GPR123

ADGRA1
Identifiers
Aliases	ADGRA1 , GPR123, adhesion G protein-coupled receptor A1
External IDs	OMIM: 612302 MGI: 1277167 HomoloGene: 18582 GeneCards: ADGRA1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.3 Start 133,087,924 bp [1] End 133,131,675 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 F4|7 84.89 cM Start 139,414,090 bp [2] End 139,458,004 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 9 cingulate gyrus prefrontal cortex hypothalamus amygdala middle temporal gyrus ganglionic eminence hippocampus proper superior frontal gyrus Brodmann area 23 Top expressed in facial motor nucleus medial dorsal nucleus substantia nigra lateral geniculate nucleus medial geniculate nucleus subiculum amygdala anterior horn of spinal cord hypothalamus supraoptic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane membrane postsynaptic density glutamatergic synapse Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84435 52389 Ensembl ENSG00000197177 ENSMUSG00000025475 UniProt Q86SQ6 Q8C4G9 RefSeq (mRNA) NM_001083909 NM_001291085 NM_032422 NM_177469 RefSeq (protein) NP_001077378 NP_001278014 NP_803420 Location (UCSC) Chr 10: 133.09 – 133.13 Mb Chr 7: 139.41 – 139.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. ^{[5] [6]} It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. ^{[7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000197177 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025475 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fredriksson R, Gloriam DE, Hoglund PJ, Lagerstrom MC, Schioth HB (Feb 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochem Biophys Res Commun. 301 (3): 725–34. doi:10.1016/S0006-291X(03)00026-3. PMID   12565841.
6. "Entrez Gene: GPR123 G protein-coupled receptor 123".
7. Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN   978-1-4419-7912-4.
8. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
9. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC   3321182 . PMID   22333914.

Further reading

• Vassilatis DK, Hohmann JG, Zeng H, et al. (2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID   15203201.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.