Latrophilin 2

ADGRL2
Identifiers
Aliases	ADGRL2 , CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
External IDs	OMIM: 607018 MGI: 2139714 HomoloGene: 22712 GeneCards: ADGRL2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	81,993,932 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	148,990,555 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; gastric mucosa; ; lower lobe of lung; ; ganglionic eminence; ; Achilles tendon; ; gallbladder; ; minor salivary gland;
	Top expressed in
	hand; ; maxillary prominence; ; left lung lobe; ; renal corpuscle; ; skin of back; ; stria vascularis; ; belly cord; ; ventromedial nucleus; ; abdominal wall; ; otolith organ;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity ; transmembrane signaling receptor activity ; latrotoxin receptor activity ; signal transducer activity ; carbohydrate binding ;
Cellular component	integral component of membrane ; membrane ; intracellular anatomical structure ; integral component of plasma membrane ; neuron projection ;
Biological process	G protein-coupled receptor signaling pathway ; cell surface receptor signaling pathway ; signal transduction ; adenylate cyclase-activating G protein-coupled receptor signaling pathway ; brain development ;
	Sources:Amigo / QuickGO
Orthologs
	23266
	99633
	ENSG00000117114
	ENSMUSG00000028184
	O95490
	Q8JZZ7
NM_001297704 ; NM_001297705 ; NM_001297706 ; NM_012302 ; NM_001330645 ;
	NM_001350698 ; NM_001350699 ; NM_001366002 ; NM_001366003 ; NM_001366004 ; NM_001366005 ; NM_001366006 ; NM_001366007 ; NM_001366008 ; NM_001366009 ; NM_001393349 ; NM_001393350 ; NM_001393351 ; NM_001393352 ; NM_001393353 ; NM_001393354 Contents See also ; References ; Further reading ;
	NM_001081298
NP_001284633 ; NP_001284634 ; NP_001284635 ; NP_001317574 ; NP_036434 ;
	NP_001337627 ; NP_001337628 ; NP_001352931 ; NP_001352932 ; NP_001352933 ; NP_001352934 ; NP_001352935 ; NP_001352936 ; NP_001352937 ; NP_001352938
NP_001074767 ; NP_001392915 ; NP_001392916 ; NP_001392917 ; NP_001392918 ;
	NP_001392919 ; NP_001392920 ; NP_001392921 ; NP_001392922 ; NP_001392923 ; NP_001392924 ; NP_001392925 ; NP_001392926 ; NP_001392927 ; NP_001392928 ; NP_001392929 ; NP_001392930 ; NP_001392931 ; NP_001392932 ; NP_001392933 ; NP_001392934 ; NP_001392935 ; NP_001392936 ; NP_001392937 ; NP_001392938 ; NP_001392939 ; NP_001392940 ; NP_001392947 ; NP_001392948
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.^[5]^[6]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.^[6]

Related Research Articles

A latrotoxin is a high-molecular mass neurotoxin found in the venom of spiders of the genus Latrodectus as well as at least one species of another genus in the same family, Steatoda nobilis. Latrotoxins are the main active components of the venom and are responsible for the symptoms of latrodectism.

ADGRV1, also known as G protein-coupled receptor 98 (GPR98) or Very Large G-protein coupled receptor 1 (VLGR1), is a protein that in humans is encoded by the GPR98 gene. Several alternatively spliced transcripts have been described.

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors.

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene.

G protein-coupled receptor 126 also known as VIGR and DREG is a protein encoded by the ADGRG6 gene. GPR126 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene. GPR114 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.

Probable G-protein coupled receptor 144 is a protein that in humans is encoded by the GPR144 gene. This gene encodes a member of the adhesion-GPCR family of receptors. Family members are characterised by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

EGF, latrophilin and seven transmembrane domain-containing protein 1 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ELTD1 gene. ELTD1 appears to have a role in angiogenesis, both physiological and pathological in cancer.

Neuronal acetylcholine receptor subunit alpha-4, also known as nAChRα4, is a protein that in humans is encoded by the CHRNA4 gene. The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAChR). Alpha4-containing nAChRs appear to play a crucial role in the addictive response to nicotine..

Olfactory receptor 2H2 is a protein that in humans is encoded by the OR2H2 gene.

Olfactory receptor 2M4 is a protein that in humans is encoded by the OR2M4 gene.

Olfactory receptor 13C4 is a protein that in humans is encoded by the OR13C4 gene.

Olfactory receptor 9Q1 is a protein that in humans is encoded by the OR9Q1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.
1 2 "Entrez Gene: LPHN2 latrophilin 2".

Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins". Annual Review of Neuroscience. 24 (1): 933–62. doi:10.1146/annurev.neuro.24.1.933. PMID 11520923.
Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies". Toxicon. 43 (5): 527–42. doi:10.1016/j.toxicon.2004.02.008. PMID 15066411.
Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID 9872452.
White GR, Varley JM, Heighway J (Dec 1998). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer". Oncogene. 17 (26): 3513–9. doi: 10.1038/sj.onc.1202487 . PMID 10030676.
Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins". The Journal of Biological Chemistry. 275 (42): 32387–90. doi: 10.1074/jbc.C000490200 . PMID 10964907.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays". Genome Biology. 8 (4): R64. doi: 10.1186/gb-2007-8-4-r64 . PMC 1896007 . PMID 17456239.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10760572-5] White GR, Varley JM, Heighway J (Apr 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1491 (1–3): 75–92. doi:10.1016/s0167-4781(00)00020-8. PMID 10760572.

[entrez-6] 1 2 "Entrez Gene: LPHN2 latrophilin 2".

[1]

[2]

[3]

[4]

[5]

[6]

Latrophilin 2

Contents

See also

Related Research Articles

References

Further reading