Edgewood Arsenal human experiments

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'Effects of Lysergic Acid Diethylamide (LSD) on Troops Marching' - 16mm film produced by the United States military circa 1958.

From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility in Maryland. [1] These experiments began after the conclusion of World War II, and continued until the public became aware of the experiments, resulting in significant outcry. The purpose was to evaluate the impact of low-dose chemical warfare agents on military personnel and to test protective clothing, pharmaceuticals, and vaccines. A small portion of these studies were directed at psychochemical warfare; grouped under the title "Medical Research Volunteer Program" (1956–1975), driven by intelligence requirements and the need for new and more effective interrogation techniques. [1]

Contents

Overall, about 6,720 soldiers took part in these experiments that involved exposures to more than 250 different chemicals, according to the Department of Defense (DoD). [2] Some of the volunteers exhibited symptoms at the time of exposure to these agents but long-term follow-up was not planned as part of the DoD studies. [3] The experiments were abruptly terminated by the Army in late 1975 amidst an atmosphere of scandal and recrimination as lawmakers accused researchers of questionable ethics. Many official government reports and civilian lawsuits followed in the wake of the controversy.

The chemical agents tested on volunteers included chemical warfare agents and other related agents: [3]

History

Background and rationale

After the conclusion of World War II, U.S. military researchers obtained formulas for the three nerve gases developed by the Nazis—tabun, soman, and sarin.

In 1947, the first steps of planning began when Dr. Alsoph H. Corwin, a professor of chemistry at Johns Hopkins University [4] [5] wrote the Chemical Corps Technical Command positing the potential for the use of specialized enzymes as so called "toxicological warfare agents". He went on to suggest that with intensive research, substances that depleted certain necessary nutrients could be found, which would, when administered on the battlefield, incapacitate enemy combatants. [4]

In 1948, the US Army Edgewood Chemical Biological Center began conducting research using the aforementioned nerve gases. These studies included a classified human subjects component at least as early as 1948, when "psychological reactions" were documented in Edgewood technicians. Initially, such studies focused solely on the lethality of the gases and its treatment and prevention.

A classified report entitled "Psychochemical Warfare: A New Concept of War" was produced in 1949 by Luther Wilson Greene, Technical Director of the Chemical and Radiological Laboratories at Edgewood. Greene called for a search for novel psychoactive compounds that would create the same debilitating mental side effects as those produced by nerve gases, but without their lethal effect. In his words,

Throughout recorded history, wars have been characterized by death, human misery, and the destruction of property; each major conflict being more catastrophic than the one preceding it ... I am convinced that it is possible, by means of the techniques of psychochemical warfare, to conquer an enemy without the wholesale killing of his people or the mass destruction of his property. [6]

In the late 1940s and early '50s, the U.S. Army worked with Harvard anesthesiologist Henry K. Beecher at its interrogation center at Camp King in Germany on the use of psychoactive compounds (mescaline, LSD), including human subject experiments and the debriefing of former Nazi physicians and scientists who had worked along similar lines before the end of the war. [7] In the 1950s, some officials in the U.S. Department of Defense publicly asserted that many "forms of chemical and allied warfare as more 'humane' than existing weapons. For example, certain types of 'psychochemicals' would make it possible to paralyze temporarily entire population centers without damage to homes and other structures." [8] Soviet advances in the same field were cited as a special incentive giving impetus to research efforts in this area, according to testimony by Maj. Gen. Marshall Stubbs, the Army's chief chemical officer.

In June 1955, the United States Department of Defense appointed a so-called Ad Hoc Study Group on Psychochemical Agents, which seems to have acted as a central authority on the research of psychochemical at Edgewood Arsenal and other installations where such experimentation occurred. [4]

General William M. Creasy, former chief chemical officer, U.S. Army, testified to the U.S. House of Representatives in 1959 that "provided sufficient emphasis is put behind it, I think the future lies in the psychochemicals." [9] This was alarming enough to a Harvard psychiatrist, E. James Lieberman, that he published an article entitled "Psychochemicals as Weapons" in The Bulletin of the Atomic Scientists in 1962. Lieberman, while acknowledging that "most of the military data" on the research ongoing at the Army Chemical Center was "secret and unpublished", asserted that "There are moral imponderables, such as whether insanity, temporary or permanent, is a more 'humane' military threat than the usual afflictions of war." [10]

