Crotylsarin

Last updated
Crotylsarin
Crotylsarin structure.png
Names
Preferred IUPAC name
(2E)-But-2-en-1-yl methylphosphonofluoridate
Other names
CRS
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
UNII
  • InChI=1S/C5H10FO2P/c1-3-4-5-8-9(2,6)7/h3-4H,5H2,1-2H3/b4-3+
    Key: CSVWTPQEXJLYLO-ONEGZZNKSA-N
  • C/C=C/COP(=O)(C)F
Properties
C5H10FO2P
Molar mass 152.105 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Crotylsarin (CRS) is an extremely toxic organophosphate nerve agent of the G-series. [1] Like other nerve agents, CRS irreversibly inhibits acetylcholinesterase. However, since the inhibited enzyme ages so rapidly, it can't be reactivated by cholinesterase reactivators. [2] [3]

See also

References

  1. ↑ Worek, Franz; Wille, Timo; Koller, Marianne; Thiermann, Horst (27 June 2016). "Toxicology of organophosphorus compounds in view of an increasing terrorist threat". Archives of Toxicology. 90 (9): 2131–2145. Bibcode:2016ArTox..90.2131W. doi:10.1007/s00204-016-1772-1. PMID   27349770. S2CID   15724842.
  2. ↑ Busker, R.W.; Zijlstra, J.J.; van der Wiel, H.J.; Melchers, B.P.C.; van Helden, H.P.M. (January 1991). "Organophosphate poisoning: a method to test therapeutic effects of oxamines other than acetylcholinesterase activation in the rat". Toxicology. 69 (3): 331–344. Bibcode:1991Toxgy..69..331B. doi:10.1016/0300-483x(91)90191-3. PMID   1658986.
  3. ↑ Soukup, O.; Jun, D.; Tobin, G.; Kuca, K. (21 November 2012). "The summary on non-reactivation cholinergic properties of oxime reactivators: the interaction with muscarinic and nicotinic receptors". Archives of Toxicology. 87 (4): 711–719. doi:10.1007/s00204-012-0977-1. PMID   23179755. S2CID   18252681.
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