Croton oil (Crotonis oleum) is an oil prepared from the seeds of Croton tiglium , [1] a tree belonging to the order Euphorbiales and family Euphorbiaceae, and native or cultivated in India and the Malay Archipelago. Small doses taken internally cause diarrhea. [1] Externally, the oil can cause irritation and swelling. Croton oil is used in Phenol-croton oil chemical peels [2] for its caustic exfoliating effects it has on the skin. [3] Used in conjunction with phenol solutions, it results in an intense reaction which leads to initial skin sloughing. Since croton oil is very irritating and painful, it is used in laboratory animals to study how pain works, pain-relieving and anti-inflammatory drugs, and immunology. [4]
Because croton tiglium oil is cocarcinogenic, it has been used in tumor research. [5] Berenblum and Shubik saw croton oil as a “promoting” agent: [6] a kind of carcinogen that acted through an inflammatory response. Mice painted only with croton oil hadn’t developed tumors. Croton oil is the source of the chemical compound phorbol. [7] Tumor promotion activity was traced to phorbol esters present in croton oil. [8] Pure phorbol 12-myristate 13-acetate which is found in croton oil is widely used in laboratory research to induce tumor development.
During World War II, the United States Navy added a small amount of croton oil to the neutral grain spirits which powered torpedoes. The oil was intended to prevent sailors from drinking the alcohol fuel. Sailors devised crude stills to separate the alcohol from the croton oil, as alcohol evaporates at a lower temperature than croton oil. [9]
Norwegian partisans among workers at a factory, ordered by the Quisling government to turn over a catch of sardines to the Nazi German government for shipment to Saint-Nazaire (a U-boat base of operations) arranged with the British for a large shipment of croton oil to covertly poison the sardines, whose fishy taste was expected to conceal the tampering. [10]
In "The Bulletin" (9 Dowry Square, Hot Wells, May 29, 1845) by the Reverend Richard Harris Barham, a medically inspired poem to relieve the anxiety of a very dear friend, and written a month before Barham's death on June 17, 1845, the attending doctor to his patient advises amongst other treatments for a sore throat that is producing barely a sound: "... Please put out your tongue again! / Now the blister! / Ay, the blister! / Let your son, or else his sister, / Warm it well, then clap it here, sir, / All across from ear to ear, sir; / That suffices, / When it rises, / Snip it, sir, and then your throat on / Rub a little oil of Croton: / Never mind a little pain! / Please put out your tongue again! ..." The patient was Barham, who had accidentally swallowed a piece of pear core that got into his windpipe on October 28, 1844. Despite the "professional" advice and the very painful and "highest quality" treatments of the time being given freely to him by Doctors Roberts and Scott, and the eminent surgeon Mr. Coulson, for "violent vomiting", "inflamed throat", and then catching "a cold" in April 1845, Barham died.
"Medicinal" croton oil was supplied in the California Genocide to dying Indian groups. [11]
In Thomas Wolfe's 1929 novel Look Homeward Angel , 18-year-old Steve Gant and a friend sneak into neighbors' barn. Steve and his friend find in the barn a liquor bottle the husband hid from the wife and drink the entire bottle. For revenge, the husband refills the bottle with croton oil. When Steve and his friend return to the barn and find the bottle refilled, they drink from it. This time they get very sick.
In John Steinbeck's novel East of Eden , published in 1952, Kate uses it to murder Faye and inherit her whorehouse. Faye is poisoned with a combination of first strychnine (unsuccessfully) and then two drops of croton oil, on a salad of home-canned beans, mimicking accidental botulism poisoning. To allay suspicion, Kate also poisons herself with cáscara sagrada which gives the same cathartic symptoms, but to a non-fatal degree. [12] [13] Steinbeck also alludes to croton oil in In Dubious Battle , chapter 7. [14]
In the movie They Rode West , released in 1954 and starring Robert Francis, an Army post's previous physician was widely disliked because he frequently prescribed croton oil for the troops.