The experiments

The Edgewood Arsenal human experiments took place from approximately 1948 to 1975 at the Medical Research Laboratories—which is now known as the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD)—at the Edgewood Area, Aberdeen Proving Ground, Maryland. The experiments involved at least 254 chemical substances, but focused mainly on midspectrum incapacitants, such as LSD, THC derivatives, benzodiazepines, and BZ. Around 7,000 US military personnel and 1,000 civilians were test subjects over almost three decades. [11] [12] [13] A result of these experiments was that BZ was weaponized, although never deployed. [14]

According to a DOD FAQ, the Edgewood Arsenal experiments involved the following "rough breakout of volunteer hours against various experimental categories": [15]

Experimental categoryPercentage of volunteer hours
Incapacitating compounds 29.9%
Lethal compounds14.5%
Riot control compounds14.2%
Protective equipment and clothing13.2%
Development evaluation and test procedures12.5%
Effects of drugs and environmental stress on human physiological mechanisms6.4%
Human factors tests (ability to follow instructions)2.1%
Other (visual studies, sleep deprivation, etc.)7.2%

Much of the experimentation at Edgewood Arsenal surrounded the modulation of acetylcholine or acetylcholinesterase, or the deactivation and reactivation of substances which did the same. [1] These experiments represented a significant enough proportion of the total experimentation to earn a dedicated volume in the main experimental documentation. Much of the follow up data on the acetylcholine related experiments are lacking or entirely missing, due to a combination of remaining classification and failures on the part of the United States Department of Veterans Affairs and United States Department of Defense to follow the subjects of the experimentation. [16]

Anticholinesterase experiments

Anticholinesterases are substances that interfere with the central nervous system and the peripheral nervous system by inhibiting acetylcholinesterase and therefore sustaining the effect of acetylcholine or butyrylcholine within the chemical synapses, [17] resulting in a cholinergic crisis, and possibly death if untreated. [18]

Long term side effects of exposure to anticholinesterases, including at levels below the threshold for profound illness and death can include paralysis and peripheral neuropathy, [19] sleep disturbance, [20] genetic mutation and cancer. [1] In total, 1,406 subjects were tested with 16 agents, some of which included reactivating agents and protective agents. [1]

Anticholinergic experiments

Anticholinergics are substances that interfere with the central nervous system and the peripheral nervous system by inhibiting acetylcholine, resulting in what is essentially the opposite effect of an cholinesterase inhibitor to the extreme. [21] This can result in anticholinergic syndrome, and possibly death if untreated. [22] [23]

Available data from both experiment patients [1] and pharmaceutical research indicates that short-term exposure to anticholinergic compounds, especially the extremely limited exposures described in the documentation is associated with no long-term effects. It is important to note however, that in the decades since their introduction to medical use, research has begun to suggest a causal relationship between long term anticholinergic drug use and later development or worsening of dementia. [24] In total, 1,752 subjects were tested with 21 agents, some of whom received exposure to more than one chemical agent. [1]

Cholinesterase reactivator experiments

Cholinesterase reactivators are substances which reactivate acetylcholinesterase which has been inactivated by an anticholinesterase. [25] [1] This action can be precipitated through a variety of mechanisms, including directly binding and deactivating the anticholinesterase itself, [26] blocking the reaction between the anticholinesterase and the acetylcholinesterase, [27] changing the release of acetylcholine, [28] blocking acetylcholine's cholinolytic effect, [29] or by increasing the excretion of the anticholinesterase. [30]

Available data from the experiments [1] and from prescribing information [31] from modern marketing of these substances concludes that little risk exists of long term effects from exposure. It is noted, however, in both the prescribing information for modern variants and in toxicological research on the subject that it has been the subject of insufficient research to conclude this beyond a reasonable doubt. [32] [31] In total, 219 subjects were tested with 4 agents. [1]

