Bromantane

Last updated

Bromantane
Bromantane structure.svg
Bromantane ball-and-stick model.png
Clinical data
Trade names Ladasten
Other namesBromantan; Bromontan; ADK-709; N-(2-Adamantyl)-4-bromoaniline; N-(2-Adamantyl)-N-(4-Bromophenyl)amine; N-(4-Bromophenyl)-2-adamantanamine
Routes of
administration 		By mouth
ATC code
  • None
Legal status
Legal status
  • US:Unscheduled,not FDA approved
  • Rx-only (RU)
Pharmacokinetic data
Bioavailability 27.5%[ citation needed ]
Onset of action 1.5–2 hours (PO)
Elimination half-life 11.21 hours (in humans), [1]
7 hours (in rats) [2]
Duration of action 8–12 hours (PO)
Identifiers
  • N-(4-Bromophenyl)adamantan-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.213.907 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C16H20BrN
Molar mass 306.247 g·mol−1
3D model (JSmol)
  • C1C2CC3CC1CC(C2)C3NC4=CC=C(C=C4)Br
  • InChI=1S/C16H20BrN/c17-14-1-3-15(4-2-14)18-16-12-6-10-5-11(8-12)9-13(16)7-10/h1-4,10-13,16,18H,5-9H2 X mark.svgN
  • Key:LWJALJDRFBXHKX-UHFFFAOYSA-N X mark.svgN
   (verify)

Bromantane, sold under the brand name Ladasten, is an atypical central nervous system (CNS) stimulant and anxiolytic drug of the adamantane family that is related to amantadine and memantine. Medically, it is approved in Russia for the treatment of neurasthenia. Although the effects of bromantane have been determined to be dependent on the dopaminergic and possibly serotonergic neurotransmitter systems, its exact mechanism of action is unknown, [3] [4] and is distinct in its properties relative to typical stimulants such as amphetamine. Bromantane has sometimes been described as an actoprotector (synthetic adaptogen). [5] [6]

Contents

Effects

Clinical research

The therapeutic effects of bromantane in asthenia are said to onset within 1–3 days. [7] It has been proposed that the combination of stimulant and anxiolytic activity may give bromantane special efficacy in the treatment of asthenia. [8]

In a large-scale, multi-center clinical trial of 728 patients diagnosed with asthenia in Russia, bromantane was given for 28 days at a daily dose of 50 mg or 100 mg. [7] The study concluded with an impression score of 76.0% on the CGI-S and 90.8% on the CGI-I for bromantane, indicating that it is broadly applicable and highly effective. [7] The therapeutic benefit against asthenia was observed to still be present one month after discontinuation of the drug. [7] 3% of patients experienced side effects; though none were considered serious; and 0.8% of patients discontinued treatment due to side effects. [7] Bromantane was also noted to normalize the sleep-wake cycle. [7]

Psychotropic effects

Bromantane is described primarily as a mild stimulant [9] and anxiolytic. [8] It is also said to possess anti-asthenic properties. [10] [8] Bromantane is reported to improve physical and mental performance, hence it could be considered a performance-enhancing drug. [10]

Bromantane has been found to lower the levels of pro-inflammatory cytokines IL-6, IL-17 and IL-4 and to normalize behavior in animal models of depression, and may possess clinical efficacy as an antidepressant. [11] [12] [13] It has also been found to increase sexual receptivity and proceptivity in rats of both sexes, which was attributed to its dopaminergic actions. [14] It has been proposed that bromantane may suppress prolactin levels by virtue of its dopaminergic properties as well. [15] Bromantane has been found to "agonize" amphetamine-induced stereotypies in vivo, suggesting that it might potentiate certain effects of other stimulants. [4]

The stimulant effects of bromantane onset gradually within 1.5–2 hours and last for 8–12 hours when taken orally. [9]

Pharmacology

Pharmacodynamics

Dopamine synthesis enhancement

Although it is frequently labeled as a stimulant, bromantane is distinct in its pharmacology and effects relative to typical stimulants, such as the phenethylamines (e.g., amphetamine and its derivatives) and their structural analogues (e.g., methylphenidate, cocaine, mesocarb, etc.). [16] [17] Whereas the latter directly act on the dopamine transporter (DAT) to inhibit the reuptake and/or induce the release of dopamine, bromantane instead acts via indirect genomic mechanisms to produce a rapid, pronounced, and long-lasting upregulation in a variety of brain regions of the expression of tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AAAD) (also known as DOPA decarboxylase), key enzymes in the dopamine biosynthesis pathway. [9] [18] [19] For instance, a single dose of bromantane produces a 2–2.5 fold increase in TH expression in the rat hypothalamus 1.5–2 hours post-administration. [20] The biosynthesis and release of dopamine subsequently increase in close correlation with TH and AAAD upregulation. [9] [18] [19] Enhancement of dopaminergic neurotransmission is observed in the hypothalamus, striatum, ventral tegmental area, nucleus accumbens, and other regions. [9] [18] [19] As such, the key mechanism of the pharmacological activity and psychostimulant effects of bromantane is activation of the de novo synthesis of dopamine via modulation of gene expression. [18]

