Lewisite

Last updated
Lewisite [1]
Lewisite.svg
Lewisite-calculated-by-MP2-3D-balls.png
Lewisite-calculated-by-MP2-3D-SF.png
Names
Preferred IUPAC name
[(E)-2-Chloroethen-1-yl]arsonous dichloride
Other names
Chlorovinylarsine dichloride
2-Chloroethenyldichloroarsine
(E)-2-Chlorovinylarsonous dichloride
(E)-2-Chlorovinyldichloroarsine
Dichloro((E)-2-chlorovinyl)arsine
Identifiers
3D model (JSmol)
ChemSpider
MeSH lewisite
PubChem CID
UNII
UN number 2810
  • InChI=1S/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+ Yes check.svgY
    Key: GIKLTQKNOXNBNY-OWOJBTEDSA-N Yes check.svgY
  • InChI=1/C2H2AsCl3/c4-2-1-3(5)6/h1-2H/b2-1+
    Key: GIKLTQKNOXNBNY-OWOJBTEDBF
  • Cl[As](Cl)\C=C\Cl
Properties
C2H2AsCl3
Molar mass 207.32 g/mol
Density 1.89 g/cm3
Melting point −18 °C (0 °F; 255 K)
Boiling point 190 °C (374 °F; 463 K)
Reacts with water
Solubility Ethers, hydrocarbons, THF
Vapor pressure 0.58 mmHg (25 °C)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Flammable, highly toxic, corrosive, vesicant
NFPA 704 (fire diamond)
NFPA 704.svgHealth 4: Very short exposure could cause death or major residual injury. E.g. VX gasFlammability 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g. canola oilInstability 1: Normally stable, but can become unstable at elevated temperatures and pressures. E.g. calciumSpecial hazards (white): no code
4
1
1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Yes check.svgY  verify  (what is  Yes check.svgYX mark.svgN ?)

Lewisite (L) (A-243) is an organoarsenic compound. It was once manufactured in the U.S., Japan, Germany [2] and the Soviet Union [3] for use as a chemical weapon, acting as a vesicant (blister agent) and lung irritant. Although the substance is colorless and odorless in its pure form, impure samples of lewisite are a yellow, brown, violet-black, green, or amber oily liquid with a distinctive odor that has been described as similar to geraniums. [4] [5] [6]

Contents

Lewisite is named after the US chemist and soldier Winford Lee Lewis (1878–1943). Apart from its use as a weapon of war, the compound is useless; a chemist from the United States Army's chemical warfare laboratories said that "no one has ever found any use for the compound". [7]

Chemical reactions

The compound is prepared by the addition of arsenic trichloride to acetylene in the presence of a suitable catalyst:

AsCl3 + C2H2 → ClCHCHAsCl2 (Lewisite)

This chemical process can occur a second or third time, giving lewisite 2 and lewisite 3 as byproducts. [8]

Lewisite, like other arsenous chlorides, hydrolyses in water to form hydrochloric acid and chlorovinylarsenous oxide (a less-powerful blister agent): [5]

ClCHCHAsCl2 + 2 H2O → ClCHCHAs(OH)2 + 2 HCl

This reaction is accelerated in alkaline solutions, and forms acetylene and trisodium arsenate. [5]

Lewisite reacts with metals to form hydrogen gas. It is combustible, but difficult to ignite. [5]

Applications

Apart from deliberately injuring and killing people, lewisite has no commercial, industrial, or scientific applications. [7] In a 1959 paper regarding the development of a batch process for lewisite synthesis, Gordon Jarman of the United States Army Chemical Warfare Laboratories said:

The manufacture can be one of the easiest and most economical in the metal-organic field, and it is regretted that no one has ever found any use for the compound. It is a pity to waste such a neat process. [7]

