Latrophilin 3

Last updated
ADGRL3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ADGRL3 , CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDs OMIM: 616417 MGI: 2441950 HomoloGene: 22878 GeneCards: ADGRL3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC) Chr 4: 61.2 – 62.08 Mb Chr 5: 81.02 – 81.83 Mb
PubMed search [3] [4]
Wikidata
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Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene. [5] [6]

Function

This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [6]

Clinical significance

A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD). [7]

See also

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000150471 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037605 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hayflick JS (Jan 2001). "A family of heptahelical receptors with adhesion-like domains: a marriage between two super families". Journal of Receptor and Signal Transduction Research. 20 (2–3): 119–31. doi:10.3109/10799890009150640. PMID   10994649. S2CID   19919738.
  6. 1 2 "Entrez Gene: LPHN3 latrophilin 3".
  7. Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, et al. (Nov 2010). "A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts the effectiveness of stimulant medication". Molecular Psychiatry. 15 (11): 1053–66. doi: 10.1038/mp.2010.6 . hdl: 11336/80502 . PMID   20157310.

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.