A selection of quoted excerpts from the medical literature detail the differences between bromantane and typical stimulants: [10] [9] [16]

  • "Bromantane [does] not concede well-known psychostimulant of phenylalkylamine structure and its analogs (amphetamine, [mesocarb], [methylphenidate], etc.) by specific activity. In contrast, bromantane has neither addictive potential nor reveals redundant and exhausting activation of sympaticoadrenergic system, or decelerates the restoring of work capacity at preventive application before forthcoming activity in complicated conditions (hypoxia, high environmental temperature, physical overfatigue, emotional stress, etc.). Bromantane has no prohypoxic activity."
  • "The use of the drug, in contrast to the action of a typical psychostimulant, is not associated with the phenomenon of hyperstimulation and causes no consequences such as functional exhaustion of the body."
  • "Bromantane administration in therapeutic doses is characterized by the almost full absence of side effects including manifestations of withdrawal syndrome and hyperstimulation."
  • "[Bromantane] has low peripheral sympathomimetic effects. Moreover, no signs of [bromantane] dependence and withdrawal symptoms were found."

Bromantane is well tolerated and elicits few side effects (including peripheral sympathomimetic effects and hyperstimulation), does not appear to produce tolerance or dependence, has not been associated with withdrawal symptoms upon discontinuation, and displays an absence of addiction potential, contrary to typical stimulants. [10] [8] In accordance with human findings, animals exposed to bromantane for extended periods of time do not appear to develop tolerance or dependence. [21]

The precise direct molecular mechanism of action by which bromantane ultimately acts as a dopamine synthesis enhancer is unknown. [3] [4] However, it has been determined that activation of certain cAMP-, Ca2+-, and phospholipid-dependent protein kinases such as protein kinase A and especially protein kinase C corresponds with the manifestation of the pharmacological effects of bromantane. [17] [22] Bromantane may activate intracellular signaling cascades by some mechanism (e.g., agonizing some as-yet-undetermined receptor) to in turn activate protein kinases, which in turn cause increased transcription of TH and AAAD. [17] [22]

The related drugs amantadine and memantine also have many properties similar to those of bromantane. [23] [24] [25]

Researchers discovered that amantadine and memantine bind to and act as agonists of the σ1 receptor (Ki = 7.44 μM and 2.60 μM, respectively) and that activation of the σ1 receptor is involved in the central dopaminergic effects of amantadine at therapeutically relevant concentrations; the authors of the study stated that this could also be the mechanism of action of bromantane, as it is in the same family of structurally related compounds and evidence suggests a role of dopamine in its effects. But this could also be seen as evidence of the contrary since bromantane has effects that are distinctly different from amantadine and memantine.

Monoamine reuptake inhibition

Bromantane was once thought to act as a reuptake inhibitor of serotonin and dopamine. [3] [16] [26] While bromantane can inhibit the reuptake of serotonin, dopamine, and to a lesser extent norepinephrine in vitro in rat brain tissue, the concentrations required to do so are extremely high (50–500 μM) and likely not clinically relevant. [16] [26] Although one study found an IC50 for dopamine transport of 3.56 μM, relative to 28.66 nM for mesocarb; neither drug affected serotonin transport at the tested concentrations, in contrast. [27] The lack of typical stimulant-like effects and adverse effects seen with bromantane may help corroborate the notion that it is not acting significantly as a monoamine reuptake inhibitor, but rather via a different mechanism.

Other actions

Bromantane has been found to increase the expression of neurotrophins including brain-derived neurotrophic factor and nerve growth factor in certain rat brain areas. [28]

Although not relevant at clinical dosages, bromantane has been found to produce anticholinergic effects, including both antimuscarinic and antinicotinic actions, at very high doses in animals, and these effects are responsible for its toxicity (that is, LD50) in animals. [26] [29] [30] [31]

Pharmacokinetics

Bromantane is used clinically in doses of 50 mg to 100 mg per day in the treatment of asthenia. [7]

The main metabolite of bromantane is 6β-hydroxybromantane. [32]

Chemistry

Bromantane is an adamantane derivative. It is also known as adamantylbromphenylamine, from which its name was derived. [1]

Closely related adamantanes with similar effects include adapromine, amantadine, chlodantane, gludantane (gludantan), memantine, and rimantadine. [23]

Synthesis

Patents: 57%: Bromantane synthesis.svg
Patents: 57%:

The reductive amination between Adamantanone [700-58-3] and 4-Bromoaniline [106-40-1] in the presence of formic acid gave bromantane (3).