While the compound itself has no useful application, a 1993 report from the US Defense Nuclear Agency detailed attempts by Russian chemists in "exploring processes for the conversion of these agents to marketable products", including the extraction of high-purity arsenic for use in semiconductor doping (as gallium arsenide). The report, however, concluded that "the engineering and scale up of the process to a production level may be prohibitively difficult" and that "unless other metallic impurities which are likely to be found in Lewisite are removed, the high purity required for chip application may require additional steps", noting that worldwide demand for arsenic compounds (already declining at the time) was projected to shrink further, and that the proposed economics of the conversion process did not align with then-current prices for gallium arsenide. [9]

Mechanism of action

Lewisite is a suicide inhibitor of the E3 component of pyruvate dehydrogenase. As an efficient method to produce ATP, pyruvate dehydrogenase is involved in the conversion of pyruvate to acetyl-CoA. The latter subsequently enters the TCA cycle. Peripheral nervous system pathology usually arises from Lewisite exposure as the nervous system essentially relies on glucose as its only catabolic fuel. [10]

Lewisite (top row) and mustard gas test with concentrations from 0.01% to 0.06% TestYperite4030618980 242ab5c81d b.jpg
Lewisite (top row) and mustard gas test with concentrations from 0.01% to 0.06%

It can easily penetrate ordinary clothing and latex rubber gloves. Upon skin contact it causes immediate stinging, burning pain and itching that can last for 24 hours. Within minutes, a rash develops and the agent is absorbed through the skin. Large, fluid-filled blisters (similar to those caused by mustard gas exposure) develop after approximately 12 hours and cause pain for 2–3 days. [4] [5] These are severe chemical burns and begin with small blisters in the red areas of the skin within 2–3 hours and grow worse, encompassing the entire red area, for the ensuing 12–18 hours after initial exposure. Liquid lewisite has faster effects than lewisite vapor. [5] Sufficient absorption can cause deadly liver necrosis.

Those exposed to lewisite can develop refractory hypotension (low blood pressure) known as Lewisite shock, with some features of arsenic toxicity. [11] Lewisite damages capillaries, which then become leaky, reducing blood volume required to maintain blood pressure, a condition called hypovolemia. When the blood pressure is low, the kidneys may not receive enough oxygen and can be damaged. [5]

Inhalation, the most common route of exposure, causes burning pain and irritation throughout the respiratory tract, nosebleed (epistaxis), laryngitis, sneezing, coughing, vomiting, difficult breathing (dyspnea), and in severe cases of exposure, can cause fatal pulmonary edema, pneumonitis, or respiratory failure. Ingestion results in severe pain, nausea, vomiting, and tissue damage. [4] [5] The results of eye exposure can range from stinging, burning pain and strong irritation to blistering and scarring of the cornea, along with blepharospasm, lacrimation, and edema of the eyelids and periorbital area. The eyes can swell shut, which can keep the eyes safe from further exposure. The most severe consequences of eye exposure to lewisite are globe perforation and blindness. [5] Generalised symptoms also include restlessness, weakness, hypothermia and low blood pressure.

It is possible that Lewisite is carcinogenic: arsenic is categorized as a respiratory carcinogen by the International Agency for Research on Cancer, though it has not been confirmed that lewisite is a carcinogen. [12]

Lewisite causes damage to the respiratory tract at levels lower than the odor detection threshold. Early tissue damage causes pain. [5]

Hydrolysis leads to chlorovinylarsonous acid, CVAA.

Treatment

British anti-lewisite, also called dimercaprol, is the antidote for lewisite. It can be injected to prevent systemic toxicity, but will not prevent injury to the skin, eyes, or mucous membranes. Chemically, dimercaprol binds to the arsenic in lewisite. It is contraindicated in those with peanut allergies. [5]

Other treatment for lewisite exposure is primarily supportive. First aid of lewisite exposure consists of decontamination and irrigation of any areas that have been exposed. Other measures can be used as necessary, such as airway management, assisted ventilation, and monitoring of vital signs. In an advanced care setting, supportive care can include fluid and electrolyte replacement. Because the tube may injure or perforate the esophagus, gastric lavage is contraindicated. [5]

Long-term effects

From one acute exposure, someone who has inhaled lewisite can develop chronic respiratory disease; eye exposure to lewisite can cause permanent visual impairment or blindness. [5]

