Latrophilin

Latrophilin
Identifiers
Symbol	Latrophilin
Pfam	PF02354
InterPro	IPR003334
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

EGF, latrophilin and seven transmembrane domain containing 1
Identifiers
Symbol	ELTD1
Alt. symbols	ETL
NCBI gene	64123
HGNC	20822
RefSeq	NM_022159
UniProt	Q9HBW9
Other data
Locus	Chr. 1 p33-p32
Search for Structures Swiss-model Domains InterPro

latrophilin 1
Identifiers
Symbol	LPHN1
Alt. symbols	KIAA0821, CIRL1, LEC2
NCBI gene	22859
HGNC	20973
RefSeq	NM_014921
UniProt	O94910
Other data
Locus	Chr. 19 p13.2
Search for Structures Swiss-model Domains InterPro

latrophilin 2
Identifiers
Symbol	LPHN2
Alt. symbols	LPHH1, KIAA0786, LEC1
NCBI gene	23266
HGNC	18582
OMIM	607018
RefSeq	NM_012302
UniProt	O95490
Other data
Locus	Chr. 1 p31.1
Search for Structures Swiss-model Domains InterPro

latrophilin 3
Identifiers
Symbol	LPHN3
Alt. symbols	KIAA0768, LEC3
NCBI gene	23284
HGNC	20974
RefSeq	NM_015236
UniProt	Q9HAR2
Other data
Locus	Chr. 4 q13.1
Search for Structures Swiss-model Domains InterPro

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin. ^[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans. ^[2]

The precise functions of latrophilins remain unknown. ^[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer. ^[3]

Human proteins containing this domain

• Latrophilin 1 (LPHN1)
• Latrophilin 2 (LPHN2)
• Latrophilin 3 (LPHN3)

See also

• ELTD1

References

1. Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins" . Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID   12196116.
2. Silva, JP; Ushkaryov, YA (2010). "The Latrophilins, "Split-Personality" Receptors". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 59–75. doi:10.1007/978-1-4419-7913-1_5. ISBN   978-1-4419-7912-4. PMC   3145135 . PMID   21618826.
3. Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6): 457–478. doi: 10.1515/bmc-2014-0032 . PMID   25429599. S2CID   207442054.