Somatostatin receptor 5

SSTR5
Identifiers
Aliases	SSTR5 , SS-5-R, Somatostatin receptor 5
External IDs	MGI: 894282; HomoloGene: 20287; GeneCards: SSTR5; OMA:SSTR5 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p13.3 Start 1,072,747 bp [1] End 1,081,454 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A3.3|17 12.62 cM Start 25,708,849 bp [2] End 25,716,262 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right auricle of heart apex of heart anterior pituitary right adrenal cortex left ventricle Descending thoracic aorta left adrenal cortex ascending aorta right coronary artery metanephros Top expressed in embryo embryo choroid plexus of fourth ventricle soleus muscle entorhinal cortex superior frontal gyrus primary motor cortex superior colliculus basal forebrain striatum of neuraxis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding G protein-coupled receptor activity signal transducer activity somatostatin receptor activity peptide binding Cellular component integral component of membrane neuron projection plasma membrane integral component of plasma membrane membrane Biological process positive regulation of cytokinesis G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger glucose homeostasis signal transduction negative regulation of cell population proliferation regulation of insulin secretion somatostatin signaling pathway chemical synaptic transmission cellular response to glucocorticoid stimulus neuropeptide signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6755 20609 Ensembl ENSG00000162009 ENSMUSG00000050824 UniProt P35346 O08858 RefSeq (mRNA) NM_001053 NM_001172560 NM_001172572 NM_001172573 NM_001191008 NM_011425 RefSeq (protein) NP_001044 NP_001166031 NP_001177937 NP_035555 Location (UCSC) Chr 16: 1.07 – 1.08 Mb Chr 17: 25.71 – 25.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene. ^[5]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR5 is a member of the superfamily of receptors having seven transmembrane segments. ^[6]

See also

• Somatostatin receptor

References

1. GRCh38: Ensembl release 89: ENSG00000162009 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050824 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takeda J, Fernald AA, Yamagata K, Le Beau MM, Bell GI (Aug 1995). "Localization of human somatostatin receptor 5 gene (SSTR5) to chromosome band 16p13.3 by fluorescence in situ hybridization". Genomics. 26 (3): 638–9. doi:10.1016/0888-7543(95)80195-R. PMID   7607700.
6. "Entrez Gene: SSTR5 somatostatin receptor 5".

Further reading

• Yamada Y, Post SR, Wang K, et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. Bibcode:1992PNAS...89..251Y. doi: 10.1073/pnas.89.1.251 . PMC   48214 . PMID   1346068.
• Montminy MR, Goodman RH, Horovitch SJ, Habener JF (1984). "Primary structure of the gene encoding rat preprosomatostatin". Proc. Natl. Acad. Sci. U.S.A. 81 (11): 3337–40. Bibcode:1984PNAS...81.3337M. doi: 10.1073/pnas.81.11.3337 . PMC   345502 . PMID   6145156.
• Panetta R, Greenwood MT, Warszynska A, et al. (1994). "Molecular cloning, functional characterization, and chromosomal localization of a human somatostatin receptor (somatostatin receptor type 5) with preferential affinity for somatostatin-28". Mol. Pharmacol. 45 (3): 417–27. PMID   7908405.
• O'Carroll AM, Raynor K, Lolait SJ, Reisine T (1994). "Characterization of cloned human somatostatin receptor SSTR5". Mol. Pharmacol. 46 (2): 291–8. PMID   8078491.
• Yamada Y, Kagimoto S, Kubota A, et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. doi:10.1006/bbrc.1993.2122. PMID   8373420.
• Yamada Y, Stoffel M, Espinosa R, et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics. 15 (2): 449–52. doi:10.1006/geno.1993.1088. PMID   8449518.
• Fukusumi S, Kitada C, Takekawa S, et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. doi:10.1006/bbrc.1997.6252. PMID   9125122.
• Ain KB, Taylor KD, Tofiq S, Venkataraman G (1997). "Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines". J. Clin. Endocrinol. Metab. 82 (6): 1857–62. doi: 10.1210/jcem.82.6.4013 . PMID   9177396. S2CID   25337792.
• de Lecea L, Ruiz-Lozano P, Danielson PE, et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics. 42 (3): 499–506. doi:10.1006/geno.1997.4763. PMID   9205124.
• Jaïs P, Terris B, Ruszniewski P, et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. doi:10.1046/j.1365-2362.1997.1740719.x. PMID   9279525. S2CID   23503397.
• Hukovic N, Panetta R, Kumar U, et al. (1998). "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". J. Biol. Chem. 273 (33): 21416–22. doi: 10.1074/jbc.273.33.21416 . PMID   9694905.
• Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. doi: 10.1210/mend.13.1.0220 . PMID   9892014.
• Kumar U, Sasi R, Suresh S, et al. (1999). "Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis". Diabetes. 48 (1): 77–85. doi:10.2337/diabetes.48.1.77. PMID   9892225.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers". J. Biol. Chem. 275 (11): 7862–9. doi: 10.1074/jbc.275.11.7862 . PMID   10713101.
• Rocheville M, Lange DC, Kumar U, et al. (2000). "Receptors for dopamine and somatostatin: formation of hetero-oligomers with enhanced functional activity". Science. 288 (5463): 154–7. Bibcode:2000Sci...288..154R. doi:10.1126/science.288.5463.154. PMID   10753124.
• Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi: 10.1093/hmg/10.4.339 . PMID   11157797.
• Ballarè E, Persani L, Lania AG, et al. (2001). "Mutation of somatostatin receptor type 5 in an acromegalic patient resistant to somatostatin analog treatment". J. Clin. Endocrinol. Metab. 86 (8): 3809–14. doi: 10.1210/jcem.86.8.7787 . PMID   11502816. S2CID   17616592.
• Pasquali D, Notaro A, Esposito D, et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID   11753241.
• Papotti M, Bongiovanni M, Volante M, et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. doi:10.1007/s00428-002-0609-x. PMID   12021920. S2CID   28584328.

External links

• "Somatostatin Receptors: sst₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
• somatostatin+receptor+5 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.