GPR182

Last updated
GPR182
Identifiers
Aliases GPR182 , 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDs OMIM: 605307 MGI: 109545 HomoloGene: 5255 GeneCards: GPR182
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007264

NM_007412

RefSeq (protein)

NP_009195

NP_031438

Location (UCSC) Chr 12: 56.99 – 57 Mb Chr 10: 127.58 – 127.59 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor. [5]

Contents

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor. [6] However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). [7]

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor. [8]

Related Research Articles

<span class="mw-page-title-main">Pleiotrophin</span> Protein in humans

Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and retinoic acid induced heparin-binding protein.

<span class="mw-page-title-main">Adrenomedullin</span>

Adrenomedullin is a vasodilator peptide hormone of uncertain significance in human health and disease. It was initially isolated in 1993 from a pheochromocytoma, a tumor of the adrenal medulla: hence the name.

<span class="mw-page-title-main">RAMP2</span> Protein-coding gene in the species Homo sapiens

Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.

<span class="mw-page-title-main">RAMP3</span> Protein-coding gene in the species Homo sapiens

Receptor activity modifying protein 3, also known as RAMP3, is a human gene.

Bradykinin receptor B<sub>2</sub> Protein-coding gene in the species Homo sapiens

Bradykinin receptor B2 is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

<span class="mw-page-title-main">CALCRL</span> Mammalian protein found in Homo sapiens

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein; it is a receptor for calcitonin gene-related peptide.

<span class="mw-page-title-main">Alpha-1A adrenergic receptor</span> Protein-coding gene in the species Homo sapiens

The alpha-1A adrenergic receptor, also known as ADRA1A, formerly known also as the alpha-1C adrenergic receptor, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it. There is no longer a subtype α1C receptor. At one time, there was a subtype known as α1C, but it was found to be identical to the previously discovered α1A receptor subtype. To avoid confusion, the naming convention was continued with the letter D.

<span class="mw-page-title-main">GPR45</span> Protein-coding gene in humans

Probable G-protein coupled receptor 45 is a protein that in humans is encoded by the GPR45 gene.

<span class="mw-page-title-main">GPR63</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.

<span class="mw-page-title-main">GPR85</span> Protein-coding gene in the species Homo sapiens

Probable G-protein coupled receptor 85 is a protein that in humans is encoded by the GPR85 gene.

<span class="mw-page-title-main">HCLS1</span> Protein-coding gene in the species Homo sapiens

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.

<span class="mw-page-title-main">Interleukin 12 receptor, beta 2 subunit</span> Protein-coding gene in the species Homo sapiens

Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor. IL12RB2 is its human gene. IL12RB2 orthologs have been identified in all mammals for which complete genome data are available.

<span class="mw-page-title-main">60S ribosomal protein L6</span> Protein found in humans

60S ribosomal protein L6 is a protein that in humans is encoded by the RPL6 gene.

<span class="mw-page-title-main">PLK2</span> Protein-coding gene in the species Homo sapiens

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.

<span class="mw-page-title-main">ABCD2</span> Protein-coding gene in humans

ATP-binding cassette sub-family D member 2 is a membrane pump/transporter protein that in humans is encoded by the ABCD2 gene.

<span class="mw-page-title-main">VASH1</span> Protein-coding gene in the species Homo sapiens

Vasohibin-1 is a protein that in humans is encoded by the VASH1 gene.

<span class="mw-page-title-main">ZFP161</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 161 homolog is a protein that in humans is encoded by the ZBTB14 gene.

<span class="mw-page-title-main">PTPN23</span> Protein-coding gene in the species Homo sapiens

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.

<span class="mw-page-title-main">CRLF2</span> Protein-coding gene in humans

Cytokine receptor-like factor 2 is a protein that in humans is encoded by the CRLF2 gene. It forms a ternary signaling complex with TSLP and interleukin-7 receptor-α, capable of stimulating cell proliferation through activation of STAT3, STAT5 and JAK2 pathways and is implicated in the development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH), or with P2Y purinoceptor 8 gene (P2RY8) is associated with B-progenitor- and Down syndrome- acute lymphoblastic leukemia (ALL).

<span class="mw-page-title-main">CCDC80</span> Protein-coding gene in humans

Coiled-coil domain-containing protein 80 is a protein that in humans is encoded by the CCDC80 gene. Bioinformatics analysis suggests the CCDC80 protein is a peroxiredoxin.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000166856 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058396 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
  6. Hänze J, Dittrich K, Dötsch J, Rascher W (November 1997). "Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system". Biochem. Biophys. Res. Commun. 240 (1): 183–188. doi:10.1006/bbrc.1997.7631. PMID   9367907.
  7. Kennedy SP, Sun D, Oleynek JJ, Hoth CF, Kong J, Hill RJ (March 1998). "Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response". Biochem. Biophys. Res. Commun. 244 (3): 832–837. doi:10.1006/bbrc.1998.8349. PMID   9535752.
  8. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (May 1998). "RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor". Nature. 393 (6683): 333–339. Bibcode:1998Natur.393..333M. doi:10.1038/30666. PMID   9620797. S2CID   4364526.

Further reading