Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. [5] [6] [7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [8] [9] [10]
GPR124 has been shown to interact with DLG1 [11] and is involved in the Wnt/β-catenin signaling pathway along with RECK. [12] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain. [13] GPR124 (ADGRA2) was predicted using SSHHPS.
Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.