O-2172

O-2172

Identifiers
IUPAC name methyl 2-cyclopentyl-2-(3,4-dichlorophenyl)acetate
CAS Number	521062-92-0  Y
PubChem CID	11778793
ChemSpider	9953475  N
UNII	SPK6RB6JMK
CompTox Dashboard (EPA)	DTXSID901027195
Chemical and physical data
Formula	C14H16Cl2O2
Molar mass	287.18 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1Cl)C(C(=O)OC)C2CCCC2
InChI InChI=1S/C14H16Cl2O2/c1-18-14(17)13(9-4-2-3-5-9)10-6-7-11(15)12(16)8-10/h6-9,13H,2-5H2,1H3 N Key:NEHPFNBRZYFWFN-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

O-2172 is a drug developed by Organix Inc, which acts as a stimulant and potent dopamine reuptake inhibitor. It is an analogue of methylphenidate where the phenyl ring has had a 3,4-dichloro substitution added, and the piperidine ring has been replaced by cyclopentane. It is around 1/3 the potency of methylphenidate, demonstrating that even with the important binding group of the nitrogen lone pair removed entirely, selective DAT binding and reuptake inhibition is still possible. ^{[1] [2]}

It has been sold as a designer drug under the name DCCPM. ^[3]

See also

• Tropoxane
• O-4210
• 3,4-Dichloromethylphenidate

References

1. Meltzer PC, Wang P, Blundell P, Madras BK (April 2003). "Synthesis and evaluation of dopamine and serotonin transporter inhibition by oxacyclic and carbacyclic analogues of methylphenidate". Journal of Medicinal Chemistry. 46 (8): 1538–1545. doi:10.1021/jm0205292. PMID   12672255.
2. Runyon SP, Carroll FI (2006). "Dopamine transporter ligands: recent developments and therapeutic potential". Current Topics in Medicinal Chemistry. 6 (17): 1825–1843. doi:10.2174/156802606778249775. PMID   17017960.
3. Yurchenko R, Galetskaya I, Piatsetskaya A (August 2024). "462 O-2172 (DCCPM)". Psychoactive products market observation Annual review. Trend analysis. (56). AIPSIN. doi:10.13140/RG.2.2.21830.28480 . Retrieved September 8, 2025.