GPR182

GPR182
Identifiers
Aliases	GPR182 , 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDs	OMIM: 605307; MGI: 109545; HomoloGene: 5255; GeneCards: GPR182; OMA:GPR182 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.3 Start 56,994,492 bp [1] End 56,998,447 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 D3|10 75.07 cM Start 127,583,145 bp [2] End 127,587,601 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle spleen sperm tendon of biceps brachii left adrenal cortex right adrenal cortex tibialis anterior muscle liver right testis left testis Top expressed in yolk sac atrium mesenteric lymph nodes right lung liver left lobe of liver right lung lobe endocardial cushion left lung lobe embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component plasma membrane membrane intracellular anatomical structure integral component of membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway intracellular signal transduction signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11318 11536 Ensembl ENSG00000166856 ENSMUSG00000058396 UniProt O15218 P43142 RefSeq (mRNA) NM_007264 NM_007412 RefSeq (protein) NP_009195 NP_031438 Location (UCSC) Chr 12: 56.99 – 57 Mb Chr 10: 127.58 – 127.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. ^[5]

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor. ^[6] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). ^[7]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000166856 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000058396 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
6. Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID   9367907.
7. Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID   9535752.
8. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID   9620797. S2CID   4364526.

Further reading

• Lah JJ, Frishman WH (2002). "Adrenomedullin: a vasoactive and natriuretic peptide with therapeutic potential". Heart Disease (Hagerstown, Md.). 2 (3): 259–65. PMID   11728267.
• Mukoyama M, Sugawara A, Nagae T, et al. (2002). "Role of adrenomedullin and its receptor system in renal pathophysiology". Peptides. 22 (11): 1925–1931. doi:10.1016/S0196-9781(01)00525-3. PMID   11754983. S2CID   3137509.
• Fowler DE, Wang P (2002). "The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review)". Int. J. Mol. Med. 9 (5): 443–9. doi:10.3892/ijmm.9.5.443. PMID   11956648.
• Kato J, Kitamura K, Kangawa K, Eto T (1995). "Receptors for adrenomedullin in human vascular endothelial cells". Eur. J. Pharmacol. 289 (2): 383–385. doi:10.1016/0922-4106(95)90117-5. PMID   7621913.
• Martínez A, Miller MJ, Catt KJ, Cuttitta F (1997). "Adrenomedullin receptor expression in human lung and in pulmonary tumors". J. Histochem. Cytochem. 45 (2): 159–64. doi: 10.1177/002215549704500202 . PMID   9016306.
• Hänze J, Dittrich K, Dötsch J, Rascher W (1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID   9367907.
• Martínez A, Elsasser TH, Muro-Cacho C, et al. (1997). "Expression of adrenomedullin and its receptor in normal and malignant human skin: a potential pluripotent role in the integument". Endocrinology. 138 (12): 5597–5604. doi: 10.1210/endo.138.12.5622 . PMID   9389548.
• Kennedy SP, Sun D, Oleynek JJ, et al. (1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID   9535752.
• Jiménez N, Calvo A, Martínez A, et al. (1999). "Expression of adrenomedullin and proadrenomedullin N-terminal 20 peptide in human and rat prostate". J. Histochem. Cytochem. 47 (9): 1167–78. doi: 10.1177/002215549904700909 . hdl: 10171/20168 . PMID   10449538.
• Kuwasako K, Kitamura K, Ito K, et al. (2002). "The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors". J. Biol. Chem. 276 (52): 49459–49465. doi: 10.1074/jbc.M108369200 . PMID   11591721.
• Forneris M, Gottardo L, Albertin G, et al. (2002). "Expression and function of adrenomedullin and its receptors in Conn's adenoma cells". Int. J. Mol. Med. 8 (6): 675–9. doi:10.3892/ijmm.8.6.675. PMID   11712085.
• Hänze J, Groneberg DA, Rose F, et al. (2002). "Genomic organization and regulation of a human 7-helix transmembrane receptor which is expressed in pulmonary epithelial cells and induced in hypoxia". Biochem. Biophys. Res. Commun. 291 (5): 1160–1165. doi:10.1006/bbrc.2002.6595. PMID   11883938.
• Dumont CE, Muff R, Flühmann B, et al. (2003). "Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats". Brain Res. 955 (1–2): 64–71. doi:10.1016/S0006-8993(02)03365-6. PMID   12419522. S2CID   33819362.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chosa E, Hamada H, Kitamura K, et al. (2003). "Expression of adrenomedullin and its receptor by chondrocyte phenotype cells". Biochem. Biophys. Res. Commun. 303 (1): 379–386. doi:10.1016/S0006-291X(03)00347-4. PMID   12646214.
• Xu P, Dai AG, Zhou HD, et al. (2004). "[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease]". Zhonghua Jie He He Hu Xi Za Zhi. 26 (12): 765–8. PMID   14720432.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• "GPR182". IUPHAR GPCR Database. International Union of Pharmacology (IUPHAR). 2007-12-04. Archived from the original on 2008-06-07. Retrieved 2008-07-03.