GPR101

GPR101
Identifiers
Aliases	GPR101 , GPCR6, PAGH2, G protein-coupled receptor 101, PITA2
External IDs	OMIM: 300393 MGI: 2685211 HomoloGene: 14273 GeneCards: GPR101
Gene location (Human) Chr. X chromosome (human) [1] Band Xq26.3 Start 137,023,929 bp [1] End 137,033,995 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A6 Start 56,542,028 bp [2] End 56,549,117 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus hypothalamus putamen cerebellum cerebellar cortex cerebellar hemisphere spinal cord temporal lobe amygdala Top expressed in arcuate nucleus paraventricular nucleus of hypothalamus subiculum median eminence dorsomedial hypothalamic nucleus ventromedial nucleus nucleus accumbens supraoptic nucleus mammillary body lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity adrenergic receptor activity Cellular component integral component of membrane receptor complex plasma membrane integral component of plasma membrane membrane intracellular anatomical structure Biological process adenylate cyclase-activating adrenergic receptor signaling pathway cell-cell signaling G protein-coupled receptor signaling pathway signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83550 245424 Ensembl ENSG00000165370 ENSMUSG00000036357 UniProt Q96P66 Q80T62 RefSeq (mRNA) NM_054021 NM_001033360 RefSeq (protein) NP_473362 NP_001028532 Location (UCSC) Chr X: 137.02 – 137.03 Mb Chr X: 56.54 – 56.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 101 is a protein that in humans is encoded by the GPR101 gene. ^{[5] [6]}

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. ^[6]

Clinical significance

A duplication event in GPR101 is implicated in cases of gigantism and acromegaly. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000165370 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036357 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene. 275 (1): 83–91. doi:10.1016/S0378-1119(01)00651-5. PMID   11574155.
6. "Entrez Gene: GPR101 G protein-coupled receptor 101".
7. Trivellin G, Daly AF, Faucz FR, Yuan B, Rostomyan L, Larco DO, Schernthaner-Reiter MH, Szarek E, Leal LF, Caberg JH, Castermans E, Villa C, Dimopoulos A, Chittiboina P, Xekouki P, Shah N, Metzger D, Lysy PA, Ferrante E, Strebkova N, Mazerkina N, Zatelli MC, Lodish M, Horvath A, de Alexandre RB, Manning AD, Levy I, Keil MF, Sierra MD, Palmeira L, Coppieters W, Georges M, Naves LA, Jamar M, Bours V, Wu TJ, Choong CS, Bertherat J, Chanson P, Kamenický P, Farrell WE, Barlier A, Quezado M, Bjelobaba I, Stojilkovic SS, Wess J, Costanzi S, Liu P, Lupski JR, Beckers A, Stratakis CA (2014). "Gigantism and Acromegaly Due to Xq26 Microduplications and GPR101 Mutation". N. Engl. J. Med. 371 (25): 2363–74. doi:10.1056/NEJMoa1408028. PMC   4291174 . PMID   25470569.

Further reading

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.