GPRC5C

GPRC5C
Identifiers
Aliases	GPRC5C , RAIG-3, RAIG3, G protein-coupled receptor class C group 5 member C
External IDs	OMIM: 605949 MGI: 1917605 HomoloGene: 11099 GeneCards: GPRC5C
Gene location (Human)
Chr.	Chromosome 17 (human)
End	74,451,653 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	114,763,443 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right lobe of thyroid gland; ; cerebellar hemisphere; ; left lobe of thyroid gland; ; body of pancreas; ; body of stomach; ; popliteal artery; ; gastrocnemius muscle; ; right coronary artery; ; kidney;
	Top expressed in
	proximal tubule; ; inner renal medulla; ; yolk sac; ; kidney; ; olfactory epithelium; ; cerebellar cortex; ; skeletal muscle tissue; ; secondary oocyte; ; triceps brachii muscle; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity ; signal transducer activity ; protein kinase activator activity ;
Cellular component	integral component of membrane ; vesicle ; receptor complex ; plasma membrane ; integral component of plasma membrane ; extracellular exosome ; cytoplasmic vesicle membrane ; membrane ; cytoplasmic vesicle ; intracellular membrane-bounded organelle ;
Biological process	G protein-coupled receptor signaling pathway ; signal transduction ; activation of protein kinase activity ;
	Sources:Amigo / QuickGO
Orthologs
	55890
	70355
	ENSG00000170412
	ENSMUSG00000051043
	Q9NQ84
	Q8K3J9
	NM_018653 ; NM_022036 ; NM_001366261 ; NM_001366262
	NM_001110337 ; NM_001110338 ; NM_147217
	NP_061123 ; NP_071319 ; NP_001353190 ; NP_001353191
	NP_001103807 ; NP_001103808 ; NP_671750
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

G-protein coupled receptor family C group 5 member C is a protein that in humans is encoded by the GPRC5C gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene.^[6]

Related Research Articles

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.

Probable G-protein coupled receptor 88 is a protein that in humans is encoded by the GPR88 gene.

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

G protein-coupled receptor 1, also known as GPR1, is a protein that in humans is encoded by the GPR1 gene.

Probable G-protein coupled receptor 19 is a protein that in humans is encoded by the GPR19 gene. GPR19 has been proposed as the receptor for the peptide hormone adropin.

Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.

Endothelin B receptor-like protein 2 is a protein that in humans is encoded by the GPR37L1 gene.

Lysophosphatidic acid receptor 6, also known as LPA₆, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA₆ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

C-C chemokine receptor type 11 is a protein that in humans is encoded by the CCRL1 gene.

Probable G-protein coupled receptor 110 is a protein that in humans is encoded by the GPR110 gene. This gene encodes a member of the adhesion-GPCR receptor family. Family members are characterized by an extended extracellular region with a variable number of N-terminal protein modules coupled to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

G-protein coupled receptor family C group 5 member B is a protein that in humans is encoded by the GPRC5B gene.

G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.

Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene. This gene and its encoded mRNA was first identified as a phorbol ester-induced gene, and named Phorbol Ester Induced Gen 1 (PEIG-1); two years later it was rediscovered as a retinoic acid-inducible gene, and named Retinoic Acid-Inducible Gene 1 (RAIG1). Its encoded protein was later named Retinoic acid-induced protein 3.

G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene. This protein functions as a receptor of L-α-amino acids, cations, osteocalcin, and steroids. It is a membrane androgen receptor.

60S ribosomal protein L7a is a protein that in humans is encoded by the RPL7A gene.

PRA1 family protein 3 is a protein that in humans is encoded by the ARL6IP5 gene.

Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene.

Receptor expression-enhancing protein 2 is a protein that in humans is encoded by the REEP2 gene.

Solute carrier family 2, facilitated glucose transporter member 6 is a protein that in humans is encoded by the SLC2A6 gene.

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170412 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051043 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (Nov 2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
1 2 "Entrez Gene: GPRC5C G protein-coupled receptor, family C, group 5, member C".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170412 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051043 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10945465-5] Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (Nov 2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.

[entrez-6] 1 2 "Entrez Gene: GPRC5C G protein-coupled receptor, family C, group 5, member C".

[1]

[2]

[3]

[4]

[5]

[6]

GPRC5C

Contents

Function

See also

Related Research Articles

References

Further reading