6460361 . PMID   29941868.
10. "GeneCards®: The Human Gene Database".

Further reading

• Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH, et al. (January 1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA and Cell Biology. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID   7832990.
• Song ZH, Modi W, Bonner TI (July 1995). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID   8530049.
• Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E (2003). "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry. 13 (2): 75–84. doi:10.1159/000070251. PMID   12649592. S2CID   45156405.

External links

• "GPR6". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2012-09-02. Retrieved 2009-04-24.