Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene. [5]
Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene. [5]
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [5]
H2 receptors are positively coupled to adenylate cyclase via Gs alpha subunit. It is a potent stimulant of cAMP production, which leads to activation of protein kinase A. PKA functions to phosphorylate certain proteins, affecting their activity. The drug betazole is an example of a histamine H2 receptor agonist.
The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member of the secretin receptor family, also called class B GPCR subfamily.
The cholecystokinin B receptor also known as CCKBR or CCK2 is a protein that in humans is encoded by the CCKBR gene.
P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.
Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene. It is a member of the adhesion-GPCR family of receptors.
Chemokine like receptor 1 also known as ChemR23 is a protein that in humans is encoded by the CMKLR1 gene. Chemokine receptor-like 1 is a G protein-coupled receptor for the chemoattractant adipokine chemerin and the omega-3 fatty acid eicosapentaenoic acid-derived specialized pro-resolving molecule, resolvin E1. The murine receptor that shares almost 80% homology with the human receptor, is called Dez.
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.
Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene.
Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.
Melanocortin 5 receptor (MC5R) is a protein that in humans is encoded by the MC5R gene. It is located on the chromosome 18 in the human genome. When the MC5R was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.
P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.
Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.
Galanin receptor 3 (GAL3) is a G-protein coupled receptor encoded by the GALR3 gene.
Galanin receptor 2, (GAL2) is a G-protein coupled receptor encoded by the GALR2 gene.
Probable G-protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene.
Frizzled-10(Fz-10) is a protein that in humans is encoded by the FZD10 gene. Fz-10 has also been designated as CD350.
G-protein coupled receptor 139 (GPC139) is a protein that in humans is encoded by the GPR139 gene. Research has shown that mice with loss of GCP139 experience schizophrenia-like symptomatology that is rescued with the dopamine receptor antagonist haloperidol and the μ-opioid receptor antagonist naltrexone.
Vasoactive intestinal polypeptide receptor 1 also known as VPAC1, is a protein, that in humans is encoded by the VIPR1 gene. VPAC1 is expressed in the brain (cerebral cortex, hippocampus, amygdala), lung, prostate, peripheral blood leukocytes, liver, small intestine, heart, spleen, placenta, kidney, thymus and testis.
Zinc finger protein 318 is a protein that in humans is encoded by the ZNF318 gene.
Two pore segment channel 1 (TPC1) is a human protein encoded by the TPCN1 gene. The protein encoded by this gene is an ion channel. In contrast to other calcium and sodium channels which have four homologous domains, each containing 6 transmembrane segments, TPCN1 only contains two domains.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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