GPR151

GPR151
Identifiers
Aliases	GPR151 , GALR4, GALRL, GPCR, PGR7, G protein-coupled receptor 151, GPCR-2037
External IDs	OMIM: 618487; MGI: 2441887; HomoloGene: 18754; GeneCards: GPR151; OMA:GPR151 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q32 Start 146,513,144 bp [1] End 146,516,190 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 B3 Start 42,710,946 bp [2] End 42,712,717 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex C1 segment Brodmann area 9 superior frontal gyrus primary visual cortex ganglionic eminence anterior cingulate cortex substantia nigra right frontal lobe putamen Top expressed in habenula lumbar spinal ganglion epithelium of small intestine paraventricular nucleus of thalamus embryo blastocyst lateral habenular nucleus gastrula central medial nucleus jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 134391 240239 Ensembl ENSG00000173250 ENSMUSG00000042816 UniProt Q8TDV0 Q7TSN6 RefSeq (mRNA) NM_194251 NM_181543 RefSeq (protein) NP_919227 NP_853521 Location (UCSC) Chr 5: 146.51 – 146.52 Mb Chr 18: 42.71 – 42.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

G-protein coupled receptor 151 is a protein that in humans is encoded by the GPR151 gene. ^{[5] [6]} It is weakly activated by galanin, but its endogenous ligand remains unknown. Studies have suggested GPR151 may play a role in several clinically significant processes such as inflammation, pain perception and reward-seeking behavior as well as hepatic glucose production, but further research into its function has been limited so far by a lack of selective agonists and antagonists for this receptor, with most research to date using knockout mice. ^{[7] [8] [9] [10] [11]}

References

1. GRCh38: Ensembl release 89: ENSG00000173250 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042816 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, et al. (April 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–4908. Bibcode:2003PNAS..100.4903V. doi: 10.1073/pnas.0230374100 . PMC   153653 . PMID   12679517.
6. "Entrez Gene: GPR151 G protein-coupled receptor 151".
7. Holmes FE, Kerr N, Chen YJ, Vanderplank P, McArdle CA, Wynick D (January 2017). "Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain". Molecular and Cellular Neurosciences. 78: 35–40. doi:10.1016/j.mcn.2016.11.010. PMC   5235321 . PMID   27913310.
8. Allain F, Carter M, Dumas S, Darcq E, Kieffer BL (November 2022). "The mu opioid receptor and the orphan receptor GPR151 contribute to social reward in the habenula". Scientific Reports. 12 (1) 20234. Bibcode:2022NatSR..1220234A. doi:10.1038/s41598-022-24395-z. PMC   9691715 . PMID   36424418.
9. Bielczyk-Maczynska E, Zhao M, Zushin PH, Schnurr TM, Kim HJ, Li J, et al. (December 2022). "G protein-coupled receptor 151 regulates glucose metabolism and hepatic gluconeogenesis". Nature Communications. 13 (1) 7408. Bibcode:2022NatCo..13.7408B. doi:10.1038/s41467-022-35069-9. PMC   9715671 . PMID   36456565.
10. Dai W, Wen M, Kalso E, Palada V (July 2025). "Circadian disruption upon painful peripheral nerve injury in mice: Temporal effects on transcriptome in pain-regulating sensory tissues". Neurobiology of Disease. 211 106934. doi:10.1016/j.nbd.2025.106934. PMID   40324566.
11. DePasquale O, O'Brien C, Gordon B, Barker DJ (May 2025). "The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance". ACS Chemical Neuroscience. 16 (9): 1639–1646. doi:10.1021/acschemneuro.4c00780. PMC   12333004 . PMID   40295925.

Further reading

• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID   12044878. S2CID   7116392.
• Ignatov A, Hermans-Borgmeyer I, Schaller HC (June 2004). "Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors". Neuropharmacology. 46 (8): 1114–1120. doi:10.1016/j.neuropharm.2004.02.004. PMID   15111018. S2CID   30647258.