Chronic exposure to lewisite can cause arsenic poisoning (due to its arsenic content) and development of a lewisite allergy. It can also cause long-term illnesses or permanent damage to organs, depending on where the exposure has occurred, including conjunctivitis, aversion to light (photophobia), visual impairment, double vision (diplopia), tearing (lacrimation), dry mucous membranes, garlic breath, burning pain in the nose and mouth, toxic encephalopathy, peripheral neuropathy, seizures, nausea, vomiting, chronic obstructive pulmonary disease (COPD), bronchitis, dermatitis, skin ulcers, basal cell carcinoma, and squamous cell carcinoma. [5]

Chemical composition

Lewisite can be a mixture of molecules with a different number of vinylchloride groups on the arsenic chloride: lewisite itself (2-chlorovinylarsonous dichloride), along with bis(2-chlorovinyl)arsinous chloride (lewisite 2) and tris(2-chlorovinyl)arsine (lewisite 3). [13] In addition, there are sometimes isomeric impurities: lewisite itself is mostly trans-2-chlorovinylarsonous dichloride, but the cis stereoisomer and the constitutional isomer (1-chlorovinylarsonous dichloride) may also be present. [14]

Experimental and computational studies both find that the trans-2-chloro isomer is the most stable, and that the carbon–arsenic bond has a conformation in which the lone pair on the arsenic is approximately aligned with the vinyl group. [14]

History

Lewisite identification poster from World War II. "Lewisite, smells like geraniums" (OHA 365) National Museum of Health and Medicine (5405373716).jpg
Lewisite identification poster from World War II.

Lewisite was synthesized in 1904 by Julius Arthur Nieuwland during studies for his PhD. [15] [16] [17] In his thesis, he described a reaction between acetylene and arsenic trichloride, which led to the formation of lewisite. [18] Exposure to the resulting compound made Nieuwland so ill he was hospitalized for several days. [16]

Lewisite is named after the US chemist and soldier Winford Lee Lewis (1878–1943). [19] In 1918, John Griffin, Julius Arthur Nieuwland's thesis advisor, drew Lewis's attention to Nieuwland's thesis at Maloney Hall, a chemical laboratory at The Catholic University of America, Washington D.C. [20] Lewis then attempted to purify the compound through distillation but found that the mixture exploded on heating until it was washed with HCl. [20]

Lewisite was developed into a secret weapon at a facility located in Cleveland, Ohio (The Cleveland Plant) at East 131st Street and Taft Avenue, [19] [21] and given the name "G-34", which had previously been the code for mustard gas, in order to confuse its development with mustard gas. [22] On November 1, 1918, production began at a plant in Willoughby, Ohio. [23] It was not used in World War I, but Britain experimented with it in the 1920s as the "Dew of Death". [24]

After World War I, the US became interested in lewisite because it was not flammable. Up until World War II, it had the military symbol of "M1", after which it was changed to "L". Field trials with lewisite during World War II demonstrated that casualty concentrations were not achievable under high humidity, due to the rate of hydrolysis and the characteristic odor of the chemical, and the formation of tears forced troops to don masks and avoid contaminated areas.[ citation needed ] The United States produced about 20,000 tons of lewisite, keeping it on hand primarily as an antifreeze for mustard gas, or to penetrate protective clothing in special situations.

Lewisite was replaced by the mustard gas variant HT (a 60:40 mixture of sulfur mustard and O-Mustard), and was declared obsolete in the 1950s. Lewisite poisoning can be treated effectively with British anti-lewisite (dimercaprol). Most stockpiles of lewisite were neutralised with bleach and dumped into the Gulf of Mexico. [25] The last remaining U.S. stockpiles at the Deseret Chemical Depot located outside Salt Lake City, Utah were destroyed in January 2012. [26]

Production of quantities greater than 100 grams per year per facility were banned by Schedule 1 of the 1993 Chemical Weapons Convention. When the convention entered force in 1997, the parties declared world-wide stockpiles of 6,747 tonnes. By the end of 2015, 98% of the declared stockpiles had been destroyed. [27]

In 2001, lewisite was found in a World War I weapons dump in Washington, D.C. [28]

In July 2023 a spokesman of the Armed Forces of Ukraine claimed that during the battle of Bakhmut a Russian artillery attack against Ukrainian forces had included lewisite, causing symptoms of nausea, vomiting and in some cases loss of consciousness. [29] However, no information from any sample analysis were published.