History

In the 1960s, the adamantane derivative amantadine (1-aminoadamantane) was developed as an antiviral drug for the treatment of influenza. [36] Other adamantane antivirals subsequently followed, such as rimantadine (1-(1-aminoethyl)adamantane) and adapromine (1-(1-aminopropyl)adamantane). [5] [36] It was serendipitously discovered in 1969 that amantadine possesses central dopaminergic stimulant-like properties, [37] [38] and subsequent investigation revealed that rimantadine and adapromine also possess such properties. [39] Amantadine was then developed and introduced for the treatment of Parkinson's disease due to its ability to increase dopamine levels in the brain. [37] It has also notably since been used to help alleviate fatigue in multiple sclerosis. [40]

With the knowledge of the dopaminergic stimulant effects of the adamantane derivatives, bromantane, which is 2-(4-bromophenylamino) adamantane, was developed in the 1980s at the Zakusov State Institute of Pharmacology, USSR Academy of Medical Sciences (now the Russian Academy of Medical Sciences) in Moscow as "a drug having psychoactivating and adaptogen properties under complicated conditions (hypoxia, high environmental temperature, physical overfatigue, emotional stress, etc.)". [10] [4] It was found to produce more marked and prolonged stimulant effects than the other adamantanes, [41] and eventually entered use. [10] The drug was notably given to soldiers in the Soviet and Russian militaries to "shorten recovery times after strong physical exertion". [10] After the break-up of the Soviet Union in 1991, bromantane continued to be researched and characterized but was mainly limited in use to sports medicine (for instance, to enhance athletic performance). [10] In 1996, it was encountered as a doping agent in the 1996 Summer Olympics when several Russian athletes tested positive for it, and was subsequently placed on the World Anti-Doping Agency banned list in 1997 as a stimulant and masking agent. [10] [42]

Bromantane was eventually repurposed in 2005 as a treatment for neurasthenia. [43] It demonstrated effectiveness and safety for the treatment of the condition in extensive, large-scale clinical trials, [7] and was approved for this indication in Russia under the brand name Ladasten sometime around 2009. [8]

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References

  1. 1 2 "Ladasten (adamantylbromphenylamine) Tablets for Oral Use. Full Prescribing Information". Russian State Register of Medicines (in Russian). Lekko CJSC. p. 1. Archived from the original on 3 February 2016. Retrieved 27 January 2016.
  2. ↑ Neild PJ, Gazzard BG (September 1997). "HIV-1 infection in China". Lancet. 350 (9082): 963. doi: 10.1016/S0140-6736(05)63309-0 . PMID   9314899. S2CID   40317188.
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  4. 1 2 3 4 Iezhitsa IN, Spasov AA, Bugaeva LI (2001). "Effects of bromantan on offspring maturation and development of reflexes". Neurotoxicology and Teratology. 23 (2): 213–222. doi:10.1016/S0892-0362(01)00119-2. PMID   11348840.
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  6. ↑ Morozov IS, Ivanova IA, Lukicheva TA (2001). "Actoprotector and Adaptogen Properties of Adamantane Derivatives (A Review)". Pharmaceutical Chemistry Journal. 35 (5): 235–238. doi:10.1023/A:1011905302667. ISSN   0091-150X. S2CID   29475883.
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  17. 1 2 3 Vakhitova YV, Yamidanov RS, Vakhitov VA, Seredenin SB (2005). "cDNA macroarray analysis of gene expression changes in rat brain after a single administration of a 2-aminoadamantane derivative". Molecular Biology. 39 (2): 244–252. doi:10.1007/s11008-005-0035-7. ISSN   0026-8933. S2CID   39459723.
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  19. 1 2 3 Vakhitova YV, Yamidanov RS, Vakhitov VA, Seredenin SB (2005). "The effect of ladasten on gene expression in the rat brain". Doklady. Biochemistry and Biophysics. 401 (1–6): 150–153. doi:10.1007/s10628-005-0057-z. PMID   15999825. S2CID   28048257.
  20. ↑ Vakhitova I, Sadovnikov SV, Iamidanov RS, Seredenin SB (July 2006). "[Cytosine demethylation in the tyrosine hydroxylase gene promoter in the hypothalamus cells of the rat brain under the action of an aminoadamantane derivative Ladasten]". Genetika (in Russian). 42 (7): 968–975. PMID   16915929.
  21. ↑ Iëzhitsa IN, Bugaeva LI, Spasov AA, Morozov IS (2000). "[Effect of bromantane on the rat neurologic status in two month course]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 63 (5): 13–17. PMID   11109517.
  22. 1 2 Vakhitova I, Salimgareeva MK, Seredenin SB (2004). "[Effect of ladasten on the proteinase C activity in the rat brain cells]". Eksperimental'naia i Klinicheskaia Farmakologiia (in Russian). 67 (2): 12–15. PMID   15188752.
  23. 1 2 Morozov IS, Ivanova IA, Lukicheva TA (2001). "[Actoprotector and adaptogen properties of adamantane derivatives (a review)". Pharmaceutical Chemistry Journal. 35 (5): 235–238. doi:10.1023/A:1011905302667.
  24. ↑ Danysz W, Dekundy A, Scheschonka A, Riederer P (February 2021). "Amantadine: reappraisal of the timeless diamond-target updates and novel therapeutic potentials". J Neural Transm (Vienna). 128 (2): 127–169. doi:10.1007/s00702-021-02306-2. PMC   7901515 . PMID   33624170.
  25. ↑ Huber TJ, Dietrich DE, Emrich HM (March 1999). "Possible use of amantadine in depression". Pharmacopsychiatry. 32 (2): 47–55. doi:10.1055/s-2007-979191. PMID   10333162.
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