Miotine

Miotine

Names
IUPAC name [3-[1-(Dimethylamino)ethyl]phenyl] N-methylcarbamate
Other names AR-28 [1] T-1843 [1]
Identifiers
CAS Number	4464-16-8  Y
3D model (JSmol)	Interactive image
ChemSpider	41955  N
KEGG	C11763  N
PubChem CID	46093
UNII	9Z3ZT09RRU  Y
CompTox Dashboard (EPA)	DTXSID10275489
InChI InChI=1S/C12H18N2O2/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2/h5-9H,1-4H3,(H,13,15) N Key: KQOUPMYYRQWZLI-UHFFFAOYSA-N N InChI=1/C12H18N2O2/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2/h5-9H,1-4H3,(H,13,15) Key: KQOUPMYYRQWZLI-UHFFFAOYAX
SMILES CC(C1=CC(=CC=C1)OC(=O)NC)N(C)C
Properties
Chemical formula	C12H18N2O2
Molar mass	222.288 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N  verify  (what is  YN ?) Infobox references

Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically. ^[2]

Unlike the miotine analog neostigmine, it doesn't have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood–brain barrier and cause unwanted central nervous system (CNS) side effects. ^[3]

Miotine equilibrium

See also

• Neostigmine
• T-1123
• TL-1238
• TMTFA

References

1. Chemical Warfare Agents, and Related Chemical Problems. Parts I-II. 1958.
2. "Archived copy" (PDF). Archived from the original (PDF) on 2009-05-09. Retrieved 2008-01-04.
3. "An introduction to drugs, their action and discovery" (PDF).