DMPX

DMPX

Clinical data
ATC code	None
Identifiers
IUPAC name 3,7-Dimethyl-1-(2-propyn-1-yl)-3,7-dihydro-1H-purine-2,6-dione
CAS Number	14114-46-6  Y
PubChem CID	99562
ChemSpider	89948
UNII	5YFR5SPS6T
CompTox Dashboard (EPA)	DTXSID30161577
ECHA InfoCard	100.162.258
Chemical and physical data
Formula	C10H10N4O2
Molar mass	218.216 g·mol−1
3D model (JSmol)	Interactive image
SMILES Cn2cnc(c2c1=O)n(C)c(=O)n1CC#C
InChI InChI=1S/C10H10N4O2/c1-4-5-14-9(15)7-8(11-6-12(7)2)13(3)10(14)16/h1,6H,5H2,2-3H3 Key:IORPOFJLSIHJOG-UHFFFAOYSA-N

DMPX (3,7-dimethyl-1-propargylxanthine) is a caffeine analog which displays affinity for A₂ adenosine receptors, in contrast to the A₁ subtype receptors. ^[1] DMPX had 28 times and 15 times higher potency than caffeine in blocking, respectively, the peripheral and central effects of the adenosine agonist NECA. The locomotor stimulation caused by DMPX (ED₅₀ 10 μmol/kg) was similarly higher than caffeine. ^[1]

See also

• DPCPX
• 8-PT
• CPX (8-CPT)
• 8-Chlorotheophylline
• Theophylline

References

1. Seale TW, Abla KA, Shamim MT, Carney JM, Daly JW (1988). "3,7-Dimethyl-1-propargylxanthine: a potent and selective in vivo antagonist of adenosine analogs". Life Sciences. 43 (21): 1671–84. doi:10.1016/0024-3205(88)90478-x. PMID   3193854.