Meclofenoxate

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Meclofenoxate
Meclofenoxate.svg
Clinical data
AHFS/Drugs.com International Drug Names
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances) [1]
  • US:Not FDA approved
  • In general: ℞ (Prescription only)
Identifiers
  • 2-Dimethylaminoethyl (4-chlorophenoxy)acetate
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.107 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C12H16ClNO3
Molar mass 257.71 g·mol−1
3D model (JSmol)
  • Clc1ccc(cc1)OCC(=O)OCCN(C)C
  • InChI=1S/C12H16ClNO3/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11/h3-6H,7-9H2,1-2H3 X mark.svgN
  • Key:XZTYGFHCIAKPGJ-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement. [2] [3] [4] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

Contents

In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests. [5] Meclofenoxate also increases cellular membrane phospholipids.[ citation needed ] It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.

Side effects

Meclofenoxate is considered to be safe and high in tolerability. However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.

Research

Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%. [6] [7]

Brand names

In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl. [8] In the US, meclofenoxate is sold as a dietary supplement, although it is an unapproved drug. [4]

See also

References

  1. ↑ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN   978-1-4757-2085-3.
  3. ↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN   978-3-88763-075-1.
  4. 1 2 Cohen PA, Avula B, Khan I (October 2022). "The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements". Clinical Toxicology. 60 (10): 1156–1158. doi:10.1080/15563650.2022.2109485. PMID   35959800. S2CID   251516603.
  5. ↑ Marcer D, Hopkins SM (May 1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and Ageing. 6 (2): 123–31. doi: 10.1093/ageing/6.2.123 . PMID   329662.
  6. ↑ Donaldson T (1 January 2003). "A Brief History of Anti-aging Drugs". In Klatz R, Goldman B (eds.). The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. pp. 66–. ISBN   978-0-9668937-3-1.
  7. ↑ Hothschild R (August 1973). "Effect of dimethylamnioethyl p-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice". Experimental Gerontology. 8 (4): 177–183. doi:10.1016/0531-5565(73)90024-7. PMID   4147092.
  8. ↑ Zhou Y (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN   978-1-4831-9193-5.
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