Parathyroid hormone 2 receptor

Last updated
PTH2R
Identifiers
Aliases PTH2R , PTHR2, parathyroid hormone 2 receptor
External IDs OMIM: 601469; MGI: 2180917; HomoloGene: 3701; GeneCards: PTH2R; OMA:PTH2R - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001309516
NM_005048

NM_139270

RefSeq (protein)

NP_001296445
NP_005039
NP_001358834
NP_001358835
NP_001358836

Contents

NP_644676

Location (UCSC) Chr 2: 208.36 – 208.85 Mb Chr 1: 65.32 – 65.43 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene. [5]

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas. [5]

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding. [6]

Mechanism

It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by Gs protein, which activates adenylyl cyclase. [7]

See also

Related Research Articles

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Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates the serum calcium concentration through its effects on bone, kidney, and intestine.

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<span class="mw-page-title-main">Parathyroid chief cell</span>

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<span class="mw-page-title-main">ACTH receptor</span> Mammalian protein found in Homo sapiens

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The calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney and the brain. In the parathyroid gland, it controls calcium homeostasis by regulating the release of parathyroid hormone (PTH). In the kidney it has an inhibitory effect on the reabsorption of calcium, potassium, sodium, and water depending on which segment of the tubule is being activated.

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<span class="mw-page-title-main">Parathyroid hormone 1 receptor</span> Protein-coding gene in the species Homo sapiens

Parathyroid hormone/parathyroid hormone-related peptide receptor, also known as parathyroid hormone 1 receptor (PTH1R), is a protein that in humans is encoded by the PTH1R gene. PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).

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<span class="mw-page-title-main">Thyroid hormone receptor beta</span> Protein-coding gene in the species Homo sapiens

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a nuclear receptor protein that in humans is encoded by the THRB gene.

<span class="mw-page-title-main">Tachykinin receptor 2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">TIP39</span> Protein-coding gene in the species Homo sapiens

Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000144407 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025946 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: PTH2R parathyroid hormone 2 receptor".
  6. Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D (2017). "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5". Biochemical Pharmacology. 127: 71–81. doi:10.1016/j.bcp.2016.12.013. PMC   5303546 . PMID   28012961.
  7. Dobolyi, Arpad; Dimitrov, Eugene; Palkovits, Miklos; Usdin, Ted B. (2012). "The neuroendocrine functions of the parathyroid hormone 2 receptor". Frontiers in Endocrinology. 3: 121. doi: 10.3389/fendo.2012.00121 . PMC   3465808 . PMID   23060860.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.