Prolactin-releasing peptide receptor

PRLHR
Identifiers
Aliases	PRLHR , GPR10, GR3, PrRPR, prolactin releasing hormone receptor
External IDs	OMIM: 600895; MGI: 2135956; HomoloGene: 3134; GeneCards: PRLHR; OMA:PRLHR - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q26.11 Start 118,589,997 bp [1] End 118,595,648 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 D3 Start 60,455,170 bp [2] End 60,456,742 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary islet of Langerhans hypothalamus substantia nigra prefrontal cortex body of uterus vagina myometrium smooth muscle tissue Top expressed in hypothalamus cerebellum cerebellar cortex striatum of neuraxis mesencephalon More reference expression data BioGPS n/a
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity protein binding signal transducer activity neuropeptide receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane cilium Biological process female pregnancy G protein-coupled receptor signaling pathway hormone metabolic process feeding behavior signal transduction neuropeptide signaling pathway chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2834 226278 Ensembl ENSG00000119973 ENSMUSG00000045052 UniProt P49683 Q6VMN6 RefSeq (mRNA) NM_004248 NM_201615 RefSeq (protein) NP_004239 NP_963909 Location (UCSC) Chr 10: 118.59 – 118.6 Mb Chr 19: 60.46 – 60.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The prolactin-releasing peptide receptor (PrRPR) also known as G-protein coupled receptor 10 (GPR10) is a protein that in humans is encoded by the PRLHR gene.

PrRPR is a G-protein coupled receptor ^[5] that binds the prolactin-releasing peptide (PRLH). ^[6]

Function

PrRPR is a 7-transmembrane domain receptor for prolactin-releasing peptide that is highly expressed in the anterior pituitary. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000119973 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045052 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Marchese A, Heiber M, Nguyen T, Heng HH, Saldivia VR, Cheng R, Murphy PM, Tsui LC, Shi X, Gregor P (1995). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID   8666380.
6. Hinuma S, Habata Y, Fujii R, Kawamata Y, Hosoya M, Fukusumi S, Kitada C, Masuo Y, Asano T, Matsumoto H, Sekiguchi M, Kurokawa T, Nishimura O, Onda H, Fujino M (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. Bibcode:1998Natur.393..272H. doi:10.1038/30515. PMID   9607765. S2CID   4306854.
7. "Entrez Gene: PRLHR prolactin releasing hormone receptor".

Further reading

• Hinuma S, Onda H, Fujino M (1999). "The quest for novel bioactive peptides utilizing orphan seven-transmembrane-domain receptors". J. Mol. Med. 77 (6): 495–504. doi:10.1007/s001090050403. PMID   10475064. S2CID   19633923.
• Marchese A, Heiber M, Nguyen T, et al. (1996). "Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors". Genomics. 29 (2): 335–44. doi:10.1006/geno.1995.9996. PMID   8666380.
• Hinuma S, Habata Y, Fujii R, et al. (1998). "A prolactin-releasing peptide in the brain". Nature. 393 (6682): 272–6. Bibcode:1998Natur.393..272H. doi:10.1038/30515. PMID   9607765. S2CID   4306854.
• Fujii R, Fukusumi S, Hosoya M, et al. (1999). "Tissue distribution of prolactin-releasing peptide (PrRP) and its receptor". Regul. Pept. 83 (1): 1–10. doi:10.1016/S0167-0115(99)00028-2. PMID   10498338. S2CID   45945978.
• Langmead CJ, Szekeres PG, Chambers JK, et al. (2000). "Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor". Br. J. Pharmacol. 131 (4): 683–8. doi:10.1038/sj.bjp.0703617. PMC   1572376 . PMID   11030716.
• Lin SH, Arai AC, Wang Z, et al. (2001). "The carboxyl terminus of the prolactin-releasing peptide receptor interacts with PDZ domain proteins involved in alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor clustering". Mol. Pharmacol. 60 (5): 916–23. doi:10.1124/mol.60.5.916. PMID   11641419.
• Ozawa A, Yamada M, Satoh T, et al. (2002). "Transcriptional regulation of the human PRL-releasing peptide (PrRP) receptor gene by a dopamine 2 Receptor agonist: cloning and characterization of the human PrRP receptor gene and its promoter region". Mol. Endocrinol. 16 (4): 785–98. doi: 10.1210/me.16.4.785 . PMID   11923475.
• Takahashi K, Totsune K, Murakami O, et al. (2003). "Expression of prolactin-releasing peptide and its receptor in the human adrenal glands and tumor tissues of adrenocortical tumors, pheochromocytomas and neuroblastomas". Peptides. 23 (6): 1135–40. doi:10.1016/S0196-9781(02)00046-3. PMID   12126742. S2CID   24182099.
• Kemp DM, Lin JC, Ubeda M, Habener JF (2002). "NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region". FEBS Lett. 531 (2): 193–8. doi:10.1016/S0014-5793(02)03502-0. PMID   12417311. S2CID   31889191.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bhattacharyya S, Luan J, Challis B, et al. (2003). "Association of polymorphisms in GPR10, the gene encoding the prolactin-releasing peptide receptor with blood pressure, but not obesity, in a U.K. Caucasian population". Diabetes. 52 (5): 1296–9. doi: 10.2337/diabetes.52.5.1296 . PMID   12716769.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ellacott KL, Donald EL, Clarkson P, et al. (2005). "Characterization of a naturally-occurring polymorphism in the UHR-1 gene encoding the putative rat prolactin-releasing peptide receptor". Peptides. 26 (4): 675–81. doi:10.1016/j.peptides.2004.11.020. PMID   15752583. S2CID   2717651.
• Lagerström MC, Fredriksson R, Bjarnadóttir TK, et al. (2005). "Origin of the prolactin-releasing hormone (PRLH) receptors: evidence of coevolution between PRLH and a redundant neuropeptide Y receptor during vertebrate evolution". Genomics. 85 (6): 688–703. doi:10.1016/j.ygeno.2005.02.007. PMID   15885496.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.

External links

• "Prolactin-Releasing Peptide Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.
• PRLHR+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.