CMKLR2

CMKLR2
Identifiers
Aliases	CMKLR2 , G protein-coupled receptor 1, chemerin chemokine-like receptor 2, GPR1
External IDs	OMIM: 600239; MGI: 2385324; HomoloGene: 21094; GeneCards: CMKLR2; OMA:CMKLR2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q33.3 Start 206,175,316 bp [1] End 206,218,047 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 C2 Start 63,221,850 bp [2] End 63,253,702 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta stromal cell of endometrium testicle mucosa of esophagus skin of leg right adrenal cortex ventricular zone left adrenal gland gallbladder left adrenal cortex Top expressed in primary oocyte secondary oocyte zygote placenta urethra female urethra decidua male urethra epithelium of urethra epithelium of male urethra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide binding signal transducer activity protein binding G protein-coupled receptor activity peptide binding Cellular component membrane integral component of membrane integral component of plasma membrane neuron projection plasma membrane intracellular membrane-bounded organelle nucleoplasm Biological process chemical synaptic transmission neuropeptide signaling pathway G protein-coupled receptor signaling pathway signal transduction G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2825 241070 Ensembl ENSG00000183671 ENSG00000283448 ENSMUSG00000046856 UniProt P46091 Q8K087 RefSeq (mRNA) NM_001098199 NM_001261452 NM_001261453 NM_001261454 NM_001261455 NM_005279 NM_001389445 NM_146250 NM_001357045 RefSeq (protein) NP_001091669 NP_001248381 NP_001248382 NP_001248383 NP_001248384 NP_005270 NP_666362 NP_001343974 Location (UCSC) Chr 2: 206.18 – 206.22 Mb Chr 1: 63.22 – 63.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chemerin-like receptor 2, is a protein that in humans is encoded by the CMKLR2 gene. ^{[5] [6]}

CMKLR2 is a rhodopsin-like receptor and therefore a member of the G protein-coupled receptor family of transmembrane receptors. It functions as a receptor for chemerin. ^[7] Other receptors for chemerin include CMKLR1 and CCRL2.

References

1. ENSG00000283448 GRCh38: Ensembl release 89: ENSG00000183671, ENSG00000283448 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046856 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "CMKLR2 chemerin chemokine-like receptor 2 [ Homo sapiens (human) ]".
6. Marchese A, Docherty JM, Nguyen T, Heiber M, Cheng R, Heng HH, Tsui LC, Shi X, George SR, O'Dowd BF (October 1994). "Cloning of human genes encoding novel G protein-coupled receptors". Genomics. 23 (3): 609–18. doi:10.1006/geno.1994.1549. PMID   7851889.
7. Barnea G, Strapps W, Herrada G, Berman Y, Ong J, Kloss B, Axel R, Lee KJ (January 2008). "The genetic design of signaling cascades to record receptor activation". Proc. Natl. Acad. Sci. U.S.A. 105 (1): 64–9. doi: 10.1073/pnas.0710487105 . PMC   2224232 . PMID   18165312.

Further reading

• Shimizu N, Soda Y, Kanbe K, et al. (1999). "An Orphan G Protein-Coupled Receptor, GPR1, Acts as a Coreceptor To Allow Replication of Human Immunodeficiency Virus Types 1 and 2 in Brain-Derived Cells". J. Virol. 73 (6): 5231–9. doi:10.1128/JVI.73.6.5231-5239.1999. PMC   112576 . PMID   10233994.
• Tokizawa S, Shimizu N, Hui-Yu L, et al. (2000). "Infection of mesangial cells with HIV and SIV: identification of GPR1 as a coreceptor". Kidney Int. 58 (2): 607–17. doi: 10.1046/j.1523-1755.2000.00207.x . PMID   10916084.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kang MK, Kameta A, Shin KH, et al. (2003). "Senescence-associated genes in normal human oral keratinocytes". Exp. Cell Res. 287 (2): 272–81. doi:10.1016/S0014-4827(03)00061-2. PMID   12837283.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Jinno-Oue A, Shimizu N, Soda Y, et al. (2005). "The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1". J. Biol. Chem. 280 (35): 30924–34. doi: 10.1074/jbc.M500195200 . PMID   15919664.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.