In the 1966 movie El Dorado starring John Wayne, cayenne pepper, hot mustard, ipecac, asafoetida, croton oil, and gunpowder are the ingredients in an emetic administered to the drunken sheriff J. P. Harrah (Robert Mitchum) to sober him up and prevent him from drinking for the foreseeable future. Arthur Hunnicutt's character Bull expresses great surprise that the extract's use will be risked.
In Bernard Cornwell's 1994 historical fiction Copperhead, the second book of The Starbuck Chronicles, Nate Starbuck is force fed croton oil over a number of days whilst being interrogated by the Confederate authorities after he was accused of being involved in the attempted passing of sensitive military information to the Union. [15]
Mouthwash, mouth rinse, oral rinse, or mouth bath is a liquid which is held in the mouth passively or swirled around the mouth by contraction of the perioral muscles and/or movement of the head, and may be gargled, where the head is tilted back and the liquid bubbled at the back of the mouth.
Phenol, or Benzenol, is an aromatic organic compound with the molecular formula C6H5OH. It is a white crystalline solid that is volatile. The molecule consists of a phenyl group bonded to a hydroxy group. Mildly acidic, it requires careful handling because it can cause chemical burns.
A poison is any chemical substance that is harmful or lethal to living organisms. The term is used in a wide range of scientific fields and industries, where it is often specifically defined. It may also be applied colloquially or figuratively, with a broad sense.
The cashew tree is a tropical evergreen tree native to South America in the genus Anacardium that produces the cashew seed and the cashew apple accessory fruit. The tree can grow as tall as 14 metres, but the dwarf cultivars, growing up to 6 m (20 ft), prove more profitable, with earlier maturity and greater yields. The cashew seed is commonly considered a snack nut eaten on its own, used in recipes, or processed into cashew cheese or cashew butter. Like the tree, the nut is often simply called a cashew. Cashew allergies are triggered by the proteins found in tree nuts, and cooking often does not remove or change these proteins.
Creosote is a category of carbonaceous chemicals formed by the distillation of various tars and pyrolysis of plant-derived material, such as wood, or fossil fuel. They are typically used as preservatives or antiseptics.
Cresols are a group of aromatic organic compounds. They are widely-occurring phenols which may be either natural or manufactured. They are also categorized as methyl phenols. Cresols commonly occur as either solids or liquids because their melting points are generally close to room temperature. Like other types of phenols, they are slowly oxidized by exposure to air, and the resulting impurities often give the samples a yellow to brownish red tint. Cresols have an odor characteristic to that of other simple phenols, reminiscent to some of a "coal tar" smell. The name "cresol" is an adduct of phenol and their traditional source, creosote.
Rubbing alcohol is either an isopropyl alcohol or an ethanol-based liquid, with isopropyl alcohol products being the most widely available. The comparable British Pharmacopoeia (BP) is surgical spirit. Rubbing alcohol is denatured and undrinkable even if it is ethanol-based, due to the bitterants added.
A disinfectant is a chemical substance or compound used to inactivate or destroy microorganisms on inert surfaces. Disinfection does not necessarily kill all microorganisms, especially resistant bacterial spores; it is less effective than sterilization, which is an extreme physical or chemical process that kills all types of life. Disinfectants are generally distinguished from other antimicrobial agents such as antibiotics, which destroy microorganisms within the body, and antiseptics, which destroy microorganisms on living tissue. Disinfectants are also different from biocides—the latter are intended to destroy all forms of life, not just microorganisms. Disinfectants work by destroying the cell wall of microbes or interfering with their metabolism. It is also a form of decontamination, and can be defined as the process whereby physical or chemical methods are used to reduce the amount of pathogenic microorganisms on a surface.
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer (in which it is used as a flavoring), but often associatively called "minty", as it is an ingredient in mint candies. It is produced by many species of plants, particularly wintergreens. It is also produced synthetically, used as a fragrance and as a flavoring agent.
12-O-Tetradecanoylphorbol-13-acetate (TPA), also commonly known as tetradecanoylphorbol acetate, tetradecanoyl phorbol acetate, and phorbol 12-myristate 13-acetate (PMA) is a diester of phorbol. It is a potent tumor promoter often employed in biomedical research to activate the signal transduction enzyme protein kinase C (PKC). The effects of TPA on PKC result from its similarity to one of the natural activators of classic PKC isoforms, diacylglycerol. TPA is a small molecule drug.
