Project MKUltra was a human experimentation program designed and undertaken by the U.S. Central Intelligence Agency (CIA) to develop procedures and identify drugs that could be used during interrogations to weaken individuals and force confessions through brainwashing and psychological torture. The term MKUltra is a CIA cryptonym: "MK" is an arbitrary prefix standing for the Office of Technical Service and "Ultra" is an arbitrary word out of a dictionary to denominate this project. The program has been widely condemned as a violation of individual rights and an example of the CIA’s abuse of power, with critics highlighting its disregard for consent and its corrosive impact on democratic principles.
3-Quinuclidinyl benzilate (QNB) is an odorless and bitter-tasting military incapacitating agent. BZ is an antagonist of muscarinic acetylcholine receptors whose structure is the ester of benzilic acid with an alcohol derived from quinuclidine.
Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness.
Porton Down is a science and defence technology campus in Wiltshire, England, just north-east of the village of Porton, near Salisbury. It is home to two British government facilities: a site of the Ministry of Defence's Defence Science and Technology Laboratory – known for over 100 years as one of the UK's most secretive and controversial military research facilities, occupying 7,000 acres (2,800 ha) – and a site of the UK Health Security Agency. Since 2018, part of the campus has housed Porton Science Park, which is owned and operated by Wiltshire Council and has private sector companies in the health, life science and defence and security sectors.
The United States is known to have possessed three types of weapons of mass destruction: nuclear, chemical, and biological weapons. As the country that invented nuclear weapons, the U.S. is the only country to have used nuclear weapons on another country, when it detonated two atomic bombs over two Japanese cities of Hiroshima and Nagasaki during World War II. It had secretly developed the earliest form of the atomic weapon during the 1940s under the title "Manhattan Project". The United States pioneered the development of both the nuclear fission and hydrogen bombs. It was the world's first and only nuclear power for four years, from 1945 until 1949, when the Soviet Union produced its own nuclear weapon. The United States has the second-largest number of nuclear weapons in the world, after the Russian Federation.
MKNAOMI is the code name for a joint Department of Defense/CIA research program from the 1950s through to the 1970s. Unclassified information about the MKNAOMI program and the related Special Operations Division is scarce. It is generally reported to be a successor to the MKULTRA project focusing on biological projects including biological warfare agents—specifically, to store materials that could either incapacitate or kill a test subject and to develop devices for the diffusion of such materials.
Harold Alexander Abramson was an American physician, remembered as an early advocate of therapeutic LSD. He played a significant role in the CIA's MKULTRA program to investigate the possible applications for LSD.
Herbicidal warfare is the use of substances primarily designed to destroy the plant-based ecosystem of an area. Although herbicidal warfare use chemical substances, its main purpose is to disrupt agricultural food production and/or to destroy plants which provide cover or concealment to the enemy, not to asphyxiate or poison humans and/or destroy human-made structures. Herbicidal warfare has been forbidden by the Environmental Modification Convention since 1978, which bans "any technique for changing the composition or structure of the Earth's biota".
Operation Midnight Climax was an operation carried out by the CIA as a sub-project of Project MKUltra, the mind-control research program that began in the 1950s. It was initially established in 1954 by Sidney Gottlieb and placed under the direction of the Federal Bureau of Narcotics in Boston, Massachusetts with the "Federal Narcotics Agent and CIA consultant" George Hunter White under the pseudonym of Morgan Hall. Dr. Sidney Gottlieb was a chemist who was chief of the Chemical Division of the Office of Technical Service of the CIA. Gottlieb based his plan for Project MKUltra and Operation Midnight Climax off interrogation method research under Project Artichoke. Unlike Project Artichoke, Operation Midnight Climax gave Gottlieb permission to test drugs on unknowing citizens, which made way for the legacy of this operation. Hundreds of federal agents, field operatives, and scientists worked on these programs before they were shut down in the 1960s.
From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility in Maryland. These experiments began after the conclusion of World War II, and continued until the public became aware of the experiments, resulting in significant outcry. The purpose was to evaluate the impact of low-dose chemical warfare agents on military personnel and to test protective clothing, pharmaceuticals, and vaccines. A small portion of these studies were directed at psychochemical warfare; grouped under the title "Medical Research Volunteer Program" (1956–1975), driven by intelligence requirements and the need for new and more effective interrogation techniques.
The United States biological weapons program officially began in spring 1943 on orders from U.S. President Franklin D. Roosevelt. Research continued following World War II as the U.S. built up a large stockpile of biological agents and weapons. Over the course of its 27-year history, the program weaponized and stockpiled seven bio-agents — Bacillus anthracis (anthrax), Francisella tularensis (tularemia), Brucella spp (brucellosis), Coxiella burnetii (Q-fever), Venezuelan equine encephalitis virus, Botulinum toxin (botulism), and Staphylococcal enterotoxin B. The US also pursued basic research on many more bio-agents. Throughout its history, the U.S. bioweapons program was secret. It was later revealed that laboratory and field testing had been common. The official policy of the United States was first to deter the use of bio-weapons against U.S. forces and secondarily to retaliate if deterrence failed.
Dimethylheptylpyran (DMHP) is a synthetic cannabinoid and analogue of tetrahydrocannabinol (THC). It was invented in 1949 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis. DMHP is a pale yellow, viscous oil which is insoluble in water but dissolves in alcohol or non-polar solvents.
EA-3167 is a potent and long-lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB) and to the bronchodilator drug tiotropium bromide. It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal incapacitating agents. EA-3167 has identical effects to QNB, but is even more potent and longer-lasting, with an effective dose when administered by injection of as little as 2.5 μg/kg, and a duration of 120–240 hours. However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.
The Deseret Test Center was a U.S. Army operated command in charge for testing chemical and biological weapons during the 1960s. The Deseret was headquartered at Fort Douglas, Utah, a former U.S. Army base.
The M138 bomblet was a sub-munition of the U.S. chemical weapon, the M43 BZ cluster bomb. The bomblet contained BZ, an incapacitating agent and was developed with the M43 in 1962. The M138s, along with all other U.S. BZ weapons were destroyed during the 1980s.
EA-3834 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.
Numerous experiments which were performed on human test subjects in the United States in the past are now considered to have been unethical, because they were performed without the knowledge or informed consent of the test subjects. Such tests have been performed throughout American history, but have become significantly less frequent with the advent and adoption of various safeguarding efforts. Despite these safeguards, unethical experimentation involving human subjects is still occasionally uncovered.
The United States chemical weapons program began in 1917 during World War I with the creation of the U.S. Army's Gas Service Section and ended 73 years later in 1990 with the country's practical adoption of the Chemical Weapons Convention. Destruction of stockpiled chemical weapons began in 1986 and was completed on July 7, 2023. The U.S. Army Medical Research Institute of Chemical Defense (USAMRICD), at Aberdeen Proving Ground, Maryland, continues to operate.
James Sanford Ketchum was a psychiatrist and U.S. Army Medical Corps officer who worked for almost a decade (1960–1969) on the U.S. military’s top secret psychochemical warfare program at the Edgewood Arsenal, Maryland, which researched chemicals to be used to "incapacitate the minds" of adversaries.
Poisoner in Chief: Sidney Gottlieb and the CIA Search for Mind Control is a 2019 book by The New York Times journalist and historian Stephen Kinzer. The book contains untold stories of a Central Intelligence Agency (CIA) chemist called Sidney Gottlieb, who tried to "find a way to control the human brain". In 1953, CIA director Allen Dulles appointed Gottlieb to "run the covert program".
