MRS-1706

Last updated
MRS-1706
MRS-1706.svg
Names
IUPAC name
N-(4-Acetylphenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]acetamide
Other names
MRS 1706
Identifiers
3D model (JSmol)
ChemSpider
MeSH C496145
PubChem CID
UNII
  • InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30) X mark.svgN
    Key: ZKUCFFYOQOJLGT-UHFFFAOYSA-N X mark.svgN
  • InChI=1/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
    Key: ZKUCFFYOQOJLGT-UHFFFAOYAX
  • CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C3=CC=C(C=C3)OCC(=O)NC4=CC=C(C=C4)C(=O)C
Properties
C27H29N5O5
Molar mass 503.56
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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MRS-1706 is a selective inverse agonist for the adenosine A2B receptor. [1] It inhibits release of interleukins and has an antiinflammatory effect. [2] [3]

References

  1. ↑ Li Q, Ye K, Blad CC, den Dulk H, Brouwer J, Ijzerman AP, Beukers MW (February 2007). "ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor". The Journal of Pharmacology and Experimental Therapeutics. 320 (2): 637–45. doi:10.1124/jpet.106.111203. PMID   17077318.
  2. ↑ Vazquez JF, Clement HW, Sommer O, Schulz E, van Calker D (May 2008). "Local stimulation of the adenosine A2B receptors induces an increased release of IL-6 in mouse striatum: an in vivo microdialysis study". Journal of Neurochemistry. 105 (3): 904–9. doi: 10.1111/j.1471-4159.2007.05191.x . PMID   18088370.
  3. ↑ Ryzhov S, Zaynagetdinov R, Goldstein AE, Novitskiy SV, Dikov MM, Blackburn MR, et al. (June 2008). "Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells". Journal of Immunology. 180 (11): 7212–20. doi: 10.4049/jimmunol.180.11.7212 . PMC   3628765 . PMID   18490720.


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