The health effects of wine are mainly determined by its active ingredient – alcohol. Preliminary studies found that drinking small quantities of wine, particularly of red wine, may be associated with a decreased risk of cardiovascular diseases, cognitive decline, stroke, diabetes mellitus, metabolic syndrome, and early death. Other studies found no such effects.
Guaiacol is an organic compound with the formula C6H4(OH)(OCH3). It is a phenolic compound containing a methoxy functional group. Guaiacol appears as a viscous colorless oil, although aged or impure samples are often yellowish. It occurs widely in nature and is a common product of the pyrolysis of wood.
Neurolysis is the application of physical or chemical agents to a nerve in order to cause a temporary degeneration of targeted nerve fibers. When the nerve fibers degenerate, it causes an interruption in the transmission of nerve signals. In the medical field, this is most commonly and advantageously used to alleviate pain in cancer patients.
Phorbol is a natural, plant-derived organic compound. It is a member of the tigliane family of diterpenes. Phorbol was first isolated in 1934 as the hydrolysis product of croton oil, which is derived from the seeds of the purging croton, Croton tiglium. The structure of phorbol was determined in 1967. Various esters of phorbol have important biological properties, the most notable of which is the capacity to act as tumor promoters through activation of protein kinase C. They mimic diacylglycerols, glycerol derivatives in which two hydroxyl groups have reacted with fatty acids to form esters. The most common and potent phorbol ester is 12-O-tetradecanoylphorbol-13-acetate (TPA), also called phorbol-12-myristate-13-acetate (PMA), which is used as a biomedical research tool in contexts such as models of carcinogenesis.
A chemical peel is a technique used to improve and smooth the texture of the skin. Facial skin is mostly treated, and scarring can be improved. Chemical peels are intended to remove the outermost layers of the skin. To accomplish this task, the chosen peel solution induces a controlled injury to the skin. Resulting wound healing processes begin to regenerate new tissues. The dead skin eventually peels off. The regenerated skin is usually smoother and less wrinkled than the old skin. Some types of chemical peels can be purchased and administered without a medical license; however, people are advised to seek professional help from a dermatologist or plastic surgeon on a specific type of chemical peel before a procedure is performed.
Absinthe is an anise-flavored spirit derived from several plants, including the flowers and leaves of Artemisia absinthium, together with green anise, sweet fennel, and other medicinal and culinary herbs. Historically described as a highly alcoholic spirit, it is 45–74% ABV or 90–148 proof in the US. Absinthe traditionally has a natural green color but may also be colorless. It is commonly referred to in historical literature as la fée verte. It is sometimes mistakenly referred to as a liqueur, but is not traditionally bottled with added sugar, so is classified as a spirit. Absinthe is traditionally bottled at a high level of alcohol by volume, but it is normally diluted with water before being consumed.
Aplysiatoxin is a cyanotoxin produced by certain cyanobacteria species. It is used as a defensive secretion to protect these cyanobacteria from predation by fish, being a potent irritant and carcinogen, by acting as a powerful activator of protein kinase C. While this action has a tumour-promoting effect, protein kinase C activation can be medically beneficial for some other applications, and synthetic analogues of aplysiatoxin have been researched for anti-cancer effects.
Phorbol 12,13-dibutyrate (PDBu) is a phorbol ester which is one of the constituents of croton oil. As an activator of protein kinase C, it is a weak tumor promoter compared to 12-O-tetradecanoylphorbol-13-acetate.
Syringic acid is a naturally occurring phenolic compound and dimethoxybenzene that is commonly found as a plant metabolite.
Methanol toxicity is poisoning from methanol, characteristically via ingestion. Symptoms may include a decreased level of consciousness, poor or no coordination, vomiting, abdominal pain, and a specific smell on the breath. Decreased vision may start as early as twelve hours after exposure. Long-term outcomes may include blindness and kidney failure. Blindness may occur after drinking as little as 10 mL; death may occur after drinking quantities over 15 mL.