Thozalinone

Last updated
Thozalinone
Thozalinone.svg
Thozalinone molecule spacefill.png
Clinical data
Other namesTozalinone, Thozalinon
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
Chemical and physical data
Formula C11H12N2O2
Molar mass 204.229 g·mol−1
3D model (JSmol)
Chirality Racemic mixture
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Thozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe. [1] [2] [3] [4] [5] It has also been trialed as an anorectic. [6] Thozalinone is described as a "dopaminergic stimulant", [7] and likely acts via inducing the release of dopamine and to a minimal extent norepinephrine; similar to analogue pemoline, it is seemingly devoid of abuse potential unlike common psychostimulants that increase catecholamines. [2] [7] [8]

See also

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References

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  2. 1 2 Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology. 7 (4): 566–78. doi:10.1016/0041-008X(65)90042-6. PMID   4378772.
  3. Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN   0-412-54090-8.
  4. Merck index on CD-ROM: Windows. London: Chapman & Hall EPD. 1998. ISBN   0-412-82910-X.
  5. Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB (December 1966). "A double-blind study of thozalinone (C1 39,808) in depressed outpatients". Current Therapeutic Research, Clinical and Experimental. 8 (12): 621–2. PMID   4962734.
  6. Leite AC, Liepen LL, Costa VP (September 1971). "[Clinical trial of Stimsem Thozalinone in the treatment of obese patients]". Revista Brasileira de Medicina (in Portuguese). 28 (9): 475–8. PMID   5139648.
  7. 1 2 Yen-Koo HC, Balazs T (1980). "Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice". Drug and Chemical Toxicology. 3 (2): 237–47. doi:10.3109/01480548009108286. PMID   6112126.
  8. Yen-Koo HC, Davis DA, Balazs T (1985). "Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice". Drug and Chemical Toxicology. 8 (6): 495–502. doi:10.3109/01480548509041072. PMID   2868876.