Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene. [5] [6]
Latrophilin 3 is a protein that in humans is encoded by the ADGRL3 gene. [5] [6]
This gene encodes a member of the latrophilin subfamily of G protein-coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [6]
A version of this gene has been linked to attention deficit hyperactivity disorder (ADHD). [7]
The Gs alpha subunit is a subunit of the heterotrimeric G protein Gs that stimulates the cAMP-dependent pathway by activating adenylyl cyclase. Gsα is a GTPase that functions as a cellular signaling protein. Gsα is the founding member of one of the four families of heterotrimeric G proteins, defined by the alpha subunits they contain: the Gαs family, Gαi/Gαo family, Gαq family, and Gα12/Gα13 family. The Gs-family has only two members: the other member is Golf, named for its predominant expression in the olfactory system. In humans, Gsα is encoded by the GNAS complex locus, while Golfα is encoded by the GNAL gene.
Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors.
Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Probable G-protein coupled receptor 123 is a protein that in humans is encoded by the GPR123 gene. It is a member of the adhesion-GPCR family of receptors. Family members are normally characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Adhesion G-protein coupled receptor A3 (ADGRA3), also known as GPR125, is an adhesion GPCR that in humans is encoded by the Adgra3 gene.
Probable G-protein coupled receptor 111 is a protein that in humans is encoded by the GPR111 gene.
Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.
Probable G-protein coupled receptor 133 is a protein that in humans is encoded by the GPR133 gene.
Secretin receptor family consists of secretin receptors regulated by peptide hormones from the glucagon hormone family. The family is different from adhesion G protein-coupled receptors.
Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin. This conserved family of membrane proteins has up to three homologues in chordate species, including humans.
Latrophilin 2 is a protein that in humans is encoded by the ADGRL2 gene.
Olfactory receptor 10H2 is a protein that in humans is encoded by the OR10H2 gene.
Olfactory receptor 10H3 is a protein that in humans is encoded by the OR10H3 gene.
Olfactory receptor, family 12, subfamily D, member 2, also known as OR12D2, is a protein which in humans is encoded by the OR12D2 gene.
Olfactory receptor 7C2 is a protein that in humans is encoded by the OR7C2 gene.
Olfactory receptor 2A4 is a protein that in humans is encoded by the OR2A4 gene.
Olfactory receptor 5P2 is a protein that in humans is encoded by the OR5P2 gene.
Olfactory receptor 9Q1 is a protein that in humans is encoded by the OR9Q1 gene.
Olfactory receptor 6C3 is a protein that in humans is encoded by the OR6C3 gene.
The Glycine receptor subunit alpha-3 is a protein that in humans is encoded by the GLRA3 gene. The protein encoded by this gene is a subunit of the glycine receptor.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. |