Retinoic acid-inducible orphan G protein-coupled receptor

Last updated
G protein-coupled receptor, family C, group 5, member A
Identifiers
SymbolGPRC5A
Alt. symbolsRAIG1, RAI3
NCBI gene 9052
HGNC 9836
OMIM 604138
RefSeq NM_003979
UniProt Q8NFJ5
Other data
Locus Chr. 12 p13-p12.3
G protein coupled receptor, family C, group 5, member B
Identifiers
SymbolGPRC5B
Alt. symbolsRAIG2
NCBI gene 51704
HGNC 13308
OMIM 605948
RefSeq NM_016235
UniProt Q9NZH0
Other data
Locus Chr. 16 p12
G protein-coupled receptor, family C, group 5, member C
Identifiers
SymbolGPRC5C
Alt. symbolsRAIG3
NCBI gene 55890
HGNC 13309
OMIM 605949
RefSeq NM_022036
UniProt Q9NQ84
Other data
Locus Chr. 17 q25
G protein-coupled receptor, family C, group 5, member D
Identifiers
SymbolGPRC5D
NCBI gene 55507
HGNC 13310
OMIM 607437
RefSeq NM_018654
UniProt Q9NZD1
Other data
Locus Chr. 12 p13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid. [1] [2] [3] [4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway. [5]

Related Research Articles

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<span class="mw-page-title-main">Frizzled-3</span> Protein-coding gene in the species Homo sapiens

Frizzled-3(Fz-3) is a protein that in humans is encoded by the FZD3 gene.

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<span class="mw-page-title-main">GPRC5B</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">GPRC5C</span> Protein-coding gene in the species Homo sapiens

G-protein coupled receptor family C group 5 member C is a protein that in humans is encoded by the GPRC5C gene.

<span class="mw-page-title-main">GPRC5D</span>

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<span class="mw-page-title-main">GPRC5A</span>

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene. This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1); two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1). Its encoded protein was later named Retinoic acid-induced protein 3.

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<span class="mw-page-title-main">LRP6</span>

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References

  1. Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi: 10.1074/jbc.273.52.35008 . PMID   9857033.
  2. Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID   10783259.
  3. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID   10945465.
  4. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID   11311935.
  5. Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC   2854581 . PMID   17521608.