Etamivan

Last updated
Etamivan
Ethamivan.svg
Clinical data
Trade names Analepticon
ATC code
Identifiers
  • N,N-Diethyl-4-hydroxy-3-methoxybenzamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.005.599 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C12H17NO3
Molar mass 223.272 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)c1ccc(O)c(OC)c1
  • InChI=1S/C12H17NO3/c1-4-13(5-2)12(15)9-6-7-10(14)11(8-9)16-3/h6-8,14H,4-5H2,1-3H3 X mark.svgN
  • Key:BQJODPIMMWWMFC-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Etamivan (INN, or ethamivan (USAN); trade names Analepticon, Emivan, and Vandid) is a respiratory stimulant drug [1] related to nikethamide. It was mainly used in the treatment of barbiturate overdose [2] and chronic obstructive pulmonary disease, [3] but has now largely fallen into disuse.

Adverse effects which are common to the respiratory stimulant class include sneezing, coughing, and laryngospasm when infused too rapidly. More serious adverse events include muscle twitching, tremors, and convulsions. The dose to treat barbiturate intoxication or carbon dioxide narcosis in adults ranges from 0.5 mg/kg to 5.0 mg/kg, infused intravenously over several minutes. Epilepsy and the use of monoamine oxidase inhibitors or other adrenergic drugs are contraindications. [4]

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References

  1. Hirsh K, Wang SC (May 1975). "Respiratory stimulant effects of ethamivan and picrotoxin". The Journal of Pharmacology and Experimental Therapeutics. 193 (2): 657–63. PMID   1173598.
  2. Wheeldon PJ, Perry AW (July 1963). "The use of ethamivan in the treatment of barbiturate poisoning". Canadian Medical Association Journal. 89: 20–2. PMC   1921664 . PMID   14000228.
  3. Sproule BJ, Jans RL, Breitkreutz H, Mahon W (December 1964). "Effects of ethamivan in patients with chronic respiratory disease". Canadian Medical Association Journal. 91: 1203–8. PMC   1928498 . PMID   14226094.
  4. American Medical Association Dept of Drugs (1977). AMA Drug Evaluations (3rd ed.). Littleton, Mass.: Pub. Sciences Group. p. N-61. ISBN   978-0-88416-175-2. OCLC   1024170745.