Incapacitating agent

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Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness. [1]

Contents

Lethal agents are primarily intended to kill, but incapacitating agents can also kill if administered in a potent enough dose, or in certain scenarios.

The term "incapacitation," when used in a general sense, is not equivalent to the term "disability" as used in occupational medicine and denotes the inability to perform a task because of a quantifiable physical or mental impairment. In this sense, any of the chemical warfare agents may incapacitate a victim; however, by the military definition of this type of agent, incapacitation refers to impairments that are temporary and nonlethal. Thus, riot-control agents are incapacitating because they cause temporary loss of vision due to blepharospasm, but they are not considered military incapacitants because the loss of vision does not last long. Although incapacitation may result from physiological changes such as mucous membrane irritation, diarrhea, or hyperthermia, the term "incapacitating agent" as militarily defined refers to a compound that produces temporary and nonlethal impairment of military performance by virtue of its psychobehavioral or CNS effects.

In biological warfare, a distinction is also made between bio-agents as Lethal Agents (e.g., Bacillus anthracis , Francisella tularensis , Botulinum toxin) or Incapacitating Agents (e.g., Brucella suis , Coxiella burnetii , Venezuelan equine encephalitis virus, Staphylococcal enterotoxin B). [2]

History

Early uses

The use of chemicals to induce altered states of mind in an adversary dates back to antiquity and includes the use of plants of the nightshade family (Solanaceae), such as the thornapple (Datura stramonium), that contain various combinations of anticholinergic alkaloids. The use of nonlethal chemicals to render an enemy force incapable of fighting dates back to at least 600 B.C. when Solon's soldiers threw hellebore roots into streams supplying water to enemy troops, who then developed diarrhea. [3] In 184 B.C., Hannibal's army used belladonna plants to induce disorientation, [4] [5] and the Bishop of Münster in A.D. 1672 attempted to use belladonna-containing grenades in an assault on the city of Groningen. [6]

In 1881, members of a French railway surveying expedition crossing Tuareg territory in North Africa ate dried dates that tribesmen had apparently deliberately contaminated with Egyptian henbane ( Hyoscyamus muticus , or H. falezlez), to devastating effect. [7] In 1908, 200 French soldiers in Hanoi became delirious and experienced hallucinations after being poisoned with a related plant. More recently, accusations of Soviet use of incapacitating agents internally and in Afghanistan were never substantiated.

The 20th century

Following World War II, the United States military investigated a wide range of possible nonlethal, psychobehavioral, chemical incapacitating agents to include psychedelic indoles such as lysergic acid diethylamide (LSD-25) and the tetrahydrocannabinol derivative DMHP, certain tranquilizers, as well as several glycolate anticholinergics. One of the anticholinergic compounds, 3-quinuclidinyl benzilate, was assigned the NATO code "BZ" and was weaponized beginning in the 1960s for possible battlefield use. (Although BZ figured prominently in the plot of the 1990 movie, Jacob's Ladder , as the compound responsible for hallucinations and violent deaths in a fictitious American battalion in Vietnam, this agent never saw operational use.) Destruction of American stockpiles of BZ began in 1988 and is now complete.

US survey and testing programs

By 1958 a search of the Tropics for venomous animal species in order to isolate and synthesize their toxins was prioritized. For example, snake venoms were studied and The College of Medical Evangelists was under contract to isolate puffer fish poison. The New England Institute for Medical Research and Fort Detrick were studying the properties and biological activity of the Botulinum toxin molecule. The U.S. Army Chemical Warfare Laboratories were isolating shellfish toxin and trying to obtain its structure. [8]

