GPR124

Last updated

ADGRA2
Identifiers
Aliases ADGRA2 , G protein-coupled receptor 124, TEM5, GPR124, adhesion G protein-coupled receptor A2
External IDs OMIM: 606823; MGI: 1925810; HomoloGene: 13112; GeneCards: ADGRA2; OMA:ADGRA2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_032777

NM_054044

RefSeq (protein)

NP_116166

NP_473385

Location (UCSC) Chr 8: 37.78 – 37.84 Mb Chr 8: 27.58 – 27.61 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 124 is a protein that in humans is encoded by the GPR124 gene. [5] [6] [7] It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. [8] [9] [10]

Contents

Interactions

GPR124 has been shown to interact with DLG1 [11] and is involved in the Wnt/β-catenin signaling pathway along with RECK. [12] GPR124 is the predicted target of several Group IV (+)ssRNA neuroinvasive viruses; proteolytic cleavage of GPR124 by these viral proteases may be important for entry into the brain. [13] GPR124 (ADGRA2) was predicted using SSHHPS.

Zebrafish embryos with Gpr124 loss of function demonstrate severe angiogenic deficiencies in the central nervous system.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000020181 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031486 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Carson-Walter EB, Watkins DN, Nanda A, Vogelstein B, Kinzler KW, St Croix B (September 2001). "Cell surface tumor endothelial markers are conserved in mice and humans". Cancer Research. 61 (18): 6649–6655. PMID   11559528.
  6. Fredriksson R, Gloriam DE, Höglund PJ, Lagerström MC, Schiöth HB (February 2003). "There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini". Biochemical and Biophysical Research Communications. 301 (3): 725–734. doi:10.1016/S0006-291X(03)00026-3. PMID   12565841.
  7. "Entrez Gene: GPR124 G protein-coupled receptor 124".
  8. Stacey M, Yona S (2011). AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN   978-1-4419-7912-4.
  9. Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. doi: 10.1016/S0014-5793(02)03574-3 . PMID   12435584. S2CID   7449692.
  10. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC   3321182 . PMID   22333914.
  11. Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y (May 2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein". Oncogene. 23 (22): 3889–3897. doi:10.1038/sj.onc.1207495. PMID   15021905. S2CID   6082566.
  12. Vanhollebeke B, Stone OA, Bostaille N, Cho C, Zhou Y, Maquet E, et al. (June 2015). Rossant J (ed.). "Tip cell-specific requirement for an atypical Gpr124- and Reck-dependent Wnt/β-catenin pathway during brain angiogenesis". eLife. 4: e06489. doi: 10.7554/eLife.06489 . PMC   4456509 . PMID   26051822.
  13. Doctor KZ, Gilmour E, Recarte M, Beatty TR, Shifa I, Stangel M, et al. (February 2023). "Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses". Viruses. 15 (2): 542. doi: 10.3390/v15020542 . PMC   9961674 . PMID   36851756.

Further reading