GPR110

Last updated
ADGRF1
Identifiers
Aliases ADGRF1 , KPG_012, PGR19, hGPCR36, GPR110, adhesion G protein-coupled receptor F1
External IDs OMIM: 617430; MGI: 1924846; HomoloGene: 124643; GeneCards: ADGRF1; OMA:ADGRF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_025048
NM_153840

NM_133776

RefSeq (protein)

NP_079324
NP_722582

NP_598537

Location (UCSC) Chr 6: 47 – 47.04 Mb Chr 17: 43.58 – 43.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. [5] [6] This gene encodes a member of the adhesion-GPCR receptor family. [7] Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153292 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041293 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Lett. 531 (3): 407–14. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
  6. "Entrez Gene: GPR110 G protein-coupled receptor 110".
  7. Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN   978-1-4419-7912-4.
  8. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". EMBO J. 31 (6): 1364–78. doi:10.1038/emboj.2012.26. PMC   3321182 . PMID   22333914.

Further reading