A Central Intelligence Agency Project Artichoke document reads: "Not all viruses have to be lethal ... the objective includes those that act as short-term and long-term incapacitants." [9] One of the most urgent of Chemical Corps projects in the period 1960 to 1961 was the effort to achieve a standard chemical incapacitating agent. For several years attention had been fixed on the military potentialities of the psychochemicals of various types. Research on new agents tended to concentrate on viral and rickettsial diseases. A whole range of exotic virus diseases prevalent in tropical areas came within the screening program in 1960-61, with major effort directed at increased first hand knowledge of so-called arboviruses (i.e. arthropod borne viruses). The importance of epidemiological studies in connection with this area of endeavor was being emphasized.[ citation needed ] Pine Bluff Arsenal was a rickittsiae and virus production center and biological agents against wheat and rice fields were tested in several locations the southern U.S. as well as in Okinawa. [10]

The concept of "humane warfare" with widespread use of incapacitating or deliriant drugs such as LSD or Agent BZ to stun an enemy, capture them alive, or separate friend from foe had been available in locations such as Berlin since the 1950s, an initial focus of US CBW development was the offensive use of diseases, drugs, and substances that could completely incapacitate an enemy for several days with some lesser possibility of death using a variety of chemical, biological, radiological, or toxin agents. [11] The US Army Assistant Chief of Staff for Intelligence (ACSI) authorized operational field testing of LSD in interrogations in the early 1960s. The first field tests were conducted in Europe by an Army Special Purpose Team (SPT) during May to August 1961 in tests known as Project THIRD CHANCE. The second series of field tests, Project DERBY HAT, were conducted by an Army Special Purpose Team in the Far East during August to November 1962. [12]

A study of possible uses of migratory birds in germ warfare was funded through Camp Detrick for years using the Smithsonian as a cover. Government documents have linked the Smithsonian to the CIA's mind control program known as MKULTRA. The CIA were interested in bird migration patterns for CBW research under MKULTRA where, a Subproject 139 designated "Bird Disease Studies" at Penn State. An agents purchase of a copy of the book Birds of Britain, Europe, is recorded as part of what was described in a financial accounting of the MKULTRA program as a continuous project on bird survey in special areas. [13] Sampling of native migratory organisms with a focus on birds provided to researchers the natural habitat of disease causing fungus, viruses, and bacteria as well as the established (or potential) vectors for them. The sampling also provided exotic tropical viruses and toxins from the various organisms collected on both land and sea. The studies, including the Pacific Ocean Biological Survey Program (POBSP) were conducted by the Smithsonian Institution and Project SHAD crews on Pacific islands and atolls. The "bird cruises" were subsequently found to be a U.S. Army cover for the prelude to chemical, biological, and entomological warfare experiments related to Deseret Test Center, Project 112, and Project SHAD. [14] [15] [16]

A U.S. War Departments report notes that "in addition to the results of human experimentation much data is available from the Japanese experiments on animals and food crops." [17] German researchers have found that records of the Entomology Institute at the Dachau concentration camp show that under orders of Schutzstaffel (SS) leader Heinrich Himmler, the Nazis began studying mosquitoes as an offensive biological warfare vector against humans in 1942. It was generally thought by historians that the Nazis only intended ever to use biological weapons defensively. [18]

Project 112 included objectives such as “the feasibility of an offshore release of Aedes aegypti mosquitoes as a vector for infectious diseases,” and “the feasibility of a biological attack against an island complex.” [19] "The feasibility of area coverage with adedes aegypti mosquitoes was based on the Avon Park, Florida mosquito trials." [20] Several CIA documents, and a 1975 Congressional committee, revealed that several locations in Florida, as well as Avon Park, hosted experiments with mosquito-borne viruses and other biological substances. Formerly top-secret documents related to the CIA's Project MKNAOMI prove that the mosquitoes used in Avon Park were the Aedes aegypti type. "A 1978 Pentagon publication, entitled Biological Warfare: Secret Testing & Volunteers, reveals that the Army's Chemical Corps and Special Operations and Projects Divisions at Fort Detrick conducted 'tests' similar to the Avon Park experiments but the bulk of the documentation concerning this highly classified and covert work is still held secret by the Pentagon." [9]

Sleeping gas

Sleeping gas is an oneirogenic general anaesthetic that is used to put subjects into a state in which they are not conscious of what is happening around them. Most sleeping gases have undesirable side effects, or are effective at doses that approach toxicity.

