GPR123

Last updated
ADGRA1
Identifiers
Aliases ADGRA1 , GPR123, adhesion G protein-coupled receptor A1
External IDs OMIM: 612302 MGI: 1277167 HomoloGene: 18582 GeneCards: ADGRA1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001083909
NM_001291085
NM_032422

NM_177469

RefSeq (protein)

NP_001077378
NP_001278014

NP_803420

Location (UCSC) Chr 10: 133.09 – 133.13 Mb Chr 7: 139.41 – 139.46 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. [5] [6] It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [7] [8] [9]

Related Research Articles

<span class="mw-page-title-main">Latrophilin 1</span> Protein-coding gene in the species Homo sapiens

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR124</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR126</span>

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR135</span>

Probable G-protein coupled receptor 135 is a protein that in humans is encoded by the GPR135 gene.

<span class="mw-page-title-main">GPR128</span>

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene. GPR128 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR112</span> Protein-coding gene in the species Homo sapiens

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR113</span>

GPR113 is a gene that encodes the Probable G-protein coupled receptor 113 protein.

<span class="mw-page-title-main">GPR125</span> Protein-coding gene in the species Homo sapiens

Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.

<span class="mw-page-title-main">GPR114</span>

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. GPR114 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR115</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 115 is a protein that in humans is encoded by the GPR115 gene.

<span class="mw-page-title-main">GPR116</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene. GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.

<span class="mw-page-title-main">GPR97</span>

G-protein coupled receptor 97 also known as adhesion G protein-coupled receptor G3 (ADGRG3) is a protein that in humans is encoded by the ADGRG3 gene. GPR97 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR111</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.

<span class="mw-page-title-main">GPR110</span>

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR133</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.

<span class="mw-page-title-main">Relaxin/insulin-like family peptide receptor 4</span>

Relaxin/insulin-like family peptide receptor 4, also known as RXFP4, is a human G-protein coupled receptor.

<span class="mw-page-title-main">GPR144</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

<span class="mw-page-title-main">GPR141</span>

Probable G-protein coupled receptor 141 is a protein that in humans is encoded by the GPR141 gene.

<span class="mw-page-title-main">GPR120</span> Protein-coding gene in the species Homo sapiens

G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.

<span class="mw-page-title-main">GPR142</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 142 is a protein that in humans is encoded by the GPR142 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000197177 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025475 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID   12565841.
  6. "Entrez Gene: GPR123 G protein-coupled receptor 123".
  7. Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN   978-1-4419-7912-4.
  8. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
  9. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC   3321182 . PMID   22333914.

Further reading