LPAR2

Last updated
LPAR2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LPAR2 , EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs OMIM: 605110 MGI: 1858422 HomoloGene: 3465 GeneCards: LPAR2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004720
NM_001395660

NM_020028

RefSeq (protein)

NP_004711

NP_064412

Location (UCSC) Chr 19: 19.62 – 19.63 Mb Chr 8: 70.28 – 70.28 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene. [5] [6] [7] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA). [8]

Contents

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. [5]

Interactions

LPAR2 has been shown to interact with TRIP6. [9]

Evolution

Paralogues [10] [11]

See also

Related Research Articles

<span class="mw-page-title-main">Lysophosphatidic acid</span> Chemical compound

A lysophosphatidic acid (LPA) is a phospholipid derivative that can act as a signaling molecule.

The lysophospholipid receptor (LPL-R) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans, there are eleven LPL receptors, each encoded by a separate gene. These LPL receptor genes are also sometimes referred to as "Edg".

<span class="mw-page-title-main">Autotaxin</span> Protein-coding gene in the species Homo sapiens

Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 2, is an enzyme that in humans is encoded by the ENPP2 gene.

<span class="mw-page-title-main">S1PR1</span> Protein and coding gene in humans

Sphingosine-1-phosphate receptor 1, also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). S1PR1 was originally identified as an abundant transcript in endothelial cells and it has an important role in regulating endothelial cell cytoskeletal structure, migration, capillary-like network formation and vascular maturation. In addition, S1PR1 signaling is important in the regulation of lymphocyte maturation, migration and trafficking.

<span class="mw-page-title-main">LPAR1</span> Protein

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">S1PR3</span> Protein and coding gene in humans

Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P3.

<span class="mw-page-title-main">LPAR4</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 4 also known as LPA4 is a protein that in humans is encoded by the LPAR4 gene. LPA4 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">S1PR4</span> Protein-coding gene in the species Homo sapiens

Sphingosine-1-phosphate receptor 4 also known as S1PR4 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P4.

<span class="mw-page-title-main">S1PR2</span> Protein and coding gene in humans

Sphingosine-1-phosphate receptor 2, also known as S1PR2 or S1P2, is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P).

<span class="mw-page-title-main">LPAR6</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 6, also known as LPA6, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">S1PR5</span> Protein-coding gene in the species Homo sapiens

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P5.

<span class="mw-page-title-main">LPAR5</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene. LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">LPAR3</span> Protein-coding gene in the species Homo sapiens

Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene. LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

<span class="mw-page-title-main">PRKD3</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase D3 (PKD3) or PKC-nu is an enzyme that in humans is encoded by the PRKD3 gene.

<span class="mw-page-title-main">TRIP6</span> Protein-coding gene in the species Homo sapiens

Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene.

<span class="mw-page-title-main">Tyrosine-protein kinase BLK</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. It is of the Src family of tyrosine kinases.

<span class="mw-page-title-main">TRAP1</span> Protein-coding gene in the species Homo sapiens

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.

<span class="mw-page-title-main">AGPAT1</span> Protein-coding gene in the species Homo sapiens

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha is an enzyme that in humans is encoded by the AGPAT1 gene.

<span class="mw-page-title-main">LIPH (gene)</span> Protein-coding gene in the species Homo sapiens

Lipase member H is an enzyme that in humans is encoded by the LIPH gene.

<span class="mw-page-title-main">AGPAT9</span> Mammalian protein found in Homo sapiens

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene. GPAT-3 is also known as:

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000064547 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031861 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
  6. An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi: 10.1074/jbc.273.14.7906 . PMID   9525886.
  7. An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID   9804623. S2CID   37327084.
  8. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID   20055701.
  9. Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11). United States: 10459–68. doi: 10.1074/jbc.M311891200 . ISSN   0021-9258. PMC   3904432 . PMID   14688263.
  10. "GeneCards®: The Human Gene Database".
  11. "Ensembl Genome Browser".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.