Controversy over Japanese deposits of lewisite in China

In mid-2006, China and Japan were negotiating disposal of lewisite stockpile in northeastern China, left by the Japanese military during World War II. People had died over the preceding twenty years from accidental exposure to these stockpiles. [30]

See also

Related Research Articles

<span class="mw-page-title-main">Mustard gas</span> Compound used in chemical warfare

Mustard gas or sulfur mustard is any of the several chemical compounds that contain the chemical structure S(CH2CH2Cl)2. In the wider sense, compounds with the substituent S(CH2CH2X)2 and N(CH2CH2X)3 are known as sulfur mustards and nitrogen mustards, respectively, where X = Cl or Br. Such compounds are potent alkylating agents, which can interfere with several biological processes. Also known as mustard agents, this family of compounds are infamous cytotoxins and blister agents with a long history of use as chemical weapons. The name mustard gas is technically incorrect: the substances, when dispersed, are often not gases but a fine mist of liquid droplets. Sulfur mustards are viscous liquids at room temperature and have an odor resembling mustard plants, garlic, or horseradish, hence the name. When pure, they are colorless, but when used in impure forms, such as in warfare, they are usually yellow-brown. Mustard gases form blisters on exposed skin and in the lungs, often resulting in prolonged illness ending in death. The typical mustard gas is the organosulfur compound bis(2-chloroethyl) sulfide.

<span class="mw-page-title-main">Chemical warfare</span> Using poison gas or other toxins in war

Chemical warfare (CW) involves using the toxic properties of chemical substances as weapons. This type of warfare is distinct from nuclear warfare, biological warfare and radiological warfare, which together make up CBRN, the military acronym for chemical, biological, radiological, and nuclear, all of which are considered "weapons of mass destruction" (WMDs), a term that contrasts with conventional weapons.

<span class="mw-page-title-main">Sarin</span> Chemical compound and chemical warfare nerve agent

Sarin is an extremely toxic organophosphorus compound. A colourless, odourless liquid, it is used as a chemical weapon due to its extreme potency as a nerve agent. Exposure can be lethal even at very low concentrations, where death can occur within one to ten minutes after direct inhalation of a lethal dose, due to suffocation from respiratory paralysis, unless antidotes are quickly administered. People who absorb a non-lethal dose and do not receive immediate medical treatment may suffer permanent neurological damage.

<span class="mw-page-title-main">Tabun (nerve agent)</span> Chemical compound

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<span class="mw-page-title-main">Chemical weapons in World War I</span>

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<span class="mw-page-title-main">Blister agent</span> Chemicals that result in blistering and skin irritation and damaging

A blister agent, is a chemical compound that causes severe skin, eye and mucosal pain and irritation. They are named for their ability to cause severe chemical burns, resulting in painful water blisters on the bodies of those affected. Although the term is often used in connection with large-scale burns caused by chemical spills or chemical warfare agents, some naturally occurring substances such as cantharidin are also blister-producing agents (vesicants). Furanocoumarin, another naturally occurring substance, causes vesicant-like effects indirectly, for example, by increasing skin photosensitivity greatly. Vesicants have medical uses including wart removal but can be dangerous if even small amounts are ingested.

<span class="mw-page-title-main">Chemical burn</span> Medical condition

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<span class="mw-page-title-main">Dimercaprol</span> Chemical compound

Dimercaprol, also called British anti-Lewisite (BAL), is a medication used to treat acute poisoning by arsenic, mercury, gold, and lead. It may also be used for antimony, thallium, or bismuth poisoning, although the evidence for those uses is not very strong. It is given by injection into a muscle.

