Neostigmine is a medication used to treat myasthenia gravis, Ogilvie syndrome, and urinary retention without the presence of a blockage. It is also used together with atropine to end the effects of neuromuscular blocking medication of the non-depolarizing type. It is given by injection either into a vein, muscle, or under the skin. After injection effects are generally greatest within 30 minutes and last up to 4 hours.
ATC code N07Other nervous system drugs is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products. Subgroup N07 is part of the anatomical group N Nervous system.
Vecuronium bromide, sold under the brand name Norcuron among others, is a medication used as part of general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is also used to help with endotracheal intubation; however, suxamethonium (succinylcholine) is generally preferred if this needs to be done quickly. It is given by injection into a vein. Effects are greatest at about 4 minutes and last for up to an hour.
The Nardi test, also known as the morphine-neostigmine provocation test is a test for dysfunction of the sphincter of Oddi, a valve which divides the biliary tract from the duodenum. Two medications, morphine and neostigmine, are given to people with symptoms concerning for sphincter dysfunction, including sharp right-sided abdominal pain. If the pain is reproduced by the medications, then dysfunction is more likely. The test poorly predicts dysfunction, however, and is rarely used today. The Nardi test was named for George Nardi, who first described the procedure in 1966.
Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia to facilitate tracheal intubation by providing skeletal muscle relaxation, most commonly required for surgery or mechanical ventilation. It is used for standard endotracheal intubation, as well as for rapid sequence induction (RSI).
Ogilvie syndrome is the acute dilatation of the colon in the absence of any mechanical obstruction in severely ill patients.
Sugammadex, sold under the brand name Bridion, is a medication for the reversal of neuromuscular blockade induced by rocuronium and vecuronium in general anaesthesia. It is the first selective relaxant binding agent (SRBA).
Distigmine is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.
Stigmine refers to a class of acetylcholinesterase inhibitors.
Gheorghe "Gigi" Mulțescu is a Romanian professional football manager and a former football player.
Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.
Toxiferine is a curare toxin. It is a bisindole alkaloid derived from Strychnos toxifera and a nicotinic acetylcholine receptor antagonist. This alkaloid is the main toxic component of Calabash curare, and one of the most toxic plant alkaloids known. The lethal dose (LD50) for mice has been determined as 10 - 60 µg/kg by intravenous administration. It is a muscle relaxant that causes paralysis of skeletal muscle, which takes approximately 2 hours to recovery for a moderate dose, and 8 hours of total paralysis with a 20-fold paralytic dose. The paralysis can be antagonized by Neostigmine
Postoperative residual curarization (PORC) or residual neuromuscular blockade (RNMB) is a residual paresis after emergence from general anesthesia that may occur with the use of neuromuscular-blocking drugs. Today residual neuromuscular blockade is defined as a train of four ratio of less than 0.9 when measuring the response to ulnar nerve stimulation at the adductor pollicis muscle using mechanomyography or electromyography. A meta-analysis reported that the incidence of residual neuromuscular paralysis was 41% in patients receiving intermediate neuromuscular blocking agents during anaesthesia. It is possible that > 100,000 patients annually in the USA alone, are at risk of adverse events associated with undetected residual neuromuscular blockade. Neuromuscular function monitoring and the use of the appropriate dosage of sugammadex to reverse blockade produced by rocuronium can reduce the incidence of postoperative residual curarization. In this study, with usual care group receiving reversal with neostigmine resulted in a residual blockade rate of 43%.
Fotbal Club Politehnica Timișoara, commonly referred to as Poli Timișoara, was a Romanian football club established in 1921 and dissolved in September 2012. The team had won two Romanian Cups and was twice a runner-up in Liga I. It is ranked eighth in the Liga I All-Time Table, with 49 seasons played.
The 1951 Cupa României Final was the 14th final of Romania's most prestigious football cup competition. It was disputed between CCA București and Flacăra Mediaş, and was won by CCA București after a game with 4 goals. It was the third cup title in the history of CCA București.
T-1123 is a carbamate-based acetylcholinesterase inhibitor. It was investigated as a chemical warfare agent starting in 1940. It does not go through the blood-brain barrier due to the charge on quaternary nitrogen. The antidote is atropine. T-1123 is a quaternary ammonium ion. A phenyl carbamate ester is bonded in the meta position to the nitrogen on a diethylmethyl amine.
Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD50 is 20 μg/kg in mice. It is over 300 times more potent than neostigmine.
The 1951 Divizia B was the 12th season of the second tier of the Romanian football league system.
TL-599, also known as SB-8, is an extremely potent carbamate acetylcholinesterase inhibitor.
