Galanin receptor 1

Last updated
GALR1
Identifiers
Aliases GALR1 , GALNR, GALNR1, Galanin receptor 1
External IDs OMIM: 600377 MGI: 1096364 HomoloGene: 74396 GeneCards: GALR1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001480

NM_008082

RefSeq (protein)

NP_001471

NP_032108

Location (UCSC) Chr 18: 77.25 – 77.28 Mb Chr 18: 82.41 – 82.42 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Galanin receptor 1 (GAL1) is a G-protein coupled receptor encoded by the GALR1 gene. [5]

Contents

Function

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [5]

See also

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166573 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024553 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: GALR1 galanin receptor 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.