P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene. [5] [6]
P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene. [5] [6]
The product of this gene, P2Y6, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene. [6]
Uridine-5′-triphosphate (UTP) is a pyrimidine nucleoside triphosphate, consisting of the organic base uracil linked to the 1′ carbon of the ribose sugar, and esterified with tri-phosphoric acid at the 5′ position. Its main role is as substrate for the synthesis of RNA during transcription. UTP is the precursor for the production of CTP via CTP synthetase. UTP can be biosynthesized from UDP by Nucleoside Diphosphate Kinase after using the phosphate group from ATP. UDP + ATP ⇌ UTP + ADP; both UTP and ATP are energetically equal.
P2Y receptors are a family of purinergic G protein-coupled receptors, stimulated by nucleotides such as adenosine triphosphate, adenosine diphosphate, uridine triphosphate, uridine diphosphate and UDP-glucose.To date, 8 P2Y receptors have been cloned in humans: P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14.
Leukotriene B4 receptor 1 is a protein that in humans is encoded by the LTB4R gene.
RAR-related orphan receptor alpha (RORα), also known as NR1F1 is a nuclear receptor that in humans is encoded by the RORA gene. RORα participates in the transcriptional regulation of some genes involved in circadian rhythm. In mice, RORα is essential for development of cerebellum through direct regulation of genes expressed in Purkinje cells. It also plays an essential role in the development of type 2 innate lymphoid cells (ILC2) and mutant animals are ILC2 deficient. In addition, although present in normal numbers, the ILC3 and Th17 cells from RORα deficient mice are defective for cytokine production.
Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.
P2Y purinoceptor 1 is a protein that in humans is encoded by the P2RY1 gene.
P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.
Angiotensin II receptor type 2, also known as the AT2 receptor is a protein that in humans is encoded by the AGTR2 gene.
Melanocortin 5 receptor (MC5R) is a protein that in humans is encoded by the MC5R gene. It is located on the chromosome 18 in the human genome. When the MC5R was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.
P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.
Somatostatin receptor type 1 is a protein that in humans is encoded by the SSTR1 gene.
Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.
P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.
Lysophosphatidic acid receptor 6, also known as LPA6, P2RY5 and GPR87, is a protein that in humans is encoded by the LPAR6 gene. LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).
Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.
P2Y purinoceptor 13 is a protein that in humans is encoded by the P2RY13 gene.
P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.
P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.
BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.
Forkhead box protein A1 (FOXA1), also known as hepatocyte nuclear factor 3-alpha (HNF-3A), is a protein that in humans is encoded by the FOXA1 gene.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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