It is primarily used for major surgeries and to render non-dangerous animals unconscious for research purposes.

Examples of modern volatile anaesthetics that may be considered sleeping gases are BZ, [21] halothane vapour (Fluothane), [22] methyl propyl ether (Neothyl), methoxyflurane (Penthrane), [23] and the undisclosed fentanyl derivative delivery system used by the FSB in the Moscow theater hostage crisis. [24]

Picture of a sleeping gas alarm on sale in Finland. Sleeping gas alarm retail package.jpg
Picture of a sleeping gas alarm on sale in Finland.

Side effects

Possible side effects might not prevent use of sleeping gas by criminals willing to murder, or carefully control the dose on a single already sleepy individual. There are reports of thieves spraying sleeping gases on campers, [25] or in train compartments in some parts of Europe. [26] Alarms are sold to detect such attacks and alert the victim. [25]

Moscow theatre siege

There is one documented case of incapacitating agents being used in recent years. In 2002, Chechen terrorists took a large number of hostages in the Moscow theatre siege, and threatened to blow up the entire theatre if any attempt was made to break the siege. An incapacitating agent was used to disable the terrorists whilst the theatre was stormed by special forces. However, the incapacitating agent, unknown at that time, caused many of the hostages to die. The terrorists were rendered unconscious, but roughly 15% of the 800 people exposed were killed by the gas. [27] The situation was not helped by the fact that the authorities kept the nature of the incapacitating agent secret from doctors trying to treat its victims. At the time, the gas was reported to be an unknown incapacitating agent called "Kolokol-1". The Russian Health Minister Yuri Shevchenko later stated that the incapacitating agent used was a fentanyl derivative.

Scientists at Britain's chemical and biological defense labs at Porton Down analyzed residue from the clothing of three hostages and the urine of one hostage rescued during the Moscow theater hostage crisis and found two chemical derivatives of fentanyl, remifentanil and carfentanil. [28]

Bolivian rapes

In a Mennonite community in Bolivia, eight men were convicted of raping 130 women in Manitoba Colony over a four-year period from 2005 to 2009, by spraying "a chemical used to anesthetize cows" through the victims' open bedroom windows. The perpetrators would then wait for the women to be incapacitated, whereupon they entered the residences to commit the crimes. Later, the women would awaken to a pounding headache, find blood, semen or dirt on their sheets, and would sometimes discover their extremities had also been bound. Most did not remember the attacks, although a few had vague, fleeting memories of men on top of them. Several men and boys were also suspected of having been raped. While additional actors were thought to have participated, they were never identified nor prosecuted; in fact, the rapes did not stop with the incarceration of the original eight men. [29]

When two of these men were caught in the act of entering one of the women's homes, they implicated friends in the rapes to local authorities. Eventually nine Manitoba men, ages 19 to 43, were charged with using a spray adapted from an anesthetic by a veterinarian from a neighboring Mennonite colony to subdue their victims, then raping them. Eight of the accused were found guilty of rape, one escaped from the local jail before the end of the trial, and the veterinarian was found guilty of being an accomplice to the rapes. According to at least three residents of the colony, a local prosecutor, and a local journalist, these "ghost rapes" continue despite imprisonment of the men convicted in the 130 original rapes. [29]

Rape drugs

A date rape drug, also called a predator drug, is any drug that can be used as incapacitating agent to assist in the execution of drug facilitated sexual assault (DFSA). The most common types of DFSA are those in which a victim ingested drugs willingly for recreational purposes, or had them administered surreptitiously: [30] it is the latter type of assault that the term "date rape drug" most often refers to.

"The findings by Du Mont and colleagues support the view that alcohol plays a major role in drug-facilitated sexual assault. Previously, Weir noted that cases of drug-facilitated sexual assault were frequently found to involve alcohol, marijuana or cocaine, and were less likely to involve drugs, such as flunitrazepam (Rohypnol) and gamma-hydroxybutyrate, that are commonly described as being used in this context. Similar findings have been reported by others, including Hall and colleagues, in a recent retrospective study from Northern Ireland".

Butler B, Welch J (3 March 2009). "Drug-facilitated sexual assault". Canadian Medical Association Journal. 180 (5): 493–4. doi:10.1503/cmaj.090006. PMC   2645469 . PMID   19255067. [31]

"Knockout gas"

A fictional form of incapacitating agent, sometimes known as "knockout gas", has been a staple of pulp detective and science fiction novels, movies and television shows. It is presented in various forms, but generally is supposed to be a gas or aerosol that affords a harmless method of rendering characters quickly and temporarily unconscious without physical contact. This is in contrast to chloroform, a liquid anesthetic—itself a common element in genre fiction—that requires a vide victim to be physically subdued before it can be applied.

A number of notable fictional characters created in the early 20th century, both villains and heroes, were associated with the use of knockout gas: Fu Manchu, Dr. Mabuse, Doc Savage, Batman, and The Avenger. A military knockout gas called the "Gas of Peace" is an important plot device in H.G. Wells' 1936 movie Things to Come . It had become a familiar trope by the 1960s, when it was utilized in the X-Men comics. A famous example recurs in every opening sequence of the British TV series The Prisoner (1967–68).

The U.S. Army psychiatrist James S. Ketchum, who worked for almost a decade on the U.S. military's top secret psychochemical warfare program, relates a story relevant to the concept of a "knockout gas" in his 2006 memoir, Chemical Warfare Secrets Almost Forgotten. In 1970, Ketchum and his boss were visited by CIA agents for a brainstorming session at his Maryland laboratory. The agents wanted to know if an incapacitating agent (his specialty) could be used to intervene in the ongoing hijacking of a Tel Aviv aircraft by Palestinian terrorists without injuring the hostages.

We considered the pros and cons of using incapacitating agents and various other options. As it turned out, we could not imagine a scenario in which any available agent could be pumped into the airliner without the hijackers possibly reacting violently and killing passengers. Ultimately, the standoff was resolved by other means. [32]

Arguably, the use of fentanyl derivatives by Russian authorities in the 2002 Moscow hostage crisis [28] (see above) is a real-life instance of deployment of a "knockout gas". Of course, the criterion that the gas reliably render subjects temporarily and harmlessly unconscious was not fulfilled in this case, as the procedure killed about fifteen percent of those subjected to it. [27]

See also

Related Research Articles

<span class="mw-page-title-main">MKUltra</span> CIA program involving illegal experimentation on human test subjects (1953–1973)

Project MKUltra was an illegal human experiments program designed and undertaken by the U.S. Central Intelligence Agency (CIA) to develop procedures and identify drugs that could be used during interrogations to weaken people and force confessions through brainwashing and psychological torture. It began in 1953 and was halted in 1973. MKUltra used numerous methods to manipulate its subjects' mental states and brain functions, such as the covert administration of high doses of psychoactive drugs and other chemicals without the subjects' consent, electroshocks, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, and other forms of torture.

3-Quinuclidinyl benzilate (QNB) is an odorless and bitter-tasting military incapacitating agent. BZ is an antagonist of muscarinic acetylcholine receptors whose structure is the ester of benzilic acid with an alcohol derived from quinuclidine.

<span class="mw-page-title-main">Non-lethal weapon</span> Weapon intended to be less likely to kill a living target than conventional weapons

Non-lethal weapons, also called nonlethal weapons, less-lethal weapons, less-than-lethal weapons, non-deadly weapons, compliance weapons, or pain-inducing weapons are weapons intended to be less likely to kill a living target than conventional weapons such as knives and firearms with live ammunition. It is often understood that unintended or incidental casualties are risked wherever force is applied, however non-lethal weapons minimise the risk of casualties as much as possible. Non-lethal weapons are used in policing and combat situations to limit the escalation of conflict where employment of lethal force is prohibited or undesirable, where rules of engagement require minimum casualties, or where policy restricts the use of conventional force. However, these weapons occasionally cause serious injuries or death due to allergic reactions, improper use and/or other factors; for this reason the term "less-lethal" has been preferred by some organizations as it describes the risks of death more accurately than the term "non-lethal", which some have argued is a misnomer.

Project Coast was a 1980s top-secret chemical and biological weapons (CBW) program instituted by the apartheid-era government of South Africa. Project Coast was the successor to a limited postwar CBW program, which mainly produced the lethal agents CX powder and mustard gas, as well as non-lethal tear gas for riot control purposes. The program was headed by the cardiologist Wouter Basson, who was also the personal physician of South African Prime Minister P. W. Botha.

<span class="mw-page-title-main">United States and weapons of mass destruction</span>

The United States is known to have possessed three types of weapons of mass destruction: nuclear, chemical, and biological weapons. The U.S. is the only country to have used nuclear weapons on another country, when it detonated two atomic bombs over two Japanese cities of Hiroshima and Nagasaki during World War II. It had secretly developed the earliest form of the atomic weapon during the 1940s under the title "Manhattan Project". The United States pioneered the development of both the nuclear fission and hydrogen bombs. It was the world's first and only nuclear power for four years, from 1945 until 1949, when the Soviet Union produced its own nuclear weapon. The United States has the second-largest number of nuclear weapons in the world, after the Russian Federation.

<span class="mw-page-title-main">MKNAOMI</span> American biological warfare research program

MKNAOMI is the code name for a joint Department of Defense/CIA research program from the 1950s through to the 1970s. Unclassified information about the MKNAOMI program and the related Special Operations Division is scarce. It is generally reported to be a successor to the MKULTRA project focusing on biological projects including biological warfare agents—specifically, to store materials that could either incapacitate or kill a test subject and to develop devices for the diffusion of such materials.

Kolokol-1 is a synthetic opioid developed for use as an aerosolizable incapacitating agent. The exact chemical structure has not yet been revealed by the Russian government. It was originally thought by some sources to be a derivative of the potent opioid fentanyl, most probably 3-methylfentanyl dissolved in an inhalational anaesthetic as an organic solvent. However, independent analysis of residues on the Moscow theater hostage crisis hostages' clothing or in one hostage's urine found no fentanyl or 3-methylfentanyl. Two much more potent and shorter-acting agents, carfentanil and remifentanil, were found in the samples. They concluded that the agent used in the Moscow theater hostage crisis contained two fentanyl derivatives much stronger than fentanyl itself, sprayed in an aerosol mist.

Chemical, biological (CB) — and sometimes radiological — warfare agents were assigned what is termed a military symbol by the U.S. military until the American chemical and biological weapons programs were terminated. Military symbols applied to the CB agent fill, and not to the entire weapon. A chemical or biological weapon designation would be, for example, "Aero-14/B", which could be filled with GB, VX, TGB, or with a biological modification kit – OU, NU, UL, etc. A CB weapon is an integrated device of (1) agent, (2) dissemination means, and (3) delivery system.

<span class="mw-page-title-main">Edgewood Arsenal human experiments</span> US military chemical warfare research

From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility in Maryland. The purpose was to evaluate the impact of low-dose chemical warfare agents on military personnel and to test protective clothing, pharmaceuticals, and vaccines. A small portion of these studies were directed at psychochemical warfare and grouped under the prosaic title of the "Medical Research Volunteer Program" (1956–1975). The MRVP was also driven by intelligence requirements and the need for new and more effective interrogation techniques.

The United States biological weapons program officially began in spring 1943 on orders from U.S. President Franklin D. Roosevelt. Research continued following World War II as the U.S. built up a large stockpile of biological agents and weapons. Over the course of its 27-year history, the program weaponized and stockpiled seven bio-agents — Bacillus anthracis (anthrax), Francisella tularensis (tularemia), Brucella spp (brucellosis), Coxiella burnetii (Q-fever), Venezuelan equine encephalitis virus, Botulinum toxin (botulism), and Staphylococcal enterotoxin B. The US also pursued basic research on many more bio-agents. Throughout its history, the U.S. bioweapons program was secret. It was later revealed that laboratory and field testing had been common. The official policy of the United States was first to deter the use of bio-weapons against U.S. forces and secondarily to retaliate if deterrence failed.

The chemical agent used in the Moscow theatre hostage crisis of 26 October 2002 has never been definitively revealed by the Russian authorities, though many possible identities have been speculated. An undisclosed incapacitating agent was used by the Russian authorities in order to subdue the Chechen terrorists who had taken control of a crowded theater.

<span class="mw-page-title-main">Dimethylheptylpyran</span> Chemical compound

Dimethylheptylpyran is a synthetic analog of THC, which was invented in 1949 during attempts to elucidate the structure of Δ9-THC, one of the active components of Cannabis. DMHP is a pale yellow, viscous oil which is insoluble in water but dissolves in alcohol or non-polar solvents.

<span class="mw-page-title-main">EA-3167</span> Anticholinergic deliriant drug

EA-3167 is a potent and long-lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB) and to the bronchodilator drug tiotropium bromide. It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal incapacitating agents. EA-3167 has identical effects to QNB, but is even more potent and longer-lasting, with an effective dose when administered by injection of as little as 2.5 μg/kg, and a duration of 120–240 hours. However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.

<span class="mw-page-title-main">M43 BZ cluster bomb</span>

The M43 BZ cluster bomb, or simply M43 cluster bomb, was a U.S. chemical cluster bomb intended to deliver the incapacitating agent known as BZ. The weapon was produced in the early 1960s and all stocks of U.S. BZ were destroyed by 1989.

The M138 bomblet was a sub-munition of the U.S. chemical weapon, the M43 BZ cluster bomb. The bomblet contained BZ, an incapacitating agent and was developed with the M43 in 1962. The M138s, along with all other U.S. BZ weapons were destroyed during the 1980s.

Psychochemical warfare — or "drug weapons" — involves the use of psychopharmacological agents with the intention of incapacitating an adversary through the temporary induction of hallucinations or delirium. These agents have generally been considered chemical weapons and, more narrowly, constitute a specific type of incapacitating agent. Although never developed into an effective weapons system, psychochemical warfare theory and research—along with overlapping mind control drug research—was secretly pursued in the mid-20th century by the US military and Central Intelligence Agency (CIA) in the context of the Cold War. These research programs were ended when they came to light and generated controversy in the 1970s. The degree to which the Soviet Union developed or deployed similar agents during the same period remains largely unknown.

<span class="mw-page-title-main">Unethical human experimentation in the United States</span>

Numerous experiments which are performed on human test subjects in the United States are considered unethical, because they are performed without the knowledge or informed consent of the test subjects. Such tests have been performed throughout American history, but some of them are ongoing. The experiments include the exposure of humans to many chemical and biological weapons, human radiation experiments, injections of toxic and radioactive chemicals, surgical experiments, interrogation and torture experiments, tests which involve mind-altering substances, and a wide variety of other experiments. Many of these tests are performed on children, the sick, and mentally disabled individuals, often under the guise of "medical treatment". In many of the studies, a large portion of the subjects were poor, racial minorities, or prisoners.

The United States Biological Defense Program—in recent years also called the National Biodefense Strategy—refers to the collective effort by all levels of government, along with private enterprise and other stakeholders, in the United States to carry out biodefense activities.

James Sanford Ketchum was a psychiatrist and U.S. Army Medical Corps officer who worked for almost a decade (1960–1969) on the U.S. military’s top secret psychochemical warfare program at the Edgewood Arsenal, Maryland, which researched chemicals to be used to "incapacitate the minds" of adversaries.

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