LPAR2

LPAR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4P0C
Identifiers
Aliases	LPAR2 , EDG-4, EDG4, LPA-2, LPA2, lysophosphatidic acid receptor 2
External IDs	OMIM: 605110; MGI: 1858422; HomoloGene: 3465; GeneCards: LPAR2; OMA:LPAR2 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.11 Start 19,623,655 bp [1] End 19,628,930 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 B3.3|8 33.91 cM Start 70,275,079 bp [2] End 70,283,752 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone granulocyte blood right testis spleen left testis monocyte mucosa of transverse colon right lung Top expressed in granulocyte yolk sac epiblast tail of embryo otic vesicle genital tubercle ventricular zone ganglion of vagus nerve primitive streak placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding protein binding lysophosphatidic acid receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of plasma membrane membrane endocytic vesicle integral component of membrane plasma membrane cell surface Biological process activation of phospholipase C activity signal transduction positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9170 53978 Ensembl ENSG00000064547 ENSMUSG00000031861 UniProt Q9HBW0 Q9JL06 Q6P290 RefSeq (mRNA) NM_004720 NM_001395660 NM_020028 RefSeq (protein) NP_004711 NP_064412 Location (UCSC) Chr 19: 19.62 – 19.63 Mb Chr 8: 70.28 – 70.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. ^{[5] [6] [7]} LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA). ^[8]

Function

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca²⁺ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. ^[5]

Interactions

LPAR2 has been shown to interact with TRIP6. ^[9]

Evolution

Paralogues

Source: ^{[10] [11]}

• LPAR1
• LPAR3
• S1PR1
• S1PR5
• S1PR4
• S1PR2
• S1PR3
• GPR6
• GPR3
• GPR12
• MC4R
• MC5R
• CNR1
• MC3R
• CNR2
• MC1R
• GPR119
• MC2R

See also

• Lysophospholipid receptor

References

1. GRCh38: Ensembl release 89: ENSG00000064547 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031861 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2".
6. An S, Bleu T, Hallmark OG, Goetzl EJ (April 1998). "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. doi: 10.1074/jbc.273.14.7906 . PMID   9525886.
7. An S, Bleu T, Zheng Y, Goetzl EJ (November 1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. doi:10.1124/mol.54.5.881. PMID   9804623. S2CID   37327084.
8. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID   20055701.
9. Xu J, Lai Yun-Ju, Lin Weei-Chin, Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11). United States: 10459–68. doi: 10.1074/jbc.M311891200 . ISSN   0021-9258. PMC   3904432 . PMID   14688263.
10. "GeneCards®: The Human Gene Database".
11. "Ensembl Genome Browser".

Further reading

• Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 54–60. Bibcode:2000NYASA.905...54S. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID   10818441. S2CID   9257870.
• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. doi:10.1124/mol.58.6.1188. PMID   11093753. S2CID   6936621.
• Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID   10537322.
• Contos JJ, Chun J (2000). "Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA". Genomics. 64 (2): 155–69. doi:10.1006/geno.2000.6122. PMID   10729222.
• Bandoh K, Aoki J, Taira A, et al. (2000). "Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors". FEBS Lett. 478 (1–2): 159–65. doi: 10.1016/S0014-5793(00)01827-5 . PMID   10922489. S2CID   21584151.
• Young KW, Bootman MD, Channing DR, et al. (2001). "Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors". J. Biol. Chem. 275 (49): 38532–9. doi: 10.1074/jbc.M006631200 . PMID   10954727.
• Zheng Y, Voice JK, Kong Y, Goetzl EJ (2001). "Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes". FASEB J. 14 (15): 2387–9. doi: 10.1096/fj.00-0492fje . PMID   11024010. S2CID   24778289.
• Hama K, Bandoh K, Kakehi Y, et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1–3): 187–92. doi: 10.1016/S0014-5793(02)02976-9 . PMID   12123830. S2CID   44924895.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Fujita T, Miyamoto S, Onoyama I, et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer". Cancer Lett. 192 (2): 161–9. doi:10.1016/S0304-3835(02)00713-9. PMID   12668280.
• Hu YL, Albanese C, Pestell RG, Jaffe RB (2003). "Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells". J. Natl. Cancer Inst. 95 (10): 733–40. doi: 10.1093/jnci/95.10.733 . PMID   12759391.
• Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11): 10459–68. doi: 10.1074/jbc.M311891200 . PMC   3904432 . PMID   14688263.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Oh YS, Jo NW, Choi JW, et al. (2004). "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation". Mol. Cell. Biol. 24 (11): 5069–79. doi:10.1128/MCB.24.11.5069-5079.2004. PMC   416407 . PMID   15143197.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• "Lysophospholipid Receptors: LPA₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-05.
• Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.