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Names | |
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IUPAC name 9-amino-1,2,3,4-tetrahydroacridin-1-ol | |
Identifiers | |
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3D model (JSmol) | |
PubChem CID | |
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Properties | |
C13H14N2O | |
Molar mass | 214.268 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Velnacrine, also known as 1-hydroxytacrine [1] , is an inhibitor of cholinesterase enzymes. It is also a metabolite of tacrine. [2]
Velnacrine is able to inhibit acetylcholinesterase (AChE) [3] , this results in elevated levels of acetylcholine, as AChE is the enzyme that hydrolyzes acetylcholine. [4] It is also able to inhibit butyrylcholinesterase. [5]
Velnacrine, as many other cholinergics, has been described as possibly useful to help manage symptoms of Alzheimer's disease. Some research has described the drug as having benefits over placebo [6] and an acceptable safety profile. [7] However, a review described available data as not proving efficacy and showing evidence of toxicity. [8] Additionally, the FDA voted against recommending approval of velnacrine. [8]