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<span class="mw-page-title-main">Methyldichloroarsine</span> Chemical compound

Methyldichloroarsine, sometimes abbreviated "MD" and also known as methyl Dick, is an organoarsenic compound with the formula CH3AsCl2. This colourless volatile liquid is a highly toxic vesicant that has been used in chemical warfare.

<span class="mw-page-title-main">Phenyldichloroarsine</span> Chemical compound

Phenyldichloroarsine, also known by its wartime name phenyl Dick and its NATO abbreviation PD, is an organic arsenical vesicant and vomiting agent developed by Germany and France for use as a chemical warfare agent during World War I. The agent is known by multiple synonyms and is technically classified as a vesicant, or blister agent.

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<span class="mw-page-title-main">Chemical weapon</span> Device that uses chemicals to kill or harm individuals

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<span class="mw-page-title-main">Lewisite 2</span> Chemical compound

Lewisite 2(L-2) is an organoarsenic chemical weapon with the formula AsCl(CH=CHCl)2. It is similar to lewisite 1 and lewisite 3 and was first synthesized in 1904 by Julius Arthur Nieuwland. It is usually found as a mixture of 2-chlorovinylarsonous dichloride (lewisite 1) as well as bis(2-chloroethenyl) arsinous chloride (lewisite 2) and tris(2-chlorovinyl)arsine (lewisite 3). Pure lewisite 1 is an oily, colorless liquid, however, the impure mixture can appear amber to black with an odor distinct to geraniums.

<span class="mw-page-title-main">Lewisite 3</span> Chemical compound

Lewisite 3(L-3) is an organoarsenic chemical weapon like lewisite 1 and lewisite 2 first synthesized in 1904 by Julius Arthur Nieuwland. It is usually found as a mixture of 2-chlorovinylarsonous dichloride as well as bis(2-chloroethenyl) arsinous chloride and tris(2-chlorovinyl)arsine. Pure lewisite 1 is an oily, colorless liquid, however, the impure mixture can appear amber to black with an odor distinct to geraniums.

References

  1. ↑ Lewisite I – Compound Summary, PubChem.
  2. ↑ Mitchell, Jon (27 July 2013). "A drop in the ocean: the sea-dumping of chemical weapons in Okinawa" – via Japan Times Online.
  3. ↑ "Russia Completes Destruction of First 10 Tons of Lewisite – Analysis – NTI". www.nti.org.
  4. 1 2 3 U.S. National Research Council, Committee on Review and Evaluation of the Army Non-Stockpile Chemical Materiel Disposal Program (1999). Disposal of Chemical Agent Identification Sets. National Academies Press. p. 16. ISBN   0-309-06879-7.
  5. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 "CDC – The Emergency Response Safety and Health Database: Blister Agent: Lewsite (L) – NIOSH". www.cdc.gov. Retrieved 2016-01-14.
  6. ↑ Goldman, Max; Dacre, Jack C. (February 14, 1989). Ware, George W. (ed.). "Reviews of Environmental Contamination and Toxicology: Continuation of Residue Reviews". Reviews of Environmental Contamination and Toxicology. 110. Springer: 75–115. doi:10.1007/978-1-4684-7092-5_2. PMID   2692088 – via Springer Link.
  7. 1 2 3 Jarman, Gordon N. (January 1, 1959). "Chemical Corps Experience in the Manufacture of Lewisite". Metal-Organic Compounds. Advances in Chemistry. Vol. 23. American Chemical Society. pp. 328–337. doi:10.1021/ba-1959-0023.ch031. ISBN   978-0-8412-0024-1.
  8. ↑ Chemistry of Sulfur Mustard and Lewisite https://www.ncbi.nlm.nih.gov/books/NBK236079/
  9. ↑ Bosco, Salvatore (May 1993). "Commercial Products from Demilitarization Operations" (PDF). Defense Nuclear Agency.
  10. ↑ Berg, J.; Tymoczko, J. L.; Stryer, L. (2007). Biochemistry (6th ed.). New York: Freeman. pp. 494–495. ISBN   978-0-7167-8724-2.
  11. ↑ Chauhan, S.; Chauhan, S.; D’Cruz, R.; Faruqi, S.; Singh, K. K.; Varma, S.; Singh, M.; Karthik, V. Chemical warfare agents. Environ. Toxicol. Pharmacol. 2008, 26, 113–122
  12. ↑ Doi, M.; Hattori, N.; Yokoyama, A.; Onari, Y.; Kanehara, M.; Masuda, K.; Tonda, T.; Ohtaki, M.; Kohno, N. Effect of Mustard Gas Exposure on Incidence of Lung Cancer: A Longitudinal Study. American Journal of Epidemiology 2011, 173, 659–666.
  13. ↑ McNutt, Patrick M.; Tracey L., Hamilton (2015). "Ocular toxicity of chemical warfare agents". Handbook of Toxicology of Chemical Warfare Agents. Academic Press. pp. 535–555.
  14. 1 2 Urban, Joseph J.; von Tersch, Robert L. (1999). "Conformational analysis of the isomers of lewisite". J. Phys. Org. Chem. 12 (2): 95–102. doi: 10.1002/(SICI)1099-1395(199902)12:2<95::AID-POC91>3.0.CO;2-V .
  15. ↑ Julius Arthur Nieuwland (1904) Some Reactions of Acetylene , Ph.D. thesis, University of Notre Dame (Notre Dame, Indiana).
  16. 1 2 Vilensky, J. A. (2005). Dew of Death – The Story of Lewisite, America's World War I Weapon of Mass Destruction. Indiana University Press. p. 4. ISBN   0253346126.
  17. ↑ Vilensky, J. A.; Redman, K. (2003). "British Anti-Lewisite (Dimercaprol): An Amazing History". Annals of Emergency Medicine. 41 (3): 378–383. doi:10.1067/mem.2003.72. PMID   12605205.
  18. ↑ Vilensky, J. "Father Nieuwland and the 'Dew of Death'".
  19. 1 2 "Deadliest Poison Discovered By An American". Early County News. May 29, 1919. p. 7. Retrieved July 30, 2020.
  20. 1 2 Vilensky, J. A. (2005). Dew of Death – The Story of Lewisite, America's World War I Weapon of Mass Destruction. Indiana University Press. pp. 21–23. ISBN   0253346126.
  21. ↑ "Upton native's role was the best defense; WWI masks thwarted". Archived from the original on December 18, 2007.
  22. ↑ Joel A. Vilensky, Dew of Death: The Story of Lewisite, America's World War I Weapon of Mass Destruction (Bloomington, Indiana: Indiana University Press, 2005), page 36.
  23. ↑ Vilensky, J. A. (2005). Dew of Death – The Story of Lewisite, America's World War I Weapon of Mass Destruction. Indiana University Press. p. 50. ISBN   0253346126.
  24. ↑ Tabangcura, D. Jr.; Daubert, G. P. "British anti-Lewisite Development". Molecule of the Month. University of Bristol School of Chemistry.
  25. ↑ Code Red – Weapons of Mass Destruction Online Resources; – Blister Agents
  26. ↑ Moulton, Kristen (2012-01-18). "Commander: World is safer with chemical stockpile gone". The Salt Lake Tribune. Retrieved 25 January 2024.
  27. ↑ Organisation for the Prohibition of Chemical Weapons (30 November 2016). "Annex 3". Report of the OPCW on the Implementation of the Convention on the Prohibition of the Development, Production, Stockpiling and Use of Chemical Weapons and on Their Destruction in 2015 (Report). p. 42. Retrieved 8 March 2017.
  28. ↑ Tucker, J. B. (2001). "Chemical weapons: Buried in the backyard" (PDF). Bulletin of the Atomic Scientists. 57 (5): 51–56. doi:10.2968/057005014.
  29. ↑ Brown, Steve; Korshak, Stefan (2023-07-05). "Russia Using Chemical Weapon During Bakhmut Artillery Bombardments, Ukrainian Official Claims". kyivpost.com . Retrieved 2023-07-05.
  30. ↑ "Abandoned Chemical Weapons (ACW) in China" (PDF). Archived from the original (PDF) on March 5, 2012.
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