The 1976 report on the matter identifies the sole objective of the psychochemical experiments as determining the impact on morale and efficacy such agents would have on military units. [4] It appears that these experiments specifically were first called for in 1954 after the attendees of the First Psychochemical Conference informed the Department of Defense that human trials were indicated. In 1957, the first report of such trials were received, detailing a four-person experiment wherein they attempted to successfully decontaminate themselves of a mock agent while under the influence of LSD. [33]

LSD experiments

The LSD experiments are perhaps the best documented of the psychochemical experiments of the time, garnering at least two significant independent reports. [4] [33] [34] LSD is a Psychedelic drug that acts as a dopamine and serotonin agonist [35] [36] precipitating a hallucinogenic effect, leading to hallucinations, euphoria, and a wide variety of physiological symptoms. [37]

Available data describes a wide range of doses used in the experiments, from approximately 2μg/kg to 16μg/kg [33] A typical dose for recreational use is around 100μg, [38] [39] [40] or about 1.1μg/kg for the average adult male in the U.S., [41] meaning the lowest dose used in experimentation was almost twice the typical recreational dose, and the highest dose exceeded fifteen times the typical recreational dose. Because of limited documentation, it is difficult to ascertain which experiments occurred at which installations, but available documentation describes several general types of experiments; which included presenting individuals with radar symbols for interpretation, having them track a simulated aircraft, having them read a map, having them interpret meteorological data, and having them attempt to defend an installation against a simulated hostile air craft attack with 40-mm antiaircraft automatic weapons. [33] Results varied between experiments, but typically showed significant impairment at all doses, with impairment increasing as dose did. [4] [33] [34]

Available data from the experiments [34] concluded that long term effects from LSD exposure in not only the Edgewood Arsenal Experiments, but in the other associated experiments conducted concurrently by the Army Chemical Corps as well were minimal, with the exception of a possible small increase in congenital heart disease in offspring of the experimental subjects, and neuropsychological abnormalities in 9% of the participants which could not be explained by etiological explanations other than LSD exposure, most of which were considered mild. It is reported that all testing of LSD at Edgewood Arsenal and in general on behalf of the Army Chemical Corps was abandoned on or around April 1963. [4]

BZ experiments

3-Quinuclidinyl benzilate, or BZ is a substance that interferes with the central nervous system and the peripheral nervous system by inhibiting acetylcholine. Existing documentation admits only that the substance was tested at Edgewood Arsenal, and all other data, including the medical records from the subjects are completely missing. [4] Because of the extremely limited data, speculation on possible side effects from exposure is impossible.

Scandal and termination

In September 1975, the Medical Research Volunteer Program was discontinued and all resident volunteers were removed from the Edgewood installation. The founder and director of the program, Van Murray Sim, was called before Congress and chastised by outraged lawmakers, who questioned the absence of follow-up care for the human volunteers. An Army investigation subsequently found no evidence of serious injuries or deaths associated with the MRVP, but deplored both the recruiting process and the informed consent approach, which they characterized as "suggest[ing] possible coercion".

Aftermath

Government reports

1982-85 IOM report
The Institute of Medicine (IOM) published a three-volume report on the Edgewood research in 1982–1985, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. [42]

The three volumes were:

The National Academy of Sciences, which oversees the IOM, sent a questionnaire to all of the former volunteers that could be located, approximately 60% of the total. The lack of a detailed record hampered the investigation. The study could not rule out long-term health effects related to exposure to the nerve agents. It concluded that "Whether the subjects at Edgewood incurred these changes [depression, cognitive deficits, tendency to suicide] and to what extent they might now show these effects are not known". With regard specifically to BZ and related compounds, the IOM study concluded that "available data suggest that long-term toxic effects and/or delayed sequellae are unlikely".

2004 GAO report
A Government Accounting Office report of May 2004, Chemical and Biological Defense: DOD Needs to Continue to Collect and Provide Information on Tests and Potentially Exposed Personnel (pp. 1, 24), stated:

[In 1993 and 1994] we [...] reported that the Army Chemical Corps conducted a classified medical research program for developing incapacitating agents. This program involved testing nerve agents, nerve agent antidotes, psycho chemicals, and irritants. The chemicals were given to volunteer service members at Edgewood Arsenal, Maryland; Dugway Proving Ground, Utah; and Forts Benning, Bragg, and McClellan. In total, Army documents identified 7,120 Army and Air Force personnel who participated in these tests. Further, GAO concluded that precise information on the scope and the magnitude of tests involving human subjects was not available, and the exact number of human subjects might never be known. [43]

Safety debates

The official position of the Department of Defense, based on the three-volume set of studies by the Institute of Medicine mentioned above, is that they "did not detect any significant long-term health effects on the Edgewood Arsenal volunteers". [13] The safety record of the Edgewood Arsenal experiments was also defended in the memoirs of psychiatrist and retired colonel James Ketchum, a key scientist: [44]

Over a period of 20 years, more than 7,000 volunteers spent an estimated total of 14,000 months at Edgewood Arsenal. To my knowledge, not one of them died or suffered a serious illness or permanent injury. That adds up to 1,167 man-years of survival. Statistically, at least one out of a thousand young soldiers chosen at random might be expected to expire during any one-year period. By this logic, Edgewood was possibly the safest military place in the world to spend two months.

As late as 2014, information was incomplete; IOM could not conduct adequate medical studies related to similar former US biowarfare programs, because relevant classified documents had not been declassified and released.

The committee's understanding is that additional, and potentially relevant, material on SHAD tests exists and remains classified. The IOM committee requested declassification of 21 additional elements from at least nine documents from DoD in August 2012. In January 2014, an additional request was made for release of multiple films made of Project SHAD tests. None of the requested materials were cleared for public release as of this writing (2016). [45]

Even a book critical of the program, written by Lynn C. Klotz and Edward J. Sylvester, acknowledges that:

Unlike the CIA program, research subjects [at Edgewood] all signed informed consent forms, both a general one and another related to any experiment they were to participate in. Experiments were carried out with safety of subjects a principal focus. [...] At Edgewood, even at the highest doses it often took an hour or more for incapacitating effects to show, and the end-effects usually did not include full incapacitation, let alone unconsciousness. After all, the Edgewood experimenters were focused on disabling soldiers in combat, where there would be tactical value simply in disabling the enemy. [12]

Lawsuits

The U.S. Army believed that legal liability could be avoided by concealing the experiments. However once the experiments were uncovered, the US Senate also concluded questionable legality of the experiments and strongly condemned them.

In the Army's tests, as with those of the CIA, individual rights were ... subordinated to national security considerations; informed consent and follow-up examinations of subjects were neglected in efforts to maintain the secrecy of the tests. Finally, the command and control problems which were apparent in the CIA's programs are paralleled by a lack of clear authorization and supervision in the Army's programs.(S. Rep., at 411.[5]) [46]

In the 1990s, the law firm Morrison & Foerster agreed to take on a class-action lawsuit against the government related to the Edgewood volunteers. The plaintiffs collectively referred to themselves as the "Test Vets".

In 2009 a lawsuit was filed by veterans rights organizations Vietnam Veterans of America, and Swords to Plowshares, and eight Edgewood veterans or their families against CIA, the U.S. Army, and other agencies. The complaint asked the court to determine that defendants' actions were illegal and that the defendants have a duty to notify all victims and to provide them with health care. In the suit, Vietnam Veterans of America, et al. v. Central Intelligence Agency, et al. Case No. CV-09-0037-CW, U.S.D.C. (N.D. Cal. 2009), the plaintiffs did not seek monetary damages. Instead, they sought only declaratory and injunctive relief and redress for what they claimed was several decades of neglect and the U.S. government's use of them as human guinea pigs in chemical and biological agent testing experiments.

The plaintiffs cited:

On July 24, 2013, United States District Court Judge Claudia Wilken issued an order granting in part and denying in part plaintiffs' motion for summary judgment and granting in part and denying in part defendants' motion for summary judgment. The court resolved all of the remaining claims in the case and vacated trial. The court granted the plaintiffs partial summary judgment concerning the notice claim: summarily adjudicating in plaintiffs' favor, finding that "the Army has an ongoing duty to warn" and ordering "the Army, through the DVA or otherwise, to provide test subjects with newly acquired information that may affect their well-being that it has learned since its original notification, now and in the future as it becomes available". The court granted the defendants' motion for summary judgment with respect to the other claims. [47]

On appeal in Vietnam Veterans of America v. Central Intelligence Agency, a panel majority held in July 2015 that Army Regulation 70-25 (AR 70-25) created an independent duty to provide ongoing medical care to veterans who participated in U.S. chemical and biological testing programs. The prior finding held that the Army has an ongoing duty to seek out and provide "notice" to former test participants of any new information that could potentially affect their health. [48]

List of notable EA (Edgewood Arsenal) numbered chemicals

List of notable CS (Chemical Structure) and CAS (Chemical Abstracts Service) numbered chemicals used in the Edgewood Arsenal Experiments

The following chemicals were identified by the National Academies of Sciences, Engineering, and Medicine as having been used in the Edgewood Arsenal Experiments, though they did not receive an EA number designation. [1]

See also

Related Research Articles

Nerve agents, sometimes also called nerve gases, are a class of organic chemicals that disrupt the mechanisms by which nerves transfer messages to organs. The disruption is caused by the blocking of acetylcholinesterase (AChE), an enzyme that catalyzes the breakdown of acetylcholine, a neurotransmitter. Nerve agents are irreversible acetylcholinesterase inhibitors used as poison.

<span class="mw-page-title-main">Aberdeen Proving Ground</span> U.S. Army facility located adjacent to Aberdeen, Maryland

Aberdeen Proving Ground (APG) is a U.S. Army facility located adjacent to Aberdeen, Harford County, Maryland, United States. More than 7,500 civilians and 5,000 military personnel work at APG. There are 11 major commands among the tenant units, including:

3-Quinuclidinyl benzilate (QNB) is an odorless and bitter-tasting military incapacitating agent. BZ is an antagonist of muscarinic acetylcholine receptors whose structure is the ester of benzilic acid with an alcohol derived from quinuclidine.

Incapacitating agent is a chemical or biological agent which renders a person unable to harm themselves or others, regardless of consciousness.

<span class="mw-page-title-main">Soman</span> Chemical compound (nerve agent)

Soman is an extremely toxic chemical substance. It is a nerve agent, interfering with normal functioning of the mammalian nervous system by inhibiting the enzyme cholinesterase. It is an inhibitor of both acetylcholinesterase and butyrylcholinesterase. As a chemical weapon, it is classified as a weapon of mass destruction by the United Nations according to UN Resolution 687. Its production is strictly controlled, and stockpiling is outlawed by the Chemical Weapons Convention of 1993 where it is classified as a Schedule 1 substance. Soman was the third of the so-called G-series nerve agents to be discovered along with GA (tabun), GB (sarin), and GF (cyclosarin).

<span class="mw-page-title-main">VX (nerve agent)</span> Chemical compound and chemical warfare nerve agent

VX is an extremely toxic synthetic chemical compound in the organophosphorus class, specifically, a thiophosphonate. In the class of nerve agents, it was developed for military use in chemical warfare after translation of earlier discoveries of organophosphate toxicity in pesticide research. In its pure form, VX is an oily, relatively non-volatile liquid that is amber-like in colour. Because of its low volatility, VX persists in environments where it is dispersed.

<span class="mw-page-title-main">Cholinesterase</span> Esterase that lyses choline-based esters

The enzyme cholinesterase (EC 3.1.1.8, choline esterase; systematic name acylcholine acylhydrolase) catalyses the hydrolysis of choline-based esters:

<span class="mw-page-title-main">Diisopropyl fluorophosphate</span> Chemical compound

Diisopropyl fluorophosphate (DFP) or Isoflurophate is an oily, colorless liquid with the chemical formula C6H14FO3P. It is used in medicine and as an organophosphorus insecticide. It is stable, but undergoes hydrolysis when subjected to moisture.

<span class="mw-page-title-main">Dimethylheptylpyran</span> Chemical compound

Dimethylheptylpyran (DMHP) is a synthetic cannabinoid and analogue of tetrahydrocannabinol (THC). It was invented in 1949 during attempts to elucidate the structure of Δ9-THC, one of the active components of cannabis. DMHP is a pale yellow, viscous oil which is insoluble in water but dissolves in alcohol or non-polar solvents.

<span class="mw-page-title-main">EA-3167</span> Anticholinergic deliriant drug

EA-3167 is a potent and long-lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB) and to the bronchodilator drug tiotropium bromide. It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, in an attempt to develop non-lethal incapacitating agents. EA-3167 has identical effects to QNB, but is even more potent and longer-lasting, with an effective dose when administered by injection of as little as 2.5 μg/kg, and a duration of 120–240 hours. However unlike QNB, EA-3167 was never weaponized or manufactured in bulk.

<span class="mw-page-title-main">Psychochemical warfare</span> Warfare involving the usage of psychopharmacological agents

Psychochemical warfare involves the use of psychopharmacological agents with the intention of incapacitating an adversary through the temporary induction of hallucinations or delirium. These agents, often called "drug weapons", are generally considered chemical weapons and, more narrowly, constitute a specific type of incapacitating agent.

<span class="mw-page-title-main">EA-3443</span> Chemical compound

EA-3443 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

<span class="mw-page-title-main">CAR-302,196</span> Chemical compound

CAR-302,196 is a moderately potent and relatively short lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

<span class="mw-page-title-main">EA-3580</span> Chemical compound

EA-3580 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

<span class="mw-page-title-main">CAR-226,086</span> Chemical compound

CAR-226,086 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

<span class="mw-page-title-main">EA-3834</span> Chemical compound

EA-3834 is a potent anticholinergic deliriant drug with a fairly long duration of action, related to the chemical warfare agent 3-quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

<span class="mw-page-title-main">EA-3148</span> Chemical compound

EA-3148 is a "V-series" nerve agent related to the better-known compounds VX and VR. It was studied by both the US and Soviet chemical weapons programmes during the Cold War, and is notable as the only V-series organophosphate nerve agent specifically identified in public domain sources as having a higher absolute potency as an acetylcholinesterase inhibitor than VX. However, both the US and Soviet investigations of the compound concluded that despite its high potency, the physicochemical properties of the substance made it unsuitable for weaponisation, and further research was not conducted.

<span class="mw-page-title-main">CAR-301,060</span> Chemical compound

CAR-301,060 is a potent and long lasting anticholinergic deliriant drug, related to the chemical warfare agent 3-Quinuclidinyl benzilate (QNB). It was developed under contract to Edgewood Arsenal during the 1960s as part of the US military chemical weapons program, during research to improve upon the properties of earlier agents such as QNB.

James Sanford Ketchum was a psychiatrist and U.S. Army Medical Corps officer who worked for almost a decade (1960–1969) on the U.S. military’s top secret psychochemical warfare program at the Edgewood Arsenal, Maryland, which researched chemicals to be used to "incapacitate the minds" of adversaries.

<span class="mw-page-title-main">CAR-302,282</span> Delirant drug

CAR-302,282 (302282, NSC-263548, α-(3-Methylbut-1-yn-3-enyl)mandelic acid 1-methyl-4-piperidyl ester) is an anticholinergic deliriant drug, invented under contract to Edgewood Arsenal in the 1960s. It is a potent incapacitating agent with an ED50 of 1.2μg/kg and a high central to peripheral effects ratio, and a relatively short duration of action compared to other similar drugs of around 6-10 hours. Despite its favorable properties it was relatively little researched compared to more high profile compounds from the series such as EA-3167 and EA-3580.

References

General sources

Citations

  1. 1 2 3 4 5 6 7 8 9 10 11 Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents, Commission on Life Sciences. The National Academies Press. In three volumes:
  2. ↑ "War Related Illness and Injury Study Center: Edgewood-Aberdeen Experiments". www.warrelatedillness.va.gov. United States Department of Veterans Affairs . Retrieved 2024-09-15.
  3. 1 2 "Edgewood / Aberdeen Experiments". VA Public Health Military Exposures. United States Department of Veterans Affairs. April 1, 2013. Retrieved October 1, 2013.
  4. 1 2 3 4 5 6 7 8 Taylor, JR; Johnson, WN (1976). "Research Report Concerning the Use of Volunteers in Chemical Agent Research DAIG-IN 21-75" (PDF). GovernmentAttic.org. United States Department of the Army Office of the Inspector General and Auditor General. Retrieved September 17, 2024– via [[United States Government Printing Office.
  5. ↑ "Alsoph H. Corwin Chair in Chemistry - Named Deanships, Directorships, and Professorships". Johns Hopkins University . 2016-07-11. Retrieved 2024-09-17.
  6. ↑ Greene, L. Wilson, "Psychochemical Warfare: A New Concept of War", U. S. Army Chemical Center, Edgewood Arsenal, Maryland; August 1949.
  7. ↑ George A. Mashour (2009), "Altered States: LSD and the Anesthesia Laboratory of Henry Knowles Beecher" Archived 2015-03-19 at the Wayback Machine , CSA Bulletin , Winter issue, pp 68-74.
  8. ↑ "US Plans Study of Gas Warfare" Archived 2020-01-26 at the Wayback Machine [New York Times News Service], Sunday, 9 August 1959, The Milwaukee Journal , Part I, pg 2.
  9. ↑ "Chemical, Biological, and Radiological Warfare Agents", Hearings before the Committee on Science and Astronautics, U.S. House of Representatives, June 1959 (No. 22).
  10. ↑ Lieberman, E. James (1962), "Psychochemicals as Weapons"; Bulletin of the Atomic Scientists (January issue).
  11. ↑ Malcolm Dando; Martin Furmanski (2006). "Midspectrum Incapacitant Programs". In Mark Wheelis; Lajos Rózsa (eds.). Deadly Cultures: Biological Weapons since 1945. Harvard University Press. pp. 245–246. ISBN   978-0-674-04513-2.
  12. 1 2 Lynn C. Klotz; Edward J. Sylvester (2009). Breeding Bio Insecurity: How U.S. Biodefense Is Exporting Fear, Globalizing Risk, and Making Us All Less Secure. University of Chicago Press. p. 33. ISBN   978-0-226-44407-9.
  13. 1 2 "Edgewood Arsenal Chemical Agent Exposure Studies 1955–1975". United States Department of Defense, Force Health Protection & Readiness, Medical Countermeasures website. Archived from the original on 2013-07-24. Retrieved 2013-06-19.
  14. ↑ Researchers tested pot, LSD on Army volunteers Richard Willing, USA Today, 4/6/2007
  15. ↑ Edgewood Arsenal Chemical Agent Exposure Studies FAQs. What types of tests were conducted at Edgewood? Archived 2015-06-21 at the Wayback Machine September 08, 2008
  16. ↑
  17. ↑ Colovic, Mirjana B.; Krstic, Danijela Z.; Lazarevic-Pasti, Tamara D.; Bondzic, Aleksandra M.; Vasic, Vesna M. (2013-04-01). "Acetylcholinesterase Inhibitors: Pharmacology and Toxicology". Current Neuropharmacology. 11 (3): 315–335. doi:10.2174/1570159x11311030006. ISSN   1570-159X. PMC   3648782 . PMID   24179466.
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  20. ↑ Metcalf, David R.; Holmes, Joseph H. (June 1969). "EEG, PSYCHOLOGICAL, AND NEUROLOGICAL ALTERATIONS IN HUMANS WITH ORGANOPHOSPHORUS EXPOSURE*". Annals of the New York Academy of Sciences. 160 (1): 357–365. Bibcode:1969NYASA.160..357M. doi:10.1111/j.1749-6632.1969.tb15857.x. ISSN   0077-8923. PMID   5257403.
  21. ↑ Sanders, Kenton M.; Koh, Sang Don; Ward, Sean M. (2012), "Organization and Electrophysiology of Interstitial Cells of Cajal and Smooth Muscle Cells in the Gastrointestinal Tract", Physiology of the Gastrointestinal Tract, Elsevier, pp. 511–556, doi:10.1016/b978-0-12-382026-6.00018-x, ISBN   978-0-12-382026-6 , retrieved